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    Antioxidant, Anti‑inflammatory, and Antiproliferative Activity of Extracts Obtained from Tabebuia Rosea (Bertol.) DC

    Francisco Javier Jiménez‑González2, Jenny Marcela Vélez‑Gómez2, Jhon Jairo Melchor‑Moncada3, Luz Angela Veloza2, Juan Carlos Sepúlveda‑Arias3★★ Corresponding author

    1. 1Facultad de Tecnología, Escuela de Tecnología Química, Grupo Polifenoles, Universidad Tecnológica de Pereira.
    2. 2Departamento de Ciencias Básicas, Facultad de Ciencias de La Salud, Grupo Infección e Inmunidad, Universidad Tecnológica de Pereira, Pereira, Colombia.

    CORRESPONDENCE

    Juan Carlos Sepúlveda‑Arias

    jcsepulv@utp.edu.co

    Received: 29-12-2017; Revised: 15-02-2018.

    Volume 14, Issue 55s · pp. S25–S31 · PUBLISHED 28 June 2018 · DOI: 10.4103/pm.pm_624_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Tabebuia rosea (Bertol.) DC. is a neotropical tree used in traditional medicine in the Northern coast of Colombia as well as Latin America for infectious diseases treatment. Few studies have evaluated the biological activity of this species. Objective: The objective of this study is to determine the antioxidant, anti‑inflammatory, and antiproliferative potential of leaf and inner bark extracts from T. rosea. Materials and Methods: The antioxidant activity was determined using the 2,2‑diphenyl‑1‑picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) methods. The anti‑inflammatory activity was evaluated in lipopolysaccharide‑stimulated murine macrophages. In vitro antiproliferative effect was determined in HepG2, HeLa, MCF‑7, and B16F10 cell lines. Results: The highest DPPH radical scavenging activity was observed for T. rosea ethyl acetate leaf extract (IC50 of 157.5 ± 2.4 µg/mL). This extract also induced the best antioxidant activity as determined by ORAC (11,112.2 ± 1,255.3 µmol TE/g of extract). Moreover, T. rosea leaf n‑hexane, chloroform, and aqueous extracts, in addition to inner bark aqueous extract did inhibit nitric oxide production by over 90%. In addition, inner bark extracts markedly inhibited prostaglandins E2 and tumor necrosis factor alpha (>90%). The best antiproliferative activity was displayed by the inner bark chloroform extract against HepG2 (selectivity index [SI] = 5.50) and B16F10 (SI = 3.18) cell lines. Conclusion: These results demonstrate the potential biological activity of T. rosea extracts.

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      Jiménez‑González, F. J., Vélez‑Gómez, J. M., Melchor‑Moncada, J. J., Veloza, L. A., & Sepúlveda‑Arias, J. C. (2018). Antioxidant, Anti‑inflammatory, and Antiproliferative Activity of Extracts Obtained from Tabebuia Rosea (Bertol.) DC. Pharmacognosy Magazine, 14(55s), S25–S31. https://doi.org/10.4103/pm.pm_624_17