Efficacy and Safety of Herbal Formulation Rich in Standardized Fenugreek Seed Extract as Add‑on Supplementation in Patients with Type 2 Diabetes Mellitus on Sulfonylurea Therapy: A 12‑week, Randomized, Double‑blind, Placebo‑controlled, Multi‑center Study

ABSTRACT

Background: Type 2 diabetes mellitus (T2DM) is a chronic, complex, and progressive illness that often needs combination therapy for better glycemic control. IDM1, an herbal formulation which is rich in standardized fenugreek seed extract. Aim: The aim of this study is to evaluate the efficacy and safety of add‑on therapy of IDM1 in T2DM patients inadequately controlled on sulfonylurea monotherapy. Materials and Methods: In this 12‑week, randomized, double‑blind, placebo‑controlled, multi‑centric study, T2DM patients which inadequate glycemic control with background stable dose medication of sulfonylurea was screened (n = 120). The patients were randomized 1:1 to add‑on therapy of IDM1 and placebo, 700 mg three times daily for 12 weeks. Results: A total of 119 patients were randomized and included in the efficacy analysis (IDM1, n = 60; placebo, n = 59). At week 12, adjusted fasting plasma glucose (FPG) (20 mg%), postprandial plasma glucose (PPPG) (26 mg%), and glycated hemoglobin (HbA1c) (0.9 mg%) was reduced significantly (P < 0.05) from baseline as compared to placebo group (FPG: 7 mg%; PPPG: 4 mg% and HbA1c: 0.4 mg%). These beneficial effects were seen as early as 1 month after consumption of IDM1 and continued until at least 15 days after withdrawal of IDM1. Hypoglycemic events were mostly mild, and none required emergency treatment. There were no major changes in body weight, hematology, and biochemistry at week 12 as compared to baseline. Overall AEs rates were similar in both groups. Conclusions: IDM1 is a safe, effective, and well‑tolerated add‑on oral medication therapy that supports healthy blood sugar levels and glycosylated hemoglobin levels in T2DM patients inadequately controlled with a sulfonylurea.

KEYWORDS

• Add‑on therapy
• glycemic control
• glycated hemoglobin
• standardized fenugreek seed extract
• sulfonylureas
• type 2 diabetes

Showing references and in-text citations exactly as published.

• DOI10.4103/pm.pm_260_18Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Mag..

• Article · VOLUME 14, ISSUE 57SSolvent‑based Microwave‑assisted Extraction and Identification of Bioactive Compounds from Sesamum indicum Leaves using Particle Swarm Optimization‑integrated Response Surface MethodologyLopamudra Sarma, Sourav Chakraborty, Raj Kumar Duary · pp. S275–S283Original ArticleSame type: Article
• Article · VOLUME 14, ISSUE 57SEvaluation of Antiangiogenic Potential of Psidium guajava Leaves using In‑Ovo Chick Chorioallantoic Membrane AssayS. Latha, P. Yamini, Rajani Mathur · pp. S284–S293Original ArticleSame type: Article
• Article · VOLUME 14, ISSUE 57SIn vitro Antioxidant and Anticancer Activities of Leaf Extracts of Rhododendron arboreum and Rhododendron campanulatum from Uttarakhand Region of IndiaSakshi Painuli, Swati Joshi, Anuja Bhardwaj, Ramesh Chand Meena, Kshipra Misra, Nishant Rai, Navin Kumar · pp. S294–S303Original ArticleSame type: Article
• Article · VOLUME 14, ISSUE 57SFlavonoid and Phenolic Compounds from Carissa macrocarpa:Molecular Docking, Cytotoxicity Studies Hany E. Khalil, Maged E. Mohamed, Mohamed A. Morsy, Mahmoud Kandeel · pp. S304–S310Original ArticleSame type: Article