Volume 17, Issue 74

Original Article

1. Article

   Characterization of Secondary Metabolites in Different Parts of Ocimum gratissimum L. by in vitro Antioxidant Activity and High‑performance Liquid Chromatography–Diode‑array Detector Analysis

   Sharmistha Ganguly, Jyoti Kumar, Tapan Seal

   pp. 209–215 · DOI: 10.4103/pm.pm_550_20 · Published 12 July 2021

   Objectives: The present study focused on evaluation of the total phenolic content, total flavonoid content, and reducing and antioxidizing activities from methanolic extract of different plant parts, namely leaves, stem,…

2. Article

   Therapeutic Targets and Biological Mechanisms of Curcumol on Atherosclerosis: A Study Based on Network Pharmacology Approach and Biological Studies

   Baolian Ma, Shilin Yang, Junmao Li, Zhiqi Wen, Hui Ouyang, Wugang Zhang, Yulin Feng, Mingzhen He

   pp. 216–222 · DOI: 10.4103/pm.pm_336_20 · Published 12 July 2021

   Objective: Curcumol extracted from the traditional Chinese medicine (TCM) E‑Zhu (Curcumae Rhizoma), is one of the chief bioactive ingredients of Curcuma oil (a marketed drug in China). Materials and Methods: To classify …

3. Article

   Rapid Qualitative and Quantitative Analysis of Volatile Components and Quality Identification of Amomi Fructus Based on Bionic Olfactory System

   Huaying Zhou, Zhong Li, Dehan Luo, Hamid Gholamhosseini, Bin Han, Hexian Wang

   pp. 223–230 · DOI: 10.4103/pm.pm_187_20 · Published 12 July 2021

   Background: Amomi fructus (AF) (a dried fruit of Amomum villosum Lour.) has been used in the treatment of digestive diseases such as abdominal pain and dysentery and in the prevention of abortion. The active ingredient o…

4. Article

   Costunolide Attenuates Oxygen‑glucose Deprivation/ Reoxygenation‑Induced Apoptosis in Mouse Brain Slice through Inhibiting Caspase Expression

   Huixia Ma, Yafei Zhu, Zhengjun Zhang, Xinhui Zhang, Qipeng Zhao

   pp. 231–235 · DOI: 10.4103/pm.pm_360_20 · Published 12 July 2021

   Background: Costunolide (Co) has anti‑tumor, anti‑inflammation, and anti‑ulcer effects, it has the budding effect of anti‑apoptosis. This study was intended to explicate its inhibitory effect on caspase in a mice brain s…

5. Article

   Identification of Chemical Constituents and Inhibitory Effect of Ficus deltoidea Fraction against Lipopolysaccharide‑Induced Nuclear Factor‑Kappa B Inflammatory Pathway in Murine Macrophage 264.7 Cells

   Rameshkumar Santhanam, Gothai Sivapragasam, Thiruventhan Karunakaran, Katyakyini Muniandy, Senthilkumar Palani Kandasamy, Arulselvan Palanisamy

   pp. 236–243 · DOI: 10.4103/pm.pm_433_20 · Published 12 July 2021

   Objectives: The aim is to determine the anti‑inflammatory mechanism of various solvent fractions of F. deltoidea methanol extract against Lipopolysaccharide (LPS)‑induced nuclear factor‑kappa B (NF‑κB) inflammatory pathw…

6. Article

   Ferruginol‑induced Apoptosis in Human Colon Cancer Cells (HCT‑116) through the Mitochondria‑Mediated Apoptotic Pathway

   Hua-Long Lin, Pei-Rui Chen, Chun-Chun Mao, Wei-E Zheng, Jia-Qi Wang

   pp. 244–249 · DOI: 10.4103/pm.pm_53_20 · Published 12 July 2021

   Objectives: In this current investigation, we observed the anticancer and proapoptotic potentials of ferruginol (FGL) in human colon cancer (HCT‑116) cells. Materials and Methods: We recognized that the potentials of FGL…

7. Article

   Citral Promotes the Cell Proliferation, Differentiation, and Calcium Mineralization in Human Osteoblast‑like MG‑63 Cells

   Hong Mu, Ying Pang, Lili Liu, Fengshan Li, Jianqi Wang

   pp. 250–255 · DOI: 10.4103/pm.pm_242_20 · Published 12 July 2021

   Background: Osteoporosis tends to be the major consequence of fractures in women above the age of 50 years and men are prone above the age of 65 years. The structure of bone is severely deteriorated by the reduction in b…

8. Article

   The Gastroprotective Effect of Alpinia officinarum Extract on Indomethacin‑Induced Topical Injuries in RGM‑1 Cells: Involvement of H+/K+‑ATPase‑ and Mitochondrial‑Mediated Apoptosis

   Li Li, Jingwen Gong, Hailong Li, Mingyan Zhou, Yinfeng Tan, Junqing Zhang

   pp. 256–262 · DOI: 10.4103/pm.pm_65_20 · Published 12 July 2021

   Background: Topical effects are essential mechanisms of nonsteroidal anti‑inflammatory drugs (NSAIDs)‑induced gastric damage. Our previous study showed that the extract of Alpinia officinarum (AOE) may have some protecti…

9. Article

   In silico Studies on the Therapeutic Potential of Novel Marker Compounds Isolated from Chemically Modified Bioactive Fraction from Curcuma longa (Non-carbonyl Curcuma longa)

   Arshi Naqvi, Reem A. K. Al‑Harbi, Samah Ali, Richa Malasoni, Swati Gupta, Anil Kumar Dwivedi

   pp. 263–267 · DOI: 10.4103/pm.pm_317_20 · Published 12 July 2021

   Objectives: In the present study, novel marker compounds (A and B) have been successfully isolated from NCCL and their various in silico traits and interactions were studied. Materials and Methods: Marker compounds A and…

10. Article

    Attenuation of Kirenol InflammationInduced by Ischemic/ Reperfusion Cerebral Infarction Stroke via TLR4/ NLRP3 Signaling Pathway: An in vivo Approach

    Debo Yun, Yujiao Yang, Bin Shang, Heng Dong, Bo Luo, Tahani Awad Alahmadi, Qing Luo

    pp. 268–274 · DOI: 10.4103/pm.pm_261_20 · Published 12 July 2021

    Objective: In this study, we examined the therapeutic role of kirenol against I/R‑induced neuronal damage by inhibiting inflammation in Sprague‑Dawley (SD) rats. Materials and Methods: I/R was induced in SD rats and subs…

11. Article

    Resveratrol Exerts Anti‑Inflammatory Effect in Lipopolysaccharide‑Induced Lung Inflammation via Downregulation of Antioxidant and Inflammatory Mediators

    Xinxin Liang, Jian Shen, Xueming Duan, Rongbing Zhou, Peng Liu, Xiaoming Chi

    pp. 275–281 · DOI: 10.4103/pm.pm_41_20 · Published 12 July 2021

    Objectives: In this study, the chemoprotective effect of resveratrol and its of mechanism of action against the Lipopolysaccharide (LPS)-induced lung inflammation was investigated. Materials and Methods: In this in vitro…

12. Article

    Effects of Ginsenoside Rb1 on Serum Brain Natriuretic Peptide Level and Caspase‑3 Protein Expression in Cardiomyocytes of Rats with Chronic Heart Failure

    Yaoyao Wang, Yujiang Chen, Mao Yang, Chunlin Chen

    pp. 282–287 · DOI: 10.4103/pm.pm_561_19 · Published 12 July 2021

    Aim: The aim of this study was to evaluate the effects of ginsenoside Rb1 on the level of brain natriuretic peptide (BNP) in serum and the expression of caspase‑3 protein in the cardiomyocytes of CHF rats. Subjects and M…

13. Article

    Oroxylum indicum Kurz (L.) Seed Extract Exerts Antioxidant and Anti‑Inflammatory Effects on Lipopolysaccharide‑Stimulated BV2 Microglial Cells

    Nootchanat Mairuae, Poonlarp Cheepsunthorn, Benjaporn Buranrat, Supataechasit Yannasithinon

    pp. 288–292 · DOI: 10.4103/pm.pm_393_20 · Published 12 July 2021

    Objectives: The present study aimed to investigate the anti‑inflammatory and antioxidant role of OIS extract in a neuroinflammatory model of lipopolysaccharide (LPS)‑stimulated microglia cells. Materials and Methods: BV2…

14. Article

    Metabolomics Study on the Therapeutic Mechanism of Schisandra chinensis Polysaccharides on Concanavalin A‑Induced Immunological Liver Injury in Mice

    Lihua Chen, Yingying Shan, Chunmei Wang, He Li, Jianguang Chen, Jinghui Sun

    pp. 293–301 · DOI: 10.4103/pm.pm_255_20 · Published 12 July 2021

    Aim: In this study, we aimed to evaluate the hepatoprotective mechanism of SCP in immunological liver injury. Subjects and Methods: In this study, we performed rapid‑resolution liquid chromatography coupled with quadrupl…

15. Article

    Antitrypanosomal and Antileishmanial Effects of the Hydroalcoholic Extract of Croton cajucara Benth and its 19‑nor‑Clerodane Chromatographic Fractions

    Gerson S. Lima, Gerzia C. Machado, Maria A. M. Maciel, Aurea Echevarria

    pp. 302–306 · DOI: 10.4103/pm.pm_345_20 · Published 12 July 2021

    Objectives: The objective of the study is to evaluate the stem bark hydroalcoholic extract (CC‑EHA) of C. cajucara and their clerodane‑type diterpene fractions (F1‑7, F25‑27, and F28) on promastigotes and axenic amastigo…

16. Article

    Carthami flos Induces Apoptosis by Activating Caspases and Regulating Mitogen‑Activated Protein Kinase and Reactive Oxygen Species Signaling Pathways in AGS Human Gastric Cancer Cells

    Song Ee Han, Min Ji Kwon, Jeong Nam Kim, Eun Yeong Lim, Yun Tai Kim, Byung Joo Kim

    pp. 307–314 · DOI: 10.4103/pm.pm_127_20 · Published 12 July 2021

    Objectives: The mechanisms of cell death induction by CF were investigated in AGS human gastric adenocarcinoma cells. Materials and Methods: Cell viability assay, cell cycle analysis, caspase activity assay, western blot…

17. Article

    Protective Effects of Elaeagnus angustifolia L. Leaves against H2O2-Induced Oxidative Damage in Rat Schwann Cells (RSC-96) through Regulation of PI3K/Akt Signaling Pathway

    Yun Sun, Hui Yao, Xin Zhang, Xiao-Xuan Yuan, Han-Lin Xu

    pp. 315–320 · DOI: 10.4103/pm.pm_275_20 · Published 12 July 2021

    Objective: In this study, our primary goal was to understand the mechanism of action of Elaeagnus angustifolia L. leaves (EALs) in protecting Rat Schwann cells (RSC-96) against H2O2-induced oxidative stress. Materials an…

18. Article

    Resveratrol Attenuates Inflammation by Regulating Macrophage Polarization via Inhibition of Toll‑Like Receptor 4/MyD88 Signaling Pathway

    Yue Fan, Si-Lin Huang, Hong Li, Yu-Lin Cui, Dong-Yan Li

    pp. 321–326 · DOI: 10.4103/pm.pm_312_20 · Published 12 July 2021

    Objectives: In this study, we aimed to determine whether RES attenuates inflammation by regulating macrophage polarization through inhibition of toll‑like receptor 4 (TLR4)/ MyD88 signaling. Materials and Methods: We mea…

19. Article

    Paeoniflorin Prevents Depression Like Behavior in Rats by Suppressing Mitophagy Mediated NOD like Receptor Protein 3 Inflammasome Signaling

    Meng Wang, Shuguang Yan, Jingyi Kong, Yongxue Zhou, Pei Xie

    pp. 327–333 · DOI: 10.4103/pm.pm_85_20 · Published 12 July 2021

    Background: The pathogenesis of depression is related to the NOD‑like receptor protein 3 (NLRP3) inflammasome activation and low level of mitophagy. In traditional Chinese medicine, Paeonia lactiflora Pall is a common he…

20. Article

    Lappaconitine Hydrochloride Induces Apoptosis and S Phase Cell Cycle Arrest through MAPK Signaling Pathway in Human Liver Cancer HepG2 Cells

    Na Song, Junyi Ma, Xuemei Zhang, Danni Qu, Ling Hui, Chunyan Sang, Haining Li

    pp. 334–341 · DOI: 10.4103/pm.pm_251_20 · Published 12 July 2021

    Objectives: The objective of this study was to examine the antitumor effect and primary mechanisms of LH on cell proliferation, cell cycle, and apoptosis in HepG2 cells. Materials and Methods: The cell viability and prol…

21. Article

    Content Determination of Functional Composition and Antioxidant Activity from Six Purple Plants

    Fang-Rong Cheng, Hong-Xin Cui, Ji-Li Fang, Ke Yuan, Song-Heng Jin, Xiang-Tao Zhu, Yong Xu

    pp. 342–347 · DOI: 10.4103/pm.pm_203_20 · Published 12 July 2021

    Background: Nowadays, many purple vegetables are available in the market. These vegetables have rich content of anthocyanins, which gives them their characteristic purple color. A high intake of anthocyanin‑rich vegetabl…

22. Article

    An Analytic Hierarchy Process Multi‑criteria Quantitative Evaluation Model of Cinnamon Decoction Pieces

    Zi-Ye Yang, Xin-Jie Wang, Yao Zhang, Hui Gao, Hui-Nan Wang, Gui-Mei Zhang, Pei-Hua Wang, Yue-Xin Cui, Meng-Yu Chen, Zhan Chen, Ying-Zi Wang

    pp. 348–354 · DOI: 10.4103/pm.pm_306_20 · Published 12 July 2021

    Objectives: The objective was to introduce the analytic hierarchy process (AHP) to estimate widely and compare the quality of cinnamon decoction pieces. Materials and Methods: The chemical, morphological, and biological …

23. Article

    Chemical Composition, Antimycobacterial and Antiinflammatory Activities of Iridoids and Triterpene from Psychotria suterella (Rubiaceae)

    Almir Ribeiro De Carvalho Junior, Rafaela Oliveira Ferreira, Michel de Souza Passos, Milena Gonçalves Curcino Vieira, Lorena de Lima Glória das Virgens, Sanderson Dias Calixto, Thatiana Lopes Biá Ventura, Elena Lassounskaia, Mario Geraldo de Carvalho, Raimundo Braz‑Filho, Ivo José Curcino Vieira

    pp. 355–359 · DOI: 10.4103/pm.pm_93_20 · Published 12 July 2021

    Objectives: The objective was to study on the chemical constituents of the leaves of plant and evaluate the anti‑TB and anti‑inflammatory activity. Materials and Methods: Solvent extraction, partition, and column chromat…

24. Article

    Isolation and Anticancer Effect of Brucine in Human Colon Adenocarcinoma Cells HT‑29

    Zhenyu Feng, Shuang Meng, Xiaorong Zhou, Xiaojuan Ma, Zhengbao Zhao, Jianping Zhao

    pp. 367–372 · DOI: 10.4103/pm.pm_95_20 · Published 12 July 2021

    Objectives: The objective of the study is to isolate and examine the effect of brucine on human colon adenocarcinoma cell line HT‑29. Materials and Methods: Crude brucine was acquired by the extraction of Nux vomica with…

25. Article

    Efficacy and Safety on Moringa oleifera on Blood Glucose and Lipid profile: A Meta‑analysis

    Wiraphol Phimarn, Bunleu Sungthong, Kittisak Wichaiyo

    pp. 373–378 · DOI: 10.4103/pm.pm_49_20 · Published 12 July 2021

    Objectives: The main objective of this study was to assess the effects of MO consumption on blood glucose level and lipid profile in randomized controlled trial (RCTs) and non‑RCTs. Materials and Methods: A comprehensive…

26. Article

    Potential Effect of Astragaloside IV on the Lipopolysaccharide Induced Inflammation via the Inactivation of NF‑κB Signaling Pathway

    Xuebo Yan, Tong Wang, Lei Fang, Jiong Wang

    pp. 379–386 · DOI: 10.4103/pm.pm_267_20 · Published 12 July 2021

    Background: The host treats lipopolysaccharides (LPS) as a sign of microbial invasion by pathogenic Gram‑negative bacteria. In lungs, LPS activates a cascade of inflammatory reactions leading to inflammation. Previous in…

27. Article

    Colocasia esculenta L. Schott Corm Mucilage: A Selective COX‑2 Inhibitor for Treatment of Irritable Bowel Syndrome

    Nesrin M. Fayek, Samar M. Mouneir, Azza Ramy Abdel Monem, Samia M. Abdelwahab, Nebal D. Eltanbouly

    pp. 387–390 · DOI: 10.4103/pm.pm_488_20 · Published 12 July 2021

    Background: Therapeutic strategies used for the treatment of irritable bowel syndrome having many limitations due to their side effects; this necessitates searching for new substitutes with similar therapeutic results an…

28. Article

    Antiarthritic Activity of Asiaticoside against the Freund’s Complete Adjuvant‑Induced Rheumatoid Arthritis in Experimental Wistar Rats

    Xiaohui Zhou, Jiasong Zhao, Zheng Zhang, Chunmei Geng, Jinwei Ying

    pp. 391–398 · DOI: 10.4103/pm.pm_247_19 · Published 12 July 2021

    Background: Rheumatoid synovial inflammation occurs at the synovial joint, which is activated by the articular system and mediated by the immune cells. In the case of untreated rheumatoid arthritis, the inflammation may …