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    Article

    Optimization of Ultrasonic‑Assisted Extraction of Bioactive Compounds from Sargassum henslowianum using Response Surface Methodology

    Yongguang Bi2,3★, Yanshan Lu2, Hong Yu2, Lili Luo2★ Corresponding author

    1. 1Department of Pharmaceutical Engineering, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
    2. 2State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Hainan, Haikou, China.

    CORRESPONDENCE

    Yongguang Bi

    State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Hainan, Haikou, China.

    biyongguang2002@163.com

    Received: 08-07-2018; Revised: 16-08-2018.

    Volume 15, Issue 60 · pp. 156–163 · PUBLISHED 23 January 2019 · DOI: 10.4103/pm.pm_347_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: This study was to optimize the ultrasound‑assisted extraction of polysaccharides and polyphenols from S. henslowianum and test the biological activity of the extract. Materials and Methods: Response surface methodology was used to optimize extraction conditions, and the antioxidant activity of the extracts was evaluated by radical scavenging assay, α‑Glucosidase inhibition, and cytotoxicity on MCF‑7. Results: The optimal conditions of extracting polysaccharides were shown as following: ultrasonic time for 40 min, ultrasonic power for 330 W, solid‑to‑liquid ratio for 1:36 g/mL, the extraction yield reached 12.63% under above parameters. The optimum conditions of ultrasonic‑assisted extraction of total polyphenols were as following: ultrasonic time for 102 min, ultrasonic power for 377 W, alcohol concentration for 62%, under these conditions, the extraction yield reached 11.45%. Besides, the extracts of polyphenols possessed stronger activity. Conclusion: This study provides the scientific guidance for further exploitation and utilization of S. henslowianum.

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      Bi, Y., Lu, Y., Yu, H., & Luo, L. (2019). Optimization of Ultrasonic‑Assisted Extraction of Bioactive Compounds from Sargassum henslowianum using Response Surface Methodology. Pharmacognosy Magazine, 15(60), 156–163. https://doi.org/10.4103/pm.pm_347_18