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    Article

    Isolation of New Diterpene from Methanolic Extract of Capsicum annuum Linn. Fruits

    Neeraj Kumar Fuloria1, Shivkanya Fuloria1, Vijay Kumar Sharma2, Mohammed Ali3, Amit Singh4, Pradeep Kumar Sharma2★★ Corresponding author

    1. 1Faculty of Pharmacy, AIMST University, Bedong, Kedah, Malaysia.
    2. 2Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, Uttar Pradesh.
    3. 3School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi.
    4. 4Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.

    CORRESPONDENCE

    Pradeep Kumar Sharma

    Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar, Ghaziabad, Uttar Pradesh.

    pradeepbsr17@gmail.com

    Received: 10-06-2020; Revised: 06-07-2020; Accepted: 15-09-2020.

    Volume 16, Issue 72 · pp. 730–732 · PUBLISHED 16 February 2021 · DOI: 10.4103/pm.pm_250_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The present investigation was intended to explore the CAFME for the presence of any new phytoisolate. Materials and Methods: The study involved the preparation of CAFME, followed by critical isolation through normal phase silica‑gel based column chromatography using various combinations of petroleum ether and chloroform. The phytoisolate was characterized using ultraviolet, Fourier transformed infrared, Nuclear magnetic resonance (1H, 13C, Distortion less enhancement by polarization transfer and correlation spectroscopy), and mass spectrometry. Results: The chromatographic critical isolation and spectrometric experiment over CAFME offered a new phytoisolate characterized as 3,11,15‑trimethyl‑14 β‑hydroxy‑n‑hexadeca‑7‑en‑4,18‑ol ide (CA‑1). Conclusion: The present study concludes the isolation of a new diterpene 3,11,15‑trimethyl‑14 β‑hydroxy‑n‑hexadeca‑7‑en‑4,18‑olide (CA‑1) for the first time in CAFME. The present study also recommends that in future this new phytoisolate should be further standardized and explored for its therapeutic properties.

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      Fuloria, N. K., Fuloria, S., Sharma, V. K., Ali, M., Singh, A., & Sharma, P. K. (2021). Isolation of New Diterpene from Methanolic Extract of Capsicum annuum Linn. Fruits. Pharmacognosy Magazine, 16(72), 730–732. https://doi.org/10.4103/pm.pm_250_20