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    Article

    Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol‑Induced Myocardial Oxidative Stress in Rats

    Anupama Sindhaghatta Kariyappa1★, Sowbhagya Ramachandregowda2, Santosh Anand2, Bhagyalakshmi Dundaiah1★ Corresponding author

    1. 1Mamatha Madhugiri Gopinath, Ravikiran Tekupalli Department of Biotechnology, Jnanabharathi Campus, Bangalore University, India.
    2. 2Ramaiah College of Arts Science and Commerce, Bengaluru, Karnataka, India.

    CORRESPONDENCE

    Anupama Sindhaghatta Kariyappa

    Mamatha Madhugiri Gopinath, Ravikiran Tekupalli Department of Biotechnology, Jnanabharathi Campus, Bangalore University, India.

    ravikiran@bub.ernet.in

    Received: 19-12-2018; Revised: 31-01-2019.

    Volume 15, Issue 64s · pp. S320–S327 · PUBLISHED 26 August 2019 · DOI: 10.4103/pm.pm_642_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region‑specific responses against isoproterenol (ISO)‑induced myocardial injury in male Wistar rats. Materials and Methods: Rats were orally supplemented with ellagic acid (50 mg/kg body weight [BW]), 4‑hydroxy isophthalic acid (30 mg/kg BW), and Dh extract (100 mg/kg BW) for 30 days, and they were subsequently administered (intraperitoneally) with ISO (150 mg/kg BW) for the last 2 days. Results: ISO‑treated rats showed a significant increase in serum lipid profile, markers of cardiac damage, and decreased antioxidant status. Supplemented groups showed improved lipid profile, reduced serum marker enzymes, and enhanced antioxidant status in ISO‑administered rats. Histopathological studies further confirmed the protective effect of Dh extract against ISO‑induced myocardial infarction (MI). Conclusion: Our results demonstrated that Dh extract and its compounds efficiently ameliorated ISO‑induced MI in rats.

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      Kariyappa, A. S., Ramachandregowda, S., Anand, S., & Dundaiah, B. (2019). Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol‑Induced Myocardial Oxidative Stress in Rats. Pharmacognosy Magazine, 15(64s), S320–S327. https://doi.org/10.4103/pm.pm_642_18