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    Comparative Studies of Selected Calophyllum Plants for their Anti‑inflammatory Properties

    Siau Hui Mah1★, Soek Sin Teh2, Gwendoline Cheng Lian Ee3★ Corresponding author

    1. 1School of Biosciences, Taylor’s University, Lakeside Campus, Subang Jaya.
    2. 2Engineering and Processing Division, Energy and Environment Unit, Malaysian Palm Oil Board, Kajang.
    3. 3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor, School of Biosciences, Taylor’s University, Lakeside Campus, Subang Jaya, Malaysia.

    CORRESPONDENCE

    Siau Hui Mah

    School of Biosciences, Taylor’s University, Lakeside Campus, Subang Jaya.

    siauhui.mah@taylors.edu.my

    Received: 26-04-2018; Revised: 23-05-2018.

    Volume 15, Issue 60 · pp. 135–139 · PUBLISHED 23 January 2019 · DOI: 10.4103/pm.pm_212_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Calophyllum (Clusiaceae) plants have been used as traditional medicine for rheumatism, vein problems, hemorrhoids, and gastric ulcers. The traditional uses of this genus prompted us to investigate six Malaysian Calophyllum species which are Calophyllum inophyllum, Calophyllum soulattri, Calophyllum lowii, Calophyllum teysmannii, Calophyllum benjaminum and Calophyllum javanicum for their anti‑inflammatory properties. Materials and Methods: The stem bark of six plants was extracted with n‑hexane (Hex), ethyl acetate (EA), and methanol (MeOH). The activities of the extracts were evaluated by determining the inhibition of nitric oxide (NO) production by lipopolysaccharide‑induced RAW 264.7 cells, as well as protein denaturation. Results and Discussion: The C. lowii extracts showed the most significant activities against NO production with IC50 values of <40 µg/ mL. For the protein denaturation test, C. teysmannii extracts showed the strongest effect with IC50 values of <100 µg/mL. The results indicated that C. lowii and C. teysmannii are effective in both assays. Besides, the Hex extracts of these Calophyllum plants possess stronger activities than the EA and MeOH extracts. The anti‑inflammatory properties are contributed by the secondary metabolites present in the crude extracts, specifically flavonoid, triterpenes, and xanthones. Conclusion: These results confirm the potential of Calophyllum plants to serve as lead agents in preventing inflammation.

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      Mah, S. H., Teh, S. S., & Ee, G. C. L. (2019). Comparative Studies of Selected Calophyllum Plants for their Anti‑inflammatory Properties. Pharmacognosy Magazine, 15(60), 135–139. https://doi.org/10.4103/pm.pm_212_18