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    Article

    Research on Mechanism of Traditional Hot Processing on Velvet Antler Based on 1H Nuclear Magnetic Resonance and Multivariate Statistical Analysis

    Jingfeng Li1, Hui Sun2, Xuefeng Bian1, Nanxi Zhang1, Yaping Wang3, Ying Zong4, Hui Zhang1★, Jiaming Sun1★★ Corresponding author

    1. 1Jilin Ginseng Academy, Changchun University of Traditional Chinese Medicine, China.
    2. 2Eastern District of Clinical Coordination Department, Hangzhou Simo Co., LTD, Hangzhou, P. R, China.
    3. 3College of Pharmacy, Changchun University of Chinese Medicine, China.
    4. 4College of Chinese Medicine Materials, Jilin Agricultural University, Changchun, China.

    CORRESPONDENCE

    Hui Zhang

    Jilin Ginseng Academy, Changchun University of Traditional Chinese Medicine, China.

    zhanghui_8080@163.com

    Received: 23-11-2018; Revised: 02-01-2019.

    Volume 15, Issue 63 · pp. 378–384 · PUBLISHED 16 May 2019 · DOI: 10.4103/pm.pm_594_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The aim of this study is to develop a method for exploring the mechanism of hot processing on velvet antler. Materials and Methods: In this study, the chemical compositions of fresh velvet antler (FVA) and hot processed velvet antler (HPVA) were compared based on the 1H nuclear magnetic resonance (1H NMR) and multivariate statistical analysis methods to explore the mechanism of hot processing on velvet antler. Results: It showed that hot processing increased phosphorylcholine, taurine, alanine, uridine, phenylalanine, uracil, tyrosine, accompanied by decreased bile acid, choline, lipid 2 and succinic acid in comparison to the FVA, which changed significantly in 52 common metabolites of FVA and HPVA. In addition, a clear separation between FVA and HPVA was obtained by using principal component analysis and 11 “chemical markers” were found by using orthogonal partial least squares discriminant analysis (OPLS‑DA) approaches. Particular attention was given to the “chemical markers” with potentially beneficial bioactivities. Conclusion: The study demonstrated that 1H NMR‑based chemometric approach could be a promising tool for investigation of the hot processing of velvet antler in a holistic way of TCM.

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      Li, J., Sun, H., Bian, X., Zhang, N., Wang, Y., Zong, Y., Zhang, H., & Sun, J. (2019). Research on Mechanism of Traditional Hot Processing on Velvet Antler Based on 1H Nuclear Magnetic Resonance and Multivariate Statistical Analysis. Pharmacognosy Magazine, 15(63), 378–384. https://doi.org/10.4103/pm.pm_594_18