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    Chronic Khat (Catha edulis) Chewing and Genotoxicity: The Role of Antioxidant Defense System and Oxidative Damage of DNA

    Ashraf A. Hassan2,3, Yahya Hasan Hobani2, Neji Mosbah2, Saif Elden Abdalla2, Mohammad Zaino2, Syam Mohan4, Maged El‑Setouhy5,6★★ Corresponding author

    1. 1Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jizan, Kingdom of Saudi Arabia.
    2. 2Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
    3. 3Substance Abuse and Toxicology Research Center, Jazan University.
    4. 4Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
    5. 5Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

    CORRESPONDENCE

    Maged El‑Setouhy

    Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

    maged.a.elsetouhy@gmail.com

    Received: 26-11-2019; Revised: 18-12-2019.

    Volume 16, Issue 68S · pp. S168–S173 · PUBLISHED 31 March 2020 · DOI: 10.4103/pm.pm_455_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: Mainly, the objective of the study was to assess the risk of genotoxicity caused due to oxidative stress that may result from khat chewing among chronic chewers from Jazan Province of Saudi Arabia. Materials and Methods: Hundred and twenty‑two adult males were recruited after signing informed consent. Ninety participants were chronic khat chewers (CKCs), while the control group consisted of 32 non-chewers of matched age and gender for the study group. A blood sample was collected from all participants and kept at 4°C until the time of assay. The activity of superoxide dismutase (SOD) and glutathione reductase (GR) were estimated in erythrocyte lysate as well as 8‑hydroxydeoxyguanosine (8‑OHdG) level in plasma. Results: There is a decreased SOD activity, which might be due to an increase in the endogenous production of reactive oxygen species resulted from the increase in lipid hydroperoxides. Furthermore, the significant elevation in GR activity was observed, reflecting the presence of highly toxic compounds. The 8‑OHdG levels were higher in khat chewers group in comparison to the control, but this increase was statistically insignificant. Conclusion: CKCs will be at considerable risk of oxidative stress as a result of a significant reduction in antioxidant enzymes. This would be a good reason for them to quit chewing khat for health benefits.

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      Hassan, A. A., Hobani, Y. H., Mosbah, N., Abdalla, S. E., Zaino, M., Mohan, S., & El‑Setouhy, M. (2020). Chronic Khat (Catha edulis) Chewing and Genotoxicity: The Role of Antioxidant Defense System and Oxidative Damage of DNA. Pharmacognosy Magazine, 16(68S), S168–S173. https://doi.org/10.4103/pm.pm_455_19