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    Rasam (South Indian Spice Soup) - Attenuates the Mammary Tumor Induction Magnitude of 7,12‑Dimethylbenz[a] anthracene in Sprague–Dawley Rats

    Muthu Kumaradoss Mohanmarugaraja1★, Agilandeswari Devarajan2, Muthu Kumaradoss Kathiravan3★ Corresponding author

    1. 1Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Waghodia, Gujarat, India.
    2. 2Department of Pharmacy, Centre for Research and Development, PRIST University, India.
    3. 3Dr. APJ Kalam Research Laboratory, College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

    CORRESPONDENCE

    Muthu Kumaradoss Mohanmarugaraja

    Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Waghodia, Gujarat, India.

    mohan.raja19169@paruluniversity.ac.in

    Received: 16-04-2020; Revised: 05-05-2020; Accepted: 13-08-2020.

    Volume 16, Issue 5S · pp. S467–S473 · PUBLISHED 30 November 2020 · DOI: 10.4103/pm.pm_150_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: Breast cancer seems to be more common in the younger age group. Considering the deviation of the younger group from the traditional food habits as one of the many reasons of breast cancer incidence, rasam was investigated for its chemopreventive effect on mammary carcinoma. Materials and Methods: Rasam at 3 and 4 mL/kg dose was administered to female Spraque–Dawley rats for 30 days before 7,12‑dimethylbenz[a] anthracene (DMBA) induction of mammary carcinoma. Tamoxifen was used as the standard drug. Body weight, thiobarbituric acid reactive substances (TBARSs), phase I enzymes, hexokinase (HK), aldolase (AD), glucose 6‑phosphatase (G6P), fructose 1,6‑bisphosphatase (F16P), citric acid cycle (CAC) enzymes, histopathology, tumor weight, tumor latency, and tumor incidence were studied. Results: In all the studied parameters such as body weight, TBARS, phase I enzymes, HK, AD, G6P, F16P, and CAC enzymes, rasam‑pretreated groups showed better prevention than tamoxifen‑treated groups. Histochemical findings also clearly confirm the chemopreventive effect of rasam. Particularly at the dose of 4 mL/kg, rasam was efficient in reducing the percentage of incidence of tumor, number of tumor, and tumor weight. Conclusion: The present study reveals that rasam attenuates the mammary tumor induction magnitude of DMBA in female rats.

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      Mohanmarugaraja, M. K., Devarajan, A., & Kathiravan, M. K. (2020). Rasam (South Indian Spice Soup) - Attenuates the Mammary Tumor Induction Magnitude of 7,12‑Dimethylbenz[a] anthracene in Sprague–Dawley Rats. Pharmacognosy Magazine, 16(5S), S467–S473. https://doi.org/10.4103/pm.pm_150_20