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    Article

    Effects of Artemisia judaica Essential Oil and Ethanolic Extract on Experimentally‑Induced Benign Prostatic Hyperplasia

    Bahaa Al‑Trad1★, Mazhar Al Zoubi2, Mu’ath Migdady1, Jamil Lahham1, Alaa AA Aljabali3, Malek Shehab1, Sahar Alomari1, Mahmoud A Al‑Qudah4, Janti Qar1, Riyadh Muhaidat1, Ahmad El‑Oqlah5, Murtaza M. Tambuwala6★ Corresponding author

    1. 1Department of Biological Sciences, Faculty of Science, Yarmouk University.
    2. 2SA, Northern Ireland, United Kingdom.
    3. 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University.
    4. 4Department of Chemistry, Faculty of Science, Yarmouk University, Irbid.
    5. 5Department of Biology, Jerash University, Jerash, Jordan.
    6. 6School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, BT52.

    CORRESPONDENCE

    Bahaa Al‑Trad

    Department of Biological Sciences, Faculty of Science, Yarmouk University.

    bahaa.tr@yu.edu.jo

    Received: 28-05-2020; Revised: 15-07-2020; Accepted: 11-08-2020.

    Volume 16, Issue 5S · pp. S561–S565 · PUBLISHED 30 November 2020 · DOI: 10.4103/pm.pm_216_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The present study aimed to address the effects of EO and EE on experimentally‑induced BPH in rats. Materials and Methods: Four experimental groups were assigned with six rats in each group, including the corn oil vehicle as a control. The three other groups were induced to develop BPH by testosterone injection. The BPH rats were randomized into the BPH‑untreated group, BPH‑EO treated group (200 mg/kg/subcutaneously) and BPH‑EE treated group (500 mg/kg/orally). Results: The prostate weight/body ratio and epithelial thickness showed a significant reduction in the EO and EE treated groups compared to the BPH untreated. In addition, mRNA expression levels of the proliferating marker (proliferating cell nuclear antigen), the angiogenesis marker (vascular endothelial growth factor‑A) and interleukin‑6; an inflammatory cytokine, were significantly down‑regulated in the BPH groups that were treated with EE or EO. Conclusion: Our results indicated that in experimentally‑induced BPH, EO and EE from A. judaica ameliorate BPH development by inhibiting prostatic cell proliferation, angiogenesis, and inflammation.

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      Al‑Trad, B., Zoubi, M. A., Migdady, M., Lahham, J., Aljabali, A. A., Shehab, M., Alomari, S., Al‑Qudah, M. A., Qar, J., Muhaidat, R., El‑Oqlah, A., & Tambuwala, M. M. (2020). Effects of Artemisia judaica Essential Oil and Ethanolic Extract on Experimentally‑Induced Benign Prostatic Hyperplasia. Pharmacognosy Magazine, 16(5S), S561–S565. https://doi.org/10.4103/pm.pm_216_20