Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    A Pentacyclic Triterpene from Lippia origanoides H.B.K and its Cytotoxic Activity

    Arvind Kumar2,3★, Elizabeth Quintero Rueda4, Jairo Rene Martínez3, Raquel Elvira Ocazionez4, Elena E. Stashenko3★★ Corresponding author

    1. 1Department of Chemistry, Hemwati Nandan Bahuguna Garhwal University, Srinagar, Uttarakhand, India.
    2. 2Centro de Investigación en Cromatografía y Espectrometría de Masas, CROM‑MASS, Universidad Industrial de Santander.
    3. 3Laboratorio de Arbovirus, Centro de Investigaciones en Enfermedades Tropicales (CINTROP), Universidad Industrial de Santander, Bucaramanga, Colombia.

    CORRESPONDENCE

    Arvind Kumar

    Centro de Investigación en Cromatografía y Espectrometría de Masas, CROM‑MASS, Universidad Industrial de Santander.

    arvindtomer81@gmail.com

    Received: 28-05-2020; Revised: 13-07-2020; Accepted: 11-08-2020.

    Volume 16, Issue 5S · pp. S513–S516 · PUBLISHED 30 November 2020 · DOI: 10.4103/pm.pm_218_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The current study was designed to investigate the phytochemicals from the steam‑distilled residual biomass of thymol‑ and carvacrol‑rich L. origanoides chemotypes and to evaluate their in vitro cytotoxic activity. Materials and Methods: Steam‑distilled aerial parts of L. origanoides chemotypes were extracted with SC‑CO2 to obtain a greenish‑yellow extract with a strong aromatic odor. The SC‑CO2 extract was subjected to column chromatography, and the isolate obtained was screened in vitro for cytotoxicity against human normal embryonic kidney 293, MRC‑5, THP‑1, and XP4PA cell lines, using the 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyl‑2H‑tetrazolium bromide (MTT) assay. Results: A pentacyclic triterpene, friedelan‑3‑one (1) was isolated for the first time from L. origanoides chemotypes. The structure of the isolate was elucidated with spectroscopic (ultraviolet, infrared, mass spectra, and nuclear magnetic resonance) techniques. The in vitro cytotoxic activity of the isolated compound was determined. The results showed no significant results against the selected cell lines using the MTT assay. Conclusion: The main significance of the present study was to develop promising routes to utilize the residual biomass for value‑addition. This is the first report of friedelan‑3‑one isolation from the genus Lippia.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Kumar, A., Rueda, E. Q., Martínez, J. R., Ocazionez, R. E., & Stashenko, E. E. (2020). A Pentacyclic Triterpene from Lippia origanoides H.B.K and its Cytotoxic Activity. Pharmacognosy Magazine, 16(5S), S513–S516. https://doi.org/10.4103/pm.pm_218_20