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    Article

    Optimal Processing Conditions of Boswellia carteri Birdw. Using Response Surface Methodology

    Jee–Hyun Yoon1★, Jung–Hoon Kim1★, Seong–Sik Ham1, Bu–Yeon Gang1, Seung–Ho Lee3, Goya Choi4, Young–Sik Kim5, Guemsan Lee6, Young–Sung Ju1★★ Corresponding author

    1. 1Department of Herbology, College of Korean Medicine, Woosuk University, Jeonju‑si, Jeollabuk‑do 54986.
    2. 2Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan‑si, Gyeongsangnam‑do 50612.
    3. 3Mibyeong Research Center, Korea Institute of Oriental Medicine.
    4. 4K–Herb Research Center, Korea Institute of Oriental Medicine, Yuseong‑gu, Daejeon 34054.
    5. 5Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Dongdaemun‑gu, Seoul 02447.
    6. 6Department of Herbology, College of Korean Medicine, Wonkwang University, Iksan‑si, Jeollabuk‑do 54538, Republic of Korea.

    CORRESPONDENCE

    Jee–Hyun Yoon

    Department of Herbology, College of Korean Medicine, Woosuk University, Jeonju‑si, Jeollabuk‑do 54986.

    jys9875@woosuk.ac.kr

    Received: 11-04-2017; Revised: 25-04-2017.

    Volume 14, Issue 54 · pp. 235–241 · PUBLISHED 10 April 2018 · DOI: 10.4103/pm.pm_140_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Boswellia carteri Bridw. is being widely used for its anti‑inflammatory properties, as well as for wound healing, antimicrobial, and immunomodulatory properties, and boswellic acids (BAs) are considered to be the main active constituents. Objectives: To investigate optimal conditions of stir‑baking process for the resin of B. carteri with vinegar of using response surface methodology (RSM). Materials and Methods: The concentration of acetic acid, heating temperature, and heating time were set as influential factors, and the yields of chemical compounds were the response values which were optimally designed by a Box–Behnken design. The amounts of 11-keto-β-boswellic acid (KBA) and α-boswellic acid (αBA) in B. carteri resin were quantified using high‑performance liquid chromatography analysis. Results: Maximum amounts of KBA and αBA in B. carteri resin were obtained using 6% acetic acid for 10 min at 90°C in preliminary test. Two factor interactions, such as acetic acid concentration– heating temperature and heating temperature–heating time, were significantly observed by multiple regression analysis. Optimal processing conditions from RSM were 5.83% for acetic acid concentration, 9.56 min for heating time, and 89.87°C for heating temperature. Under the modified conditions, the experimental value of the response was 11.25 mg/g, which was similar to the predicted value. Conclusions: The results suggest that the optimal conditions for the stir‑baking process of B. carteri resin were determined by RSM, which was reliable and applicable to practical processing of herbal medicine.

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      Yoon, J., Kim, J., Ham, S., Gang, B., Lee, S., Choi, G., Kim, Y., Lee, G., & Ju, Y. (2018). Optimal Processing Conditions of Boswellia carteri Birdw. Using Response Surface Methodology. Pharmacognosy Magazine, 14(54), 235–241. https://doi.org/10.4103/pm.pm_140_17