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    Article

    Effects of the Herbal Medicines on Voltage‑Dependent K+ 2 Channels

    Jeong Nam Kim1, Eun Yeong Lim2,3, Yun Tai Kim2,3, Hyungwoo Kim4, Byung Joo Kim1★★ Corresponding author

    1. 1Division of Longevity and Biofunctional Medicine and Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University.
    2. 2Research Group of Innovative Special Food, Korea Food Research Institute, Wanju‑gun.
    3. 3Department of Food Biotechnology, Korea University of Science and Technology, Daejeon, Korea.
    4. 4Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan.

    CORRESPONDENCE

    Byung Joo Kim

    Division of Longevity and Biofunctional Medicine and Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University.

    vision@pusan.ac.kr

    Received: 17-12-2018; Revised: 19-03-2019.

    Volume 15, Issue 63 · pp. 369–377 · PUBLISHED 16 May 2019 · DOI: 10.4103/pm.pm_636_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The aim of this study was to evaluate whether herbal medicines, such as the fruit of Schisandra chinensis (SCF), Atractylodes macrocephala Koidzumi (AMK), Poria cocos Wolf (PCW), Citrus unshiu peel (CUP), Magnolia officinalis Bark (M. officinalis), Alisma canaliculatum (A. canaliculatum), Rehmanniae Radix (RR), and Corni fructus (C. fructus), modulate Kv2 channels and cause insulin secretion. Materials and Methods: We used the whole‑cell patch‑clamp technique to analyze the effect of these herbal medicines on Kv channels. In addition, human embryonic kidney 293 cells overexpressing Kv2.1 and Kv2.2 channels were used to confirm the role of Kv2 channels. Results: SCF, AMK, PCW, CUP, M. officinalis, A. canaliculatum, and RR inhibited Kv2.1 channel currents in a concentration‑dependent manner (100–500 μg/mL). However, C. fructus had no effects on Kv2.1 channel currents. In addition, SCF, AMK, M. officinalis, and A. canaliculatum inhibited Kv2.2 channel currents in a concentration‑dependent manner, but PCW, CUP, and RR had no effects on Kv2.2 channel currents. Furthermore, RR, CUP, and PCW increased insulin secretion. Conclusion: These findings suggested that the herbal medicines, RR, CUP, and PCW, are potential novel agents for the prevention and treatment of diabetes.

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      Kim, J. N., Lim, E. Y., Kim, Y. T., Kim, H., & Kim, B. J. (2019). Effects of the Herbal Medicines on Voltage‑Dependent K+ 2 Channels. Pharmacognosy Magazine, 15(63), 369–377. https://doi.org/10.4103/pm.pm_636_18