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    Amelioration of Doxorubicin‑Induced Cardiotoxicity by Oral Lyophilized Dunaliella salina Supplement in a Female Wistar Rat Model with Active Estrous Cycle and Surgical Menopause

    Sankaranarayanan Gomathinayagam1, Kodiveri Muthukaliannan Gothandam1★★ Corresponding author

    1. 1Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

    CORRESPONDENCE

    Kodiveri Muthukaliannan Gothandam

    Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

    gothandam@gmail.com

    Received: 29-02-2020; Revised: 28-03-2020; Accepted: 21-04-2020.

    Volume 16, Issue 70S · pp. S284–S289 · PUBLISHED 28 August 2020 · DOI: 10.4103/pm.pm_52_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> L. is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) stem. Materials and Methods: The anti-inflammatory activity was evaluated using the carrageenan-induced rat paw edema model. The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC) determination. Results: MECQ showed significant anti-inflammatory activity in a dose-dependent manner. In the antioxidant assays, MECQ exhibited potent radical scavenging activity and high phenolic content. Conclusion: The results suggest that <em>Cissus quadrangularis</em> possesses significant anti-inflammatory and antioxidant properties, which may contribute to its traditional medicinal uses.

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      Gomathinayagam, S., & Gothandam, K. M. (2020). Amelioration of Doxorubicin‑Induced Cardiotoxicity by Oral Lyophilized Dunaliella salina Supplement in a Female Wistar Rat Model with Active Estrous Cycle and Surgical Menopause. Pharmacognosy Magazine, 16(70S), S284–S289. https://doi.org/10.4103/pm.pm_52_20