Anti‑Inflammatory Activity of Corylopsis coreana Uyeki Extracts and Isolated Compounds by Inhibiting Nitric Oxide and Cytokine Production
Jun Yin1, HyeSoo Wang1, MinWon Lee1★★ Corresponding author
- 1Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung‑Ang University, Seoul, Republic of Korea ORIGINAL ARTICLE.
CORRESPONDENCE
MinWon Lee
Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung‑Ang University, Seoul, Republic of Korea ORIGINAL ARTICLE.
Received: 09-04-2018; Revised: 08-05-2018.
Volume 15, Issue 61 · pp. 317–321 · PUBLISHED 6 March 2019 · DOI: 10.4103/pm.pm_144_18
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ABSTRACT
Aims: To study the anti‑inflammatory effects of C. coreana Uyeki leaf and bark extracts as well as their major active compounds, we evaluated in vitro levels of tumor necrosis factor‑α (TNF‑α), interleukin‑6 (IL‑6), and nitric oxide (NO) using RAW 264.7 macrophages. Materials and Methods: Production of TNF‑α and IL‑6 cytokines was measured by ELISA assay, and NO inhibitory activity was tested by Griess assay. Results: Extracts of leaves and barks, as well as isolated compounds from these extracts, showed remarkable anti‑inflammatory activities by inhibiting NO, TNF‑α, and IL‑6 cytokine production. In particular, the leaf extract showed more potent inhibitory activities than that of barks. Conclusions: Ellagitannins and flavonoids were probably related to the anti‑inflammatory activity of CL (leaves) extract, providing evidence of the anti‑inflammatory property of CL.
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Yin, J., Wang, H., & Lee, M. (2019). Anti‑Inflammatory Activity of Corylopsis coreana Uyeki Extracts and Isolated Compounds by Inhibiting Nitric Oxide and Cytokine Production. Pharmacognosy Magazine, 15(61), 317–321. https://doi.org/10.4103/pm.pm_144_18