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    Pharmacokinetic and Pharmacodynamic Interactions of Tinospora cordifolia Aqueous Extract and Hypoglycemic Drugs in Streptozotocin‑Induced Diabetes in Rats

    Amisha Vora1★, Alice Varghese1, Yusuf Kachwala1, Ankit P Laddha2, Manju Bhaskar2, Jamal Akhtar3, Pawan Yadav3★ Corresponding author

    1. 1Departments of Pharmaceutical Chemistry, School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai, Maharashtra, India.
    2. 2Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai, Maharashtra, India.
    3. 3Central Council for Research in Unani Medicine, Ministry of AYUSH, Government of India, New Delhi, India.

    CORRESPONDENCE

    Amisha Vora

    Departments of Pharmaceutical Chemistry, School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai, Maharashtra, India.

    amisha.vora@nmims.edu

    Received: 25-06-2019; Revised: 06-09-2019.

    Volume 16, Issue 68S · pp. S47–S56 · PUBLISHED 31 March 2020 · DOI: 10.4103/pm.pm_272_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Aims: The aim of this study was to evaluate the potential pharmacokinetic (PK) and pharmacodynamic (PD) interactions of the aqueous extract of T. cordifolia (TCE) with metformin (MET), sitagliptin (SITA), and glibenclamide (GLI) in streptozotocin (STZ)‑induced diabetes in rats. Settings and Design: The aqueous TCE (400 mg/kg, p.o.) was co‑administered with MET (90 mg/kg, p. o.), SITA (10 mg/kg, p. o.), and GLI (1 mg/kg, p. o.) for 28 days in STZ‑induced diabetes in rats. Materials and Methods: The PK parameters of the three drugs were calculated using Phoenix WinNonlin®, and PD activity was determined by estimating fasting blood glucose, liver and kidney function tests, and lipid parameters. Further, histopathological examination of pancreatic cells and estimation of pancreatic antioxidant enzymes was carried out. Statistical Analysis Used: The pharmacokinetic parameters were estimated using pharmacokinetic program WinNonlin® version 3.0 (Pharmasight corporation, Mountain view, CA). The pharmacodynamic parameters were analysed using Graph Pad prism Version 6.00 applying one-way ANOVA followed by the Tukey–Kramer post test. Results: No significant PK interaction was observed between TCE and the three oral hypoglycemics. However, a significant improvement was observed in glycemic control and the conditions associated with diabetes mellitus. In addition, no incidences of hypoglycemia were observed. Conclusion: The co‑administration of TCE with MET, SITA, and GLI helped in better management of diabetes and associated comorbidities than their individual administrations. There were no significant PK interactions observed. Our findings provide insights into the safety and efficacy of the combination therapy of TCE with MET, SITA, and GLI in the management of diabetes and associated conditions.

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      Vora, A., Varghese, A., Kachwala, Y., Laddha, A. P., Bhaskar, M., Akhtar, J., & Yadav, P. (2020). Pharmacokinetic and Pharmacodynamic Interactions of Tinospora cordifolia Aqueous Extract and Hypoglycemic Drugs in Streptozotocin‑Induced Diabetes in Rats. Pharmacognosy Magazine, 16(68S), S47–S56. https://doi.org/10.4103/pm.pm_272_19