Volume 15, Issue 65

Original Article

1. Article

   Tannic Acid‑Rich Porcupine Bezoars Induce Apoptosis and Cell Cycle Arrest in Human Colon Cancer Cells

   Peng-Nian Yew, Yau-Yan Lim, Wai-Leng Lee

   pp. 523–531 · DOI: 10.4103/pm.pm_620_18 · Published 19 September 2019

   Objectives: This study aimed to scientifically examine porcupine bezoars as a potential anticancer agent and to investigate their principal bioactive constituents. Materials and Methods: The porcupine bezoars were extrac…

2. Article

   In vitro UDP‑Glucuronosyltransferase and Cytochrome P450 Enzymes Activities of Clinacanthus nutans Leaf Juice and Aqueous Extract

   Gabriel Akyirem Akowuah, Jin Han Chin, Siew Wei Yeong, Suk Yen Quah, Mariam Ahmad

   pp. 532–537 · DOI: 10.4103/pm.pm_138_19 · Published 19 September 2019

   Aim: The objective of the present study was to evaluate the in vitro effect of aqueous extract of Clinacanthus nutans leaves and the juice on the activity of UDP‑glucuronosyltransferase (UGT), cytochrome P (CYP) 3A4, and…

3. Article

   Effect of Piper nigrum Ethanolic Extract on Human Breast Cancer

   Cell Growth, Cell Migration Benjaporn Buranrat, Supavadee Boontha

   pp. 538–546 · DOI: 10.4103/pm.pm_109_19 · Published 19 September 2019

   Objective: Our study purposes to illuminate the inhibition of PN effects on breast cancer cells growth and migration along with its mechanisms. Materials and Methods: The piperine in the young fruit of PN extract was det…

4. Article

   Optimization of Ultrasonic‑Assisted Extraction of Flavonoids and Anti‑oxidant Capacity from the Whole Plant of Andrographis echioides (L.) Nees by Response Surface Methodology and Chemical Composition Analysis

   Jayalakshmi Ramasamy, Ruckmani Kandasamy, Selvamani Palanisamy, Subramanian Nadesan

   pp. 547–556 · DOI: 10.4103/pm.pm_647_18 · Published 19 September 2019

   Objective: The objective of this study is to optimize the UAE conditions such as ethanol concentration (50%–100%), solvent‑to‑solid ratio (10–50 mL/g), and sonication time (20–60 min) for the extraction of flavonoids and…

5. Article

   Study on Pharmacokinetics and Tissues Distribution of Neomangiferin, Mangiferin, Timosaponin BII, Timosaponin BIII, and Timosaponin AIII after Oral Administration of Anemarrhenae Rhizoma Extract in Rats

   De Ji, Jin‑Chun Qiu, Xiao‑Nan Su, Yu‑Wen Qin, Min Hao, Lin Li, Tu‑Lin Lu, Xiao‑Kun Li, Cheng‑Xi Jiang

   pp. 557–567 · DOI: 10.4103/pm.pm_65_19 · Published 19 September 2019

   Objective: The main objective of the study is to establish an ultra‑high‑performance liquid chromatography‑tandem mass spectrometry (MS/MS) method to determine the concentrations of five bioactive constituents in rats’ p…

6. Article

   In vitro Antitoxoplasmal Activity of Some Medicinal Plants

   Ibrahim S. Al Nasr, Waleed S. Koko, Tariq A. Khan, Gamal E. Elghazali

   pp. 568–572 · DOI: 10.4103/pm.pm_646_18 · Published 19 September 2019

   Aim: In the present study, extracts from the leaves and fruit of Azadirachta indica A. Juss. collected from different areas, along with two other medicinal plants (Argemone mexicana L. and Xanthium brasilicum Vell.) with…

7. Article

   Juglone Induces Michigan Cancer Foundation‑7 Human Breast Cancer Cells Apoptosis through Bcl‑2‑Associated X protein/B‑cell lymphoma/leukemia‑2 Signal Way

   Qing Luo, Kang Hu, Fang Chen, Feng‑Jiao Gan, Yuan‑Xiu Leng, Xu‑Mei Chen, Su‑Hong Sun

   pp. 573–578 · DOI: 10.4103/pm.pm_604_18 · Published 19 September 2019

   Objective: The objective was to observe the effect of Juglone on the protein expression of caspase‑3, 9 in the apoptosis of Human Breast Cancer Cells (MCF7) and apoptosis‑related protein, Bcl‑2‑associated X protein (Bax)…

8. Article

   Effects of Atractylodes macrocephala Rhizoma on Isoproterenol‑Induced Myocardial Hypertrophy in Mice

   Ke‑Zhao Wei, Xiao‑Hua Cui, Jia‑Hua Feng, Ping‑An Yao, Jian‑Ping Gao

   pp. 579–585 · DOI: 10.4103/pm.pm_617_18 · Published 19 September 2019

   Objective: The purpose of this study was to assess the effects of AMR on attenuating myocardial hypertrophy induced by isoproterenol (ISO) in mice. Materials and Methods: Mice were randomly divided into normal control gr…

9. Article

   Anti‑Eczematic and Molecular Modeling of Anthraquinones Isolated from the Seeds of Asphodelus microcarpus Salzm. Viv. Growing in Egypt

   Abd El‑Salam I. Mohammed, Arafa Musa, Marwa S. Abu‑Bakr, Hatem S. Abbass

   pp. 586–591 · DOI: 10.4103/pm.pm_67_19 · Published 19 September 2019

   Objective: The objective of the study is to investigate the anti‑eczematic activity, acute toxicity, and molecular modeling of A. microcarpus seeds. Materials and Methods: Nuclear magnetic resonance, ultraviolet, and mas…

10. Article

    Antioxidant Flavonoids from Alhagi maurorum with Hepatoprotective Effect

    Muneera S.M. Al-Saleem, Lamya H. Al-Wahaibi, Wael M. Abdel-Mageed, Yaser G. Gouda, Hanaa M. Sayed

    pp. 592–599 · DOI: 10.4103/pm.pm_165_19 · Published 19 September 2019

    Objective: We have studied the antioxidant chemical components from A. maurorum to determine their in vitro antiproliferative and hepatoprotective activities. Materials and Methods: The alcoholic extract of A. maurorum r…

11. Article

    Rosmarinic Acid Inhibits Stem‑Like Breast Cancer through Hedgehog and Bcl‑2/Bax Signaling Pathways

    Hong Li, Yuefeng Zhang, Hsiao‑Huei Chen, En Huang, Hailin Zhuang, Dan Li, Feng Ni

    pp. 600–606 · DOI: 10.4103/pm.pm_22_19 · Published 19 September 2019

    Objective: This study aimed to detect whether RA could inhibit the proliferation and migration of BCSCs through hedgehog (Hh) signaling while promoting apoptosis via Bcl‑2/ Bax. Materials and Methods: BCSCs from the huma…

12. Article

    Development of a Species‑Specific Polymerase Chain Reaction‑Based Technology for Authentication of Asini Corii Colla and Taurus Corii Colla

    Liqun Chen, Zhaoqun Jiao, Yufei Chen, Pingtian Yu, Yang Zheng, Yaya Yang, Yuping Shen, Huan Yang

    pp. 607–612 · DOI: 10.4103/pm.pm_640_18 · Published 19 September 2019

    Objective: In this study, we aimed to develop a species‑specific polymerase chain reaction (PCR) approach to detect deoxyribonucleic acid (DNA) fragments of ACC and TCC for rapid authentication purpose. Materials and Met…

13. Article

    Antioxidative and Photocytotoxic Effects of Standardized Clinacanthus nutans and Strobilanthes crispus Extracts toward HepG2 Liver Cells

    Sheri‑Ann Tan, Shi Yun Lim, Chieu Shie Law, Chen Son Yue, Tze Ven Poh, Wan Zuhainis Saad, Saila Ismail, Khatijah Mohamad Yusoff, Chui Fung Loke

    pp. 613–620 · DOI: 10.4103/pm.pm_84_19 · Published 19 September 2019

    Objective: The present study aimed to determine the antioxidative and photocytotoxic effects of CME and SME toward liver cancer cells. Materials and Methods: Cell‑based (2′,7′‑dichlorodihydrofluorescein diacetate) and ch…

14. Article

    Structural Characterization and Immune Regulation of a New Heteropolysaccharide from Catathelasma imperiale (Fr.) Sing

    Lu Liu, Xiang Ding, Yiling Hou

    pp. 621–630 · DOI: 10.4103/pm.pm_673_18 · Published 19 September 2019

    Background: Polysaccharide has played the part of great role in pharmacology and physiology. Materials and Methods: In this study, the polysaccharides (CIS‑A) from Catathelasma imperiale (Fr.) Sing, were isolated and pur…

15. Article

    Cytotoxic Activity of Rauvolfia tetraphylla L. on Human Cervical Cancer (HeLa) Cells

    José Angel Santiago‑Cruz, Jesús Arrieta, Jazmín García‑Machorro, Daniel Arrieta‑Baez, María Elena Sánchez-Mendoza

    pp. 631–637 · DOI: 10.4103/pm.pm_106_19 · Published 19 September 2019

    Objective: The aim of the present study was to carry out a bioassay‑guided fractionation of Rauvolfia tetraphylla leaves to evaluate the activity on cervical cancer (HeLa) and normal cells. Materials and Methods: Of hexa…

16. Article

    Preventive Effect of Crude Polysaccharide Extract from Chinese Wolfberry against Hyperglycemia‑Induced Oxidative Stress and Inflammation in Streptozotocin‑Induced Diabetic Rats

    Junjie Li, Yong Zhang, Linshan Jiao, Opeyemi Joshua Olatunji, Bing He

    pp. 638–644 · DOI: 10.4103/pm.pm_164_19 · Published 19 September 2019

    Background: The protective effects of the crude polysaccharide extract Polysaccharide Lycium chinense (PLC) from the leaves of Lycium chinense (Chinese wolfberry) were evaluated in streptozotocin (STZ)‑induced diabetic r…

17. Article

    Influence of Flavonoids from Galium verum L. on the Activities of Cytochrome P450 Isozymes and Pharmacokinetic and Pharmacodynamic of Warfarin in Rats

    Mingyu Cui, Conghui Li, Xiaoyue Kong, Kai Zhang, Yuanyuan Liu, Qimeng Hu, Yingli Ma, Yanfeng Li, Tingting Chen

    pp. 645–651 · DOI: 10.4103/pm.pm_584_18 · Published 19 September 2019

    Background: Galium verum L., a traditional Chinese medicine, has been widely used in the folk in China. Preparations of G. verum L. were used to treat thromboembolic disease in clinic for many years and often combined wi…

18. Article

    Alisma orientalis (Sam.) Juzep Polysaccharide-Regulated Glucose-Lipid Metabolism in Experimental Rats and Cell Model of Diabetes Mellitus with Regulation of miR-126

    Zeng‑Kun Qian, Fan Cui, Yun‑Xi Ling, Wen‑Juan Zhu, Xiao‑Qin Li, Zheng Mao, Min‑Ting Li

    pp. 652–658 · DOI: 10.4103/pm.pm_441_18 · Published 19 September 2019

    Background: Alismatis rhizome (AR) is a popular traditional Chinese medicine, used for hyperlipidemia and diabetes in China for centuries; Alisma polysaccharides (AP) are the bioactive components in AR. This study invest…

19. Article

    In vitro and in vivo Anti-inflammatory Activity of the Methanolic Extract of the Leaves of Cissus quadrangularis

    Alaa El‑Din E. Abdel‑Hamid, Riham Salah El Dine, Jandirk Sendker, Soheir M. El Zalabani, Meselhy R. Meselhy, Elena Jimenez‑Negro, Ashraf B. Abdel‑Naim

    pp. 659–670 · DOI: 10.4103/pm.pm_547_18 · Published 19 September 2019

    Background: To assess the liver antifibrotic action of ethanolic extract of aerial parts of Solanum villosum Mill subsp. miniatum (Bernh. ex Willd.) (SVE) and correlate this activity with its high performance liquid chro…

20. Article

    Undulaterpene A: A New Triterpene Fatty Acid Ester from Pulicaria undulata

    Hossam Mohamed Abdallah, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Hani Z. Asfour, Maan T. Khayat

    pp. 671–674 · DOI: 10.4103/pm.pm_668_18 · Published 19 September 2019

    Objective: In this work, the chemical investigation of Pulicaria undulata aerial parts was performed. In addition, the cytotoxic activity of the isolated metabolites was estimated toward various cell lines. Materials and…

21. Article

    Bioactivity‑Guided Isolation of Cytotoxic and Antioxidant Phytochemicals from Four Cousinia Species from Stenocephala Bunge Section

    Leyla Pasayeva, Osman Üstün, Eren Demirpolat, Gökçe S. Karatoprak, Osman Tugay, Müberra Kosar

    pp. 682–692 · DOI: 10.4103/pm.pm_487_18 · Published 19 September 2019

    Objective: In this study, chemical compositions of four Cousinia species (Cousinia davisiana [CD], Cousinia foliosa, Cousinia ramosissima, and Cousinia stenocephala [CS]) were evaluated according to their cytotoxic and a…

22. Article

    Estrogenic Activity of Glycosides from Cistanche deserticola as an Estrogen Receptors Adjuvant in vitro

    Hui Song, Wen‑Lan Li, Xiang‑Ming Sun, Yang Hu, Jing‑Xin Ding, Yu‑Bin Ji, Jing‑Ya Wang

    pp. 693–697 · DOI: 10.4103/pm.pm_402_18 · Published 19 September 2019

    Objective: The objective of the study is to study estrogenic activity and the mechanism about estrogen receptors (ERs) of GCs. Materials and Methods: Cell proliferation was measured using the 3‑[4,5‑dimethyl‑2‑thiazolyl]…

23. Article

    Varthemia iphionoides and Pelargonium graveolens Extracts as a Treatment of Breast Cancer Implanted in Diabetic Mice

    Rana Y. Halees, Wamidh H. Talib, Reem A. Issa

    pp. 698–707 · DOI: 10.4103/pm.pm_18_19 · Published 19 September 2019

    Background: The relationship between cancer and type 2 diabetes is well documented. However, studies are very limited to test new therapies for both diseases in the same biological system. This study was conducted to tes…

24. Article

    Effects of Selected Moraceae Plants on Tyrosinase Enzyme and Melanin Content

    Sukanya Dej-adisai, Kedsaraporn Parndaeng, Chatchai Wattanapiromsakul, Wanlapa Nuankaew, Tong Ho Kang

    pp. 708–714 · DOI: 10.4103/pm.pm_43_19 · Published 19 September 2019

    Objective: Discovery of tyrosinase inhibitor from natural products by focusing on Moraceae plants. Materials and Methods: Forty‑eight Moraceae plant extracts were screened for antityrosinase and antibacterial activities;…

25. Article

    Antitumor Effects and Mechanism of Protein from Panax ginseng C. A. Meyer on Human Breast Cancer Cell Line MCF‑7

    Xilin Wan, Xin Jin, Yuhe Ren, Yang Xiu, Yu Li, Changbao Chen, Shuying Liu

    pp. 715–721 · DOI: 10.4103/pm.pm_151_19 · Published 19 September 2019

    Aims: Protein components were extracted from ginseng and antitumor activity in human breast cancer cell line MCF‑7 was investigated. Settings and Design: Five methods were applied to extract GP and the antitumor effects …

26. Article

    Systematic Estimation of Potential Risk Caused by the Replacement of Aconite’s Cultivar

    Yan Shen, Sun Xu, Wang Mengyan, Tang Yongbin, Chi Xu, Honeycutt Hailey, Tong Kai, Mou Lan, Chen Ji

    pp. 722–729 · DOI: 10.4103/pm.pm_136_19 · Published 19 September 2019

    Background: Aconite is a famous toxic medicinal plant in the world. But in China, the aconite cultivar, Qingchuan cultivar, which has been stably used for 2000 years, are being rapidly replaced by the Liangshan cultivar,…

27. Article

    A Green Method for Preparation of Curcuminoid‑rich Curcuma longa Extract and Evaluation of its Anticancer Activity

    Likit Lateh, Supreeya Yuenyongsawad, Haixia Chen, Pharkphoom Panichayupakaranant

    pp. 730–735 · DOI: 10.4103/pm.pm_162_19 · Published 19 September 2019

    Objective: To establish a green method for preparation of curcuminoid‑rich C. longa extracts (CRE) using microwave‑assisted extraction (MAE) together with a simple one‑step fractionation and to investigate the anticancer…

28. Article

    Chemical Composition from the Leaves of Lindera fragrans Oliv.

    He-Zhong Jiang, Tian Gan, Ya-Nan Li, Chun-Yan Du, Jun-Long Li, Jun-Ting Fan, Rui Tan

    pp. 736–739 · DOI: 10.4103/pm.pm_153_19 · Published 19 September 2019

    Objective: This paper reports the chemical investigation and biological evaluation of the L. fragrans. Materials and Methods: The petroleum ether and ethyl acetate soluble part of L. fragrans was isolated using chromatog…