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    Article

    Therapeutic Targets and Biological Mechanisms of Curcumol on Atherosclerosis: A Study Based on Network Pharmacology Approach and Biological Studies

    Baolian Ma2,3,4, Shilin Yang3,4, Junmao Li4, Zhiqi Wen4, Hui Ouyang4, Wugang Zhang4, Yulin Feng4★, Mingzhen He4★★ Corresponding author

    1. 1Department of Pharmacy, Changzhi Medical College, Changzhi, China.
    2. 2School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
    3. 3The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang, China.

    CORRESPONDENCE

    Yulin Feng

    fengyulin2003@126.com

    Received: 09-08-2020; Revised: 21-09-2020; Accepted: 23-02-2021.

    Volume 17, Issue 74 · pp. 216–222 · PUBLISHED 12 July 2021 · DOI: 10.4103/pm.pm_336_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: Curcumol extracted from the traditional Chinese medicine (TCM) E‑Zhu (Curcumae Rhizoma), is one of the chief bioactive ingredients of Curcuma oil (a marketed drug in China). Materials and Methods: To classify core targets and discover the main biological mechanisms of curcumol against atherosclerosis, a network pharmacology tactic was commenced for data mining, and biological experiments were engaged for validation. Results: Absorption, metabolism and excretion screening using TCM Systems Pharmacology Database and Analysis Platform server, target forecast using public databases, protein‑protein interaction network analysis using the STRING database and Kyoto Encyclopedia of Genes and Genomes pathway analysis were engaged to examine the potential mechanisms of curcumol on atherosclerosis. On the basis of data mining, 10 core targets and related pathways were recognized. Furthermore, the key target signaling pathways, interleukin 6 (IL‑6), IL‑10, and JAK2/STAT3, were authenticated using biological studies. Conclusion: Curcumol could improve atherosclerosis by reducing the formation of foam cells; the mechanism of action was ascribed to the downregulation of IL‑6 expression, upregulation of IL‑10 expression and inhibition of the JAK‑STAT pathway. Therefore, this study will be a basis for further study of the biological roles of curcumol on atherosclerosis.

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      Ma, B., Yang, S., Li, J., Wen, Z., Ouyang, H., Zhang, W., Feng, Y., & He, M. (2021). Therapeutic Targets and Biological Mechanisms of Curcumol on Atherosclerosis: A Study Based on Network Pharmacology Approach and Biological Studies. Pharmacognosy Magazine, 17(74), 216–222. https://doi.org/10.4103/pm.pm_336_20