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    Ginsenoyne C, a Polyacetylene Isolated from Panax Ginseng Inhibit Inflammatory Mediators via Regulating Extracellular Regulated Kinases Signaling

    Sun‑Yup Shim1, Sang Hyun Sung2, Mina Lee1★★ Corresponding author

    1. 1Department of Pharmacy, College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon‑si 57922, Jeonnam.
    2. 2Department of Pharmacy, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 599 Gwanak‑ro, Gwanak‑gu, Seoul 08826, Republic of Korea.

    CORRESPONDENCE

    Mina Lee

    Department of Pharmacy, College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon‑si 57922, Jeonnam.

    minalee@sunchon.ac.kr

    Received: 02-03-2018; Revised: 20-07-2018.

    Volume 14, Issue 57s · pp. S358–S362 · PUBLISHED 10 September 2018 · DOI: 10.4103/pm.pm_58_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Panax ginseng has been used as a traditional medicine for various pathological conditions. Ginsenoyne C (GSC) is a polyacetylene, minor constituent. Objective: The objective of the present study was to determine the anti‑inflammatory activities of GSC for the protection of inflammation. Materials and Methods: The effects of GSC on cell viability and nitric oxide (NO) production in lipopolysaccharide (LPS)–induced RAW 264.7 cells were investigated through MTT assay and the Griess reaction, respectively. The levels of inflammatory cytokines such as interleukin (IL‑1β) and IL‑6 and inducible NO synthase (iNOS), cyclooxygenase‑2 (COX‑2), and pERK were measured using enzyme‑linked immunosorbent assay and Western blot analysis, respectively. Results: GSC suppressed NO production in LPS‑induced RAW 264.7 cells. GSC suppressed the production of inflammatory mediators through downregulating phosphorylation of extracellular regulated kinases signaling in LPS‑induced RAW 264.7. Conclusion: GSC has a potential therapeutic agent for protection of inflammation.

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      Shim, S., Sung, S. H., & Lee, M. (2018). Ginsenoyne C, a Polyacetylene Isolated from Panax Ginseng Inhibit Inflammatory Mediators via Regulating Extracellular Regulated Kinases Signaling. Pharmacognosy Magazine, 14(57s), S358–S362. https://doi.org/10.4103/pm.pm_58_18