Preclinical Study on Effects of Acalypha indica on Streptozotocin-induced Liver Damage in Diabetic Rats
Singamala Hari Prasad1, Ganjikunta Venkata Subbaiah1, Sahukari Ravi1, Boreddy Venu Gopal Reddy1★, Bhasha Shanmugam1★ Corresponding author
- 1Kesireddy Sathyavelu Reddy Department of Zoology, Division of Molecular Biology and Ethnopharmacology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
CORRESPONDENCE
Boreddy Venu Gopal Reddy
Kesireddy Sathyavelu Reddy Department of Zoology, Division of Molecular Biology and Ethnopharmacology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
Received: 27-06-2020; Revised: 12-08-2020; Accepted: 20-11-2020.
Volume 16, Issue 72 · pp. 722–729 · PUBLISHED 16 February 2021 · DOI: 10.4103/pm.pm_272_20
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ABSTRACT
Objective: In this study we investigated the quantifying and profiling of phenols in Acalypha indica polyphenol-rich fraction (PLF) and their therapeutic potential on hepatic tissue damage in streptozotocin (STZ) induced diabetic rats. Materials and Methods: In this study,PLF was subjected the gas chromatography–mass spectrometry and High Resolution Liquid Chromatograph Mass Spectrometer HR-LC-MS and evaluate the liver biomarkers includes aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin content, lipid profiles like low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TGs), and high-density lipoprotein (HDL), insulin and body weights in diabetic, PLF, and glibenclamide-treated diabetic and normal rats. Results: The result showed that PLF was significantly decreased the blood glucose levels, liver biomarkers such as AST, ALT, ALP, bilirubin content, lipid profiles like LDL, TC, and TGs and decreased the tissue damage in diabetic rats. Subsequently, insulin, body weight, and HDL levels were increased in diabetic rats. Subsequently, insulin, body weight, and HDL levels were increased. Conclusion: We concluded that Ai (Acalypha indica ) leaves have a rich number of polyphenolic compounds and those were may be protected from STZ-induced toxicity in liver of diabetic rats. Further research is necessary for this area to isolate bioactive polyphenolic compounds from Ai leaves and to be validated against STZ- intoxicated liver damage with assessing mechanism of action.
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Prasad, S. H., Subbaiah, G. V., Ravi, S., Reddy, B. V. G., & Shanmugam, B. (2021). Preclinical Study on Effects of Acalypha indica on Streptozotocin-induced Liver Damage in Diabetic Rats. Pharmacognosy Magazine, 16(72), 722–729. https://doi.org/10.4103/pm.pm_272_20