Volume 14, Issue 55s

DNA Barcode Testing in Authentication of Botanical Raw Material Coming of Age

D. B. A. Narayana, T. Sudhakar Johnson

pp. S1–2 · DOI: 10.4103/pm.pm_249_18 · Published 2018

Evaluation and Understanding the Molecular Basis of the Antimethicillin‑Resistant Staphylococcus aureus Activity of Secondary Metabolites Isolated from Lamium amplexicaule

Mohammed M. Ghoneim, Arafa Musa, Atef A. El‑Hela, Khaled M. Elokely

pp. S3–S7 · DOI: 10.4103/pm.pm_541_17 · Published 28 June 2018

Background: The genus Lamium includes about forty annual or perennial plants distributed everywhere, it has significant biological activities including antimicrobial, antioxidant and antischistosomal effects. However, no…

Quinic Acid Attenuates Oral Cancer Cell Proliferation by Downregulating Cyclin D1 Expression and Akt Signaling

Anjana Singh, Shyam Singh Chauhan, Vishwas Tripathi

pp. S14–S19 · DOI: 10.4103/pm.pm_36_18 · Published 28 June 2018

Background: Quinic acid (QA), a natural compound found in fruits, for example in apple, berries, and coffee beans, is a neutraceutical chiral compound used to synthesize new pharmaceutically important chemical compounds.…

Antioxidant, Anti‑inflammatory, and Antiproliferative Activity of Extracts Obtained from Tabebuia Rosea (Bertol.) DC

Francisco Javier Jiménez‑González, Jenny Marcela Vélez‑Gómez, Jhon Jairo Melchor‑Moncada, Luz Angela Veloza, Juan Carlos Sepúlveda‑Arias

pp. S25–S31 · DOI: 10.4103/pm.pm_624_17 · Published 28 June 2018

Background: Tabebuia rosea (Bertol.) DC. is a neotropical tree used in traditional medicine in the Northern coast of Colombia as well as Latin America for infectious diseases treatment. Few studies have evaluated the bio…

Insulinotropic and Cytoprotective Effect of L-theanine: An In vitro Dose Dependent Study

Arpita Saha, Sirshendu Chatterjee, Ananya Chatterjee, Surmi Roy, Nirmalya Roy, Satinath Mukhopadhyay

pp. S36–S39 · DOI: 10.4103/pm.pm_595_17 · Published 28 June 2018

Background: L‑theanine is a natural bioactive amino acid present in tea (Camellia sinensis [L.] O. Kuntze) and consumed worldwide through tea decoction. Objective: The present work aims at evaluation of the insulin secre…

Nontargeted Analysis and Cancer Cells Cytotoxicity of Aegle marmelos Correa Ex Roxb.

Sachin Kumar, Dr. Ramesh Babu Bodla

pp. S40–S44 · DOI: 10.4103/pm.pm_264_17 · Published 28 June 2018

Background: Aegle marmelos belongs to the family Rutaceae, a medium‑sized perennial tree which grows in subtropical and tropical parts of India and South‑East Asia. Studies have reported that leaf extracts of A. marmelos…

Molecular Authentication of Trichosanthes Species Traded as “Patola:” An Ayurvedic Drug Resource

Bhagyashri Kumbhalkar, Anuradha Upadhye, Shubhada Tamhankar

pp. S52–S56 · DOI: 10.4103/pm.pm_242_17 · Published 28 June 2018

Background: Different interpretations of ayurvedic texts have recognized/recommended taxonomically distinct species/varieties of Trichosanthes as “Patola,” which is used extensively in the Indian traditional system of me…

Ameliorative Effect of Quercetin and Rutin via Modulation of Hypothalamic–Pituitary–Adrenal Axis and Regulation of Fasting Glucose in Chronic Stress‑Induced Prediabetes

Mustajab Quraishi, Santosh N. Mokale, Nikhil S. Sakle

pp. S65–S71 · DOI: 10.4103/pm.pm_323_17 · Published 28 June 2018

Background: Quercetin (QUE) and Rutin (RUT) have nutritive and medicinal values. On the other hand, there are no reports of scientific assessment of its hypothalamo–pituitary–adrenal (HPA) axis modulation in the treatmen…

A Rapid High‑performance Liquid Chromatography Method for the Simultaneous Estimation of Water‑soluble Vitamin in Ten Wild Edible Plants Consumed by the Tribal People of North‑eastern Region in India

Tapan Seal, Kausik Chaudhuri, Basundhara Pillai

pp. S72–S77 · DOI: 10.4103/pm.pm_481_17 · Published 28 June 2018

Background: Bauhinia purpurea, Clerodendrum colebrookianum, Dillenia pentagyna, Diplazium esculentum, Houttuynia cordata, Oenanthe linearis, Potentilla lineata, Perilla ocimoides, Sonchus arvensis, and Zanthoxylum acanth…

High‑performance Liquid Chromatography Identification of Gastroprotective and Antioxidant Effects of Purified Fractions A‑E from the Stem of Coscinium fenestratum

Hui Yang, Hong-Bin Zhai, Wei-Min Wang, Okechukwu Patrick Nwabueze

pp. S78–S83 · DOI: 10.4103/pm.pm_267_17 · Published 28 June 2018

Objective: Coscinium fenestratum belongs to the family of Menispermaceae. It is a woody plant that originated from Indomalaya regions such as southern India, Sri Lanka, Thailand, Vietnam, Cambodia, and West Malaysia. C. …

Alliin the Precursor of Allicin in Garlic Extract Mitigates Proliferation of Gastric Adenocarcinoma Cells by Modulating Apoptosis

Debjani P. Mansingh, Nibedita Dalpati, Veeresh Kumar Sali, A. Hannah Rachel Vasanthi

pp. S84–S91 · DOI: 10.4103/pm.pm_342_17 · Published 28 June 2018

Background: Garlic, a common spice used since time immemorial for various purposes, is considered a potential functional food as it exhibits cardioprotection to chemoprevention properties due to the presence of organosul…

Rubus sanctus Schreb. Root Extract Alters the MicroRNA Expression and Inhibits Tumor Activities of Colorectal Cancer Cell Lines

Adem Alemdar, Berrin Tunca, Hulusi Malyer, Saliha Sahin

pp. S92–101 · DOI: 10.4103/pm.pm_357_17 · Published 28 June 2018

Background: Colorectal cancer (CRC) is one of the most common cancers in the world. Although surgical and screening techniques have vastly improved in the last 30 years, chemotherapeutics have not advanced sufficiently f…

Molecular Interaction of Naringin and Its Metabolite Naringenin to Human Liver Fibrosis Proteins: An In Silico Approach

V. J. Shine, G. I. Anuja, S. Pradeep, S. R. Suja

pp. S102–S109 · DOI: 10.4103/pm.pm_453_17 · Published 28 June 2018

Background: Naringin, pharmaceutically active flavonoid, rapidly metabolizes in liver into naringenin. Both naringin and naringenin have significant biological activity and less toxicity. Objective: In the present study,…

Taxifolin Possesses Anti‑Cancer Activity on the 7,12‑Dimethylbenz(a)anthracene‑Induced Breast Cancer in the Sprague Dawley Rats by Remodeling Nuclear Factor Erythroid 2‑ Kelch‑Like ECH‑Associated Protein 1‑Heme Oxygenase 1 and Anti‑Oxidant Pathways

Md. Wasimul Haque, Mohd. Usman Mohd Siddique, Pritha Bose, Shakti Prasad Pattanayak

pp. S110–S117 · DOI: 10.4103/pm.pm_601_17 · Published 28 June 2018

Background: In mammary cancer, alterations in various gene expressions and signaling pathways occurs due to the secondary effects of oxidative stress that facilitates cancer by causing genomic instability and mutagenic a…

Effects of Beta‑sitosterol on Isolated Human Non-Pregnant Uterus in Comparison to Prostaglandin E2

Cristina Occhiuto, Domenico Trombetta, Antonella Smeriglio, Emanuele Sturlese, Francesco Occhiuto

pp. S118–S122 · DOI: 10.4103/pm.pm_163_17 · Published 28 June 2018

Background: Beta‑sitosterol (β‑sitosterol) is one of the several phytosterols widely studied for its potential to reduce benign prostatic hyperplasia and blood cholesterol levels. Objective: In the present study, the eff…

Simultaneous Quantification of Precocene I and Precocene II through High‑performance Thin Layer Chromatography Validated Method in Ageratum conyzoides L. Germplasms from Western Himalayas

Bhanu Kumar, Ankita Misra, Ajay Kumar Singh Rawat, Yashwant Singh Rawat, Sharad Srivastava

pp. S141–S146 · DOI: 10.4103/pm.pm_411_17 · Published 28 June 2018

Background: Ageratum conyzoides L. is a traditionally used herb for various ethnoveterinary purposes. There are no earlier reports on simultaneous high‑performance thin layer chromatography (HPTLC) quantification of bioa…

Intercomparative Investigation of the Total Phenols, Total Flavonoids, In vitro and In vivo Antioxidant Activities of Capparis Cartilaginea (Decne.) Maire and Weiller and Capparis Ovata Desf. from Jordan

Mahmoud A. Al‑Qudah, Safwan M. Obeidat, Riyadh Muhaidat, Bahaa Al‑Trad, Hala I. Al‑Jaber, Jamil N. Lahham

pp. S154–S160 · DOI: 10.4103/pm.pm_356_17 · Published 28 June 2018

Background: Plant‑derived antioxidants have been products of choice in therapeutic formulations for their potent free radical scavenging activity and mitigating and curing illnesses and diseases associated with oxidative…

Pharmacokinetic Study on Piplartine and Piperine after Oral Administration of Piper chaba Root by Liquid Chromatography‑mass Spectrometry/mass Spectrometry

P. R. Rao Vadaparthi, Kumar Katragunta, A. K. M. Pawar, Suresh Babu Katragadda, Ashok K. Tiwari, Madhusudana Kuncha

pp. S161–S166 · DOI: 10.4103/pm.pm_470_17 · Published 28 June 2018

Background: Piperaceae family are a well‑known source of structurally diverse amides with the wide range of bioactivities such as cytotoxic, stomach aches, insect repellents, anti‑inflammatory, insecticidal, and antifeed…

6-Gingerol Prevents Free Transition Metal Ion [Fe (Ii)] Induced Free Radicals Mediated Alterations by In vitro and Ndv Growth in Chicken Eggs by In ovo

Ganjikunta Venkata Subbaiah, Kesireddy Sathyavelu Reddy, Yagani JayavardhanaRao, Bhasha Shanmugam, Sahukari Ravi, Kondeti.Ramudu Shanmugam, Golla Narasimha

pp. S167–S174 · DOI: 10.4103/pm.pm_387_17 · Published 28 June 2018

Background: The study of free radicals and their reactions is implicated in the pathogenesis of various human diseases. Therefore, antioxidants treatment plays a pivotal role in preventing the free radical‑induced diseas…

Lipid‑lowering Effect of Hydroalcoholic Extracts of Gynura procumbens in Chemical‑ and High‑fat Diet‑induced Hyperlipidemic Rats

Vikneswaran Murugaiyah, Mohammed Ali Ahmed Saeed, Yow-Meng Kuong, Kisantini Murugesu, Subramani Parasuraman, Mohd. Zaini Asmawi, Amirin Sadikun

pp. S184–S191 · DOI: 10.4103/pm.pm_451_17 · Published 28 June 2018

Objective: The present study was carried out to investigate lipid‑lowering effect of hydroalcoholic extracts of Gynura procumbens in chemical‑ and high‑fat diet (HFD)‑induced hyperlipidemic rats. Materials and Methods: T…

A Therapeutic Approach to Target Mitochondrial Dysfunction using Molecular Docking Studies: Screening of Natural Drugs for Oral Carcinoma

Manish Singh, Manish Kumar Tripathi, Alok Kumar Singh, Chandra Shekhar Azad, Indrajeet Singh Gambhir

pp. S192–S196 · DOI: 10.4103/pm.pm_471_17 · Published 28 June 2018

Background: Mitochondrial dysfunction is the major cause of various types of cancer, leading to death worldwide. The present study investigated the in silico binding potential of natural flavonoids and essential oils wit…

Naringin Ameliorates Doxorubicin‑induced Neurotoxicity In vitro and Cognitive Dysfunction In vivo

Grandhi Venkata Ramalingayya, Pawan G. Nayak, Rekha R. Shenoy, Sanchari Basu Mallik, Karthik Gourishetti, Shalam M. Hussain, Chamallamudi Mallikarjuna Rao, Krishnadas Nandakumar

pp. S197–S207 · DOI: 10.4103/pm.pm_364_17 · Published 28 June 2018

Objectives: The primary objective of the study was to study the neuroprotective potential of naringin (NAR) against doxorubicin (DOX)‑induced neurotoxicity in vitro and DOX‑induced cognitive deficits (chemobrain) in vivo…

Biological Effects of Salvia Officinalis Leaf Extract on Murine Myeloma Cells

Elisa Ovidi, Doriana Triggiani, Maria Valeri, Fabio Mastrogiovanni, Laura Salvini, Claudia Bonechi, Anna Rita Taddei

pp. S208–S212 · DOI: 10.4103/pm.pm_401_17 · Published 28 June 2018

Background: In the Mediterranean region, Salvia officinalis plant is widely used and routinely added to food for a traditional culinary utilization, and moreover, from long time, it is recognized to possess pharmacologic…

Effect of Simvastatin on Neuroinflammation in Microglial Cells Via Mitogen‑activated Protein Kinase and Nuclear Factor κB Pathways

HongYing Ma, DingAn Li, Thamaraiselvan Rengarajan, Kalaivani Manokaran

pp. S237–S244 · DOI: 10.4103/pm.pm_418_17 · Published 1 March 2018

Background: Activated microglial cells are found in different sorts of the neurodegenerative process including Parkinson and Alzheimer. Suppressing the activated microglial cells developed as a novel procedure for the tr…

A Novel Compound Lup‑20 (29)‑ene‑3α,6β‑diol Identified in Petroleum Ether Extract of Diospyros melanoxylon Roxb. Leaves and to Reveal Its Antidiabetic Activity in Rats

Anil Kumar Sharma, Tek Chand Sharma, Ruchi Singh, Pratibha Payal, Rajnish Gupta, Mahesh Chandra Sharma

pp. S245–S248 · DOI: 10.4103/pm.pm_429_17 · Published 28 June 2018

Background: Diospyros melanoxylon Roxb. belongs to the family Ebenaceae and its leaves show diuretic, carminative, laxative, and styptic bioactivities. Objective: The objective of this study was to give a direction for f…

Formulation Design and Evaluation of an Emulgel Containing Terminalia arjuna Bark Extract for Transdermal Delivery

Dinanath Tukaram Gaikwad, Namdeo Ramhari Jadhav

pp. S249–S255 · DOI: 10.4103/pm.pm_578_17 · Published 28 June 2018

Background: Terminalia arjuna is used in various indigenous system of medicine such as Ayurveda, Siddha, and Unani. The traditional medical forms provide drug delivery with peaks often above the required dose and face pr…

Effect of Aqueous/Methanolic Extract of Ocimum sanctum (OciBest) on the Male and Female Reproductive Performance of Wistar Rats

Raina P, B. Bharathi, A. Senthilkumar, S. Sagar, C. V. Chandrasekaran, D. Prabhu, M. Deepak, A. Amit

pp. S256–S263 · DOI: 10.4103/pm.pm_562_17 · Published 28 June 2018

Background: Ocimum sanctum (OSE) has been used in the Indian system of traditional medicine (Ayurveda) for the treatment and prevention of various diseases. However, the contradictory reports regarding the reproductive s…

Evaluation of Aphrodisiac Activity of AHPL/AYCAP/0114 Capsule in Sexually Sluggish Male Rats

Sanjay U. Nipanikar, Dheeraj H. Nagore, Sohan S. Chitlange

pp. S264–S267 · DOI: 10.4103/pm.pm_363_17 · Published 28 June 2018

Background: Male sexual dysfunction includes a wide range of problems such as erectile dysfunction and premature ejaculation, for which medical help is sought. The conventional use of various pharmacological and nonpharm…

Comparative Effects of Metformin, Pleurotus ostreatus, Nigella Sativa, and Zingiber officinale on the Streptozotocin‑induced Diabetes Mellitus in Rats

Sibghatullah Muhammad Ali Sangi, Abdulhakim Bawadekji, Mouhanad Al Ali

pp. S268–S273 · DOI: 10.4103/pm.pm_108_18 · Published 28 June 2018

Background: Diabetes mellitus (DM) is a heterogeneous metabolic disorder occurring due to absolute or relative deficiency of insulin and causing chronic hyperglycemia that leads to crippling complications associated with…

Media Standardization for Enhanced Production of Bacoside of Bacopa monnieri In situ Condition

Pratibha Anil Chaturvedi, Lal Hingorani

pp. S32–5 · DOI: 10.4103/pm.pm_328_17 · Published 28 June 2018

Background: Secondary metabolites are known to not only play a major role in the adaptation of plants to their environment but also represent an important source of active pharmaceuticals Accumulation of such metabolites…

High performance Thin Layer Chromatography-Automated Multiple Development Bioautography of Phytoconstituents and Quantification of Stigmasterol in Monochoria vaginalis and Monochoria hastata with Antioxidant Potential

Narayanan Kasthuri Bai, Kaliappan Ilango

pp. S45–51 · DOI: 10.4103/pm.pm_71_17 · Published 28 June 2018

Context: Monochoria vaginalis and Monochoria hastata belonging to Pontederiaceae are edible aquatic herbs commonly used by ethnic communities of India for treating various afflictions. Objective: The main objective of th…

5,7‑Dihydroxy‑4‑Methoxyflavone a Bioactive Flavonoid Delays Amyloid Beta‑induced Paralysis and Attenuates Oxidative Stress in Transgenic Caenorhabditis elegans

Jyotsna Asthana, B. N. Mishra, Rakesh Pandey

pp. S57–64 · DOI: 10.4103/pm.pm_290_17 · Published 28 June 2018

Background: The various herbal remedies have been used in Ayurveda which symbolizes traditional medicine system since ancient times. The increasing popularity of herbal medicines has prompted us toward the development of…

Therapeutic Potential of Boerhavia diffusa L. against Cyclosporine A‑Induced Mitochondrial Dysfunction and Apoptosis in Madin–Darby Canine Kidney Cells

M. K. Kalaivani, Sumathy Arockiasamy, Cordelia John, Hannah Rachel Vasanthi, P. Soundararajan

pp. S132–40 · DOI: 10.4103/pm.pm_383_17 · Published 28 June 2018

Introduction: Cyclosporine A (CsA), a calcineurin inhibitor, causes chronic nephrotoxicity during organ transplantation. Objective: The aim is to investigate the effect of ethyl acetate fraction (EF) of Boerhavia diffusa…

Green Synthesis and Antioxidant Analysis of In vivo Leaf and In vitro Callus of Tephrosia villosa

V. Ranjitha, K. Kalimuthu, V. Chinnadurai, Y. Sharmila Juliet, M. Saraswathy

pp. S147–S153 · DOI: 10.4103/pm.pm_64_17 · Published 28 June 2018

Background: Tephrosia villosa (Leguminosae) is an important medicinal plant widely used in traditional Indian medicine. To the best of our knowledge, there is no report on this field. Objective: The aim of this study was…

Anticoagulant, Antiplatelet and Fibrin Clot Hydrolyzing Activities of Flax Seed Buffer Extract

Sharath Kumar M. Nandish, Jayanna Kengaiah, Chethana Ramachandraiah, Ashwini Shivaiah, Chandramma, Kesturu S. Girish, Kempaiah Kemparaju, Devaraja Sannaningaiah

pp. S175–83 · DOI: 10.4103/pm.pm_320_17 · Published 28 June 2018

Background: Flax seeds possess long array of medicinal qualities as it found to show beneficial effects on cardiovascular, hypertension, diabetes, cancer, inflammatory and autoimmune disorders. While, the therapeutic rol…

Development of Internet Technology TIPHAM (Tool for identity of Powdered Herbals through Analytical Microscopy) for Microscopic Identification of Crude Herbal Drugs

Dharya Singh, Vidhu Aeri, D. B. Ananthanarayana

pp. S213–26 · DOI: 10.4103/pm.pm_563_17 · Published 28 June 2018

Background: Industrial usage of herbal plants has gone up, but techniques for verifying their botanical identity is still questionable. In the herbal industry, bulk consignments are received in powdered form as it is cum…

Prophylactic Treatment with Icariin Prevents Isoproterenol‑Induced Myocardial Oxidative Stress via Nuclear Factor‑Like 2 Activation

Sumit Sharma, Vasim Khan, Abul Kalam Najmi, Ozair Alam, Syed Ehtaishamul Haque

pp. S227–36 · DOI: 10.4103/pm.pm_469_17 · Published 28 June 2018

Introduction: Icariin, a major component of Epimedium species and a mild phosphodiesterase 5 (PDE‑5) inhibitor, was evaluated for the prevention of myocardial oxidative stress in isoproterenol (ISO)‑challenged Wistar rat…