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    Anti‑Eczematic and Molecular Modeling of Anthraquinones Isolated from the Seeds of Asphodelus microcarpus Salzm. Viv. Growing in Egypt

    Abd El‑Salam I. Mohammed2, Arafa Musa2,3★, Marwa S. Abu‑Bakr4, Hatem S. Abbass2★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy (Boys), Al‑Azhar University.
    2. 2Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.
    3. 3Department of Pharmacognosy, Faculty of Pharmacy (Girls), Al‑Azhar University, Cairo, Egypt.

    CORRESPONDENCE

    Arafa Musa

    Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.

    arafa_1998@yahoo.de

    Received: 12-02-2019; Revised: 26-03-2019.

    Volume 15, Issue 65 · pp. 586–591 · PUBLISHED 19 September 2019 · DOI: 10.4103/pm.pm_67_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The objective of the study is to investigate the anti‑eczematic activity, acute toxicity, and molecular modeling of A. microcarpus seeds. Materials and Methods: Nuclear magnetic resonance, ultraviolet, and mass spectroscopy were applied for characterization of isolated metabolites; induction of eczema was conducted by 2% and 0.2% w/v dinitrochlorobenzene in acetone; eczema was treated with topical application of the different seed extracts in the form of ointments (1% w/w); Swiss albino mice (25–30 g) were used for the determination of LD50 and anti‑eczematic effect. Docking studies were performed by Molecular Operating Environment software. Results: A. microcarpus seed extract exhibited promising ant‑eczematic activity, six anthraquinones were isolated from chloroform portion and characterized as 10,7`‑bichrysophanol (1), asphodelin (2), chrysophanol‑8‑O‑methyl ether (3), chrysophanol (4), physcion (5), and emodin (6). Compounds 1, 3, and 5 exerted significant anti‑eczematic effect. Conclusion: Six known anthraquinone derivatives were isolated and characterized for the first time from the seeds of A. microcarpus. Chloroform fraction (1% w/w) showed significant anti‑eczematic effect compared to standard mometasone furoate (0.1 w/w). The docking study proved the anti‑eczematic activity of anthraquinone content by their affinity to the target human histamine H1 receptor.

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      Mohammed, A. E. I., Musa, A., Abu‑Bakr, M. S., & Abbass, H. S. (2019). Anti‑Eczematic and Molecular Modeling of Anthraquinones Isolated from the Seeds of Asphodelus microcarpus Salzm. Viv. Growing in Egypt. Pharmacognosy Magazine, 15(65), 586–591. https://doi.org/10.4103/pm.pm_67_19