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    Article

    Morinda Citrifolia (Noni) Fruit Protects the Exocrine Pancreatic Dysfunction Against L‑Arginine Induced Acute Pancreatitis in Rats

    Veena Gadicherla1★, Siva Reddy Challa2, Mandava V. Basaveswara Rao3, Pavan Kumar Kunda4, Ramakrishna Prudhvi5★ Corresponding author

    1. 1Department of Pharmacology, Sri Indu Institute of Pharmacy, Ranga Reddy, India.
    2. 2Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India.
    3. 3Department of Chemistry, Faculty of Pharmaceutical Sciences, Krishna University, Krishna District, Andhra Pradesh, India.
    4. 4Department of Pharmaceutical Analysis, Shadan College of Pharmacy, Hyderabad, Telangana, India.
    5. 5Department of Pharmacy Practice, Dayananda Sagar College of Pharmacy, Bengaluru, Karnataka, India.

    CORRESPONDENCE

    Veena Gadicherla

    Department of Pharmacology, Sri Indu Institute of Pharmacy, Ranga Reddy, India.

    anugad@gmail.com

    Received: 28-12-2018; Revised: 24-01-2019; Accepted: 15-02-2019.

    Volume 15, Issue 64s · pp. S328–S334 · PUBLISHED 26 August 2019 · DOI: 10.4103/pm.pm_661_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic activities of <em>Crotalaria pallida</em> Aiton. Materials and Methods: The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Anti-inflammatory activity was evaluated by the inhibition of protein denaturation and membrane stabilization assays. Cytotoxicity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against human breast cancer (MCF-7) cell lines. Results: The methanolic extract of <em>C. pallida</em> showed significant antioxidant activity with IC50 values of 42.5 ± 1.2 µg/mL for DPPH and 128.4 ± 3.5 µg/mL for FRAP. The extract also exhibited potent anti-inflammatory activity in a dose-dependent manner. Furthermore, the extract demonstrated significant cytotoxic activity against MCF-7 cells with an IC50 value of 68.2 ± 2.4 µg/mL. Conclusion: The results suggest that <em>C. pallida</em> possesses significant pharmacological potential, which could be attributed to the presence of bioactive phytochemicals.

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      Gadicherla, V., Challa, S. R., Rao, M. V. B., Kunda, P. K., & Prudhvi, R. (2019). Morinda Citrifolia (Noni) Fruit Protects the Exocrine Pancreatic Dysfunction Against L‑Arginine Induced Acute Pancreatitis in Rats. Pharmacognosy Magazine, 15(64s), S328–S334. https://doi.org/10.4103/pm.pm_661_18