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    Identification of Potential Anticancer Protein Targets in Cytotoxicity Mediated by Tropical Medicinal Fern Extracts

    Siok‑Thing Tan2, Hean‑Chooi Ong3, Tsun‑Thai Chai2,4, Fai‑Chu Wong2,4★★ Corresponding author

    1. 1Centre for Biodiversity Research, Universiti Tunku Abdul Rahman, Malaysia.
    2. 2Biochemistry Program, Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia.
    3. 3Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

    CORRESPONDENCE

    Fai‑Chu Wong

    Biochemistry Program, Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia.

    wongfc@utar.edu.my

    Received: 29-06-2017; Revised: 16-08-2017.

    Volume 14, Issue 54 · pp. 227–230 · PUBLISHED 10 April 2018 · DOI: 10.4103/pm.pm_282_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Medicinal fern species represent a potentially important source for both food and medicinal applications. Previously, two underutilized tropical fern species (Blechnum orientale and Phymatopteris triloba) were reported with cytotoxic activities against selected cancer cell lines. However, the exact mechanism remains elusive. Objective: In this paper, we reported the identification of six differentially expressed proteins isolated from cancer cells, following exposure to the cytotoxic fern extracts. Materials and Methods: The identities of these cancer proteins were determined by matrix‑assisted laser desorption ionization time‑of‑flight protein sequencing. Results: The cancer proteins were identified as follows: elongation factor 1‑γ, glyceraldehydes‑3‑phosphate dehydrogenase, heat shock protein 90‑β, heterogeneous nuclear ribonucleoprotein‑A2/B1, truncated nucleolar phosphoprotein B23, and tubulin‑β chain. To the best of our knowledge, this paper represents the first time these cancer proteins are being reported, following exposure to the aforementioned cytotoxic fern extracts. Conclusion: It is hoped that further efforts in this direction could lead to the identification and development of target‑specific chemotherapeutic agents.

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      Tan, S., Ong, H., Chai, T., & Wong, F. (2018). Identification of Potential Anticancer Protein Targets in Cytotoxicity Mediated by Tropical Medicinal Fern Extracts. Pharmacognosy Magazine, 14(54), 227–230. https://doi.org/10.4103/pm.pm_282_17