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    Chemical Composition, Antimycobacterial and Antiinflammatory Activities of Iridoids and Triterpene from Psychotria suterella (Rubiaceae)

    Almir Ribeiro De Carvalho Junior1★, Rafaela Oliveira Ferreira2, Michel de Souza Passos3, Milena Gonçalves Curcino Vieira4, Lorena de Lima Glória das Virgens5, Sanderson Dias Calixto5, Thatiana Lopes Biá Ventura6, Elena Lassounskaia5, Mario Geraldo de Carvalho7, Raimundo Braz‑Filho3,7, Ivo José Curcino Vieira3★ Corresponding author

    1. 1Instituto Federal de Santa Catarina, Câmpus Criciúma, Criciúma, SC, Brazil.
    2. 2Centro de Ciências Exatas e Tecnológicas, Universidade Federal do Recôncavo da Bahia, Cruz das Almas, BA, Brazil.
    3. 3Laboratório de Ciências Químicas, Centro de Ciência e Tecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.
    4. 4Instituto Federal Fluminense, Câmpus Centro, Campos dos Goytacazes, Brazil.
    5. 5Laboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.
    6. 6Laboratório de Produtos Bioativos, Curso de Farmácia, Universidade Federal do Rio de Janeiro, Macaé, Brazil.
    7. 7Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.

    CORRESPONDENCE

    Almir Ribeiro De Carvalho Junior

    Instituto Federal de Santa Catarina, Câmpus Criciúma, Criciúma, SC, Brazil.

    almir.ribeiro@ifsc.edu.br

    Received: 13-04-2020; Revised: 29-05-2020; Accepted: 09-03-2021.

    Volume 17, Issue 74 · pp. 355–359 · PUBLISHED 12 July 2021 · DOI: 10.4103/pm.pm_93_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The objective was to study on the chemical constituents of the leaves of plant and evaluate the anti‑TB and anti‑inflammatory activity. Materials and Methods: Solvent extraction, partition, and column chromatography were used to separate the compounds. The structures of these compounds were determined by extensive one dimensional‑and two dimensional‑Nuclear Magnetic Resonance, infrared and mass spectrometry spectroscopic analyses. Some compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis and their ability to inhibit nitric oxide (NO) production by lipopolysaccharide‑stimulated macrophages. Results: This study led to the isolation and characterization of a new iridoid, named epi‑geniposidic acid (1), together with nine known compounds: geniposidic acid (2), 3‑O‑acethyloleanolic acid (3), pomolic acid (4), spinolic acid (5), maslinic acid (6), tormentic acid (7), methyl oleanolate (8), lyalosidic acid (9), and strictosidinic acid (10). Triterpene 3‑O‑acethyloleanolic acid (3) was found to display antimycobacterial activity against M. tuberculosis H37Rv strain and hypervirulent strain (minimum inhibitory concentration 6.7 ± 0.1 and 89.1 ± 1.3 µg/ mL, respectively). Epi‑geniposidic acid (1), geniposidic acid (2), and 3‑O‑acethyloleanolic acid (3) showed promising inhibitory activities against NO production (IC50 range 4.12–5.12 μg/mL). The iridoid mixture showed no cytotoxicity against RAW 264.7 macrophages up to a concentration of 100 µg/mL. Conclusion: P. suterella presents relevant biological properties and should be considered for further in vivo studies using a pulmonary TB model.

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      Junior, A. R. D. C., Ferreira, R. O., Passos, M. D. S., Vieira, M. G. C., Virgens, L. D. L. G. D., Calixto, S. D., Ventura, T. L. B., Lassounskaia, E., Carvalho, M. G. D., Braz‑Filho, R., & Vieira, I. J. C. (2021). Chemical Composition, Antimycobacterial and Antiinflammatory Activities of Iridoids and Triterpene from Psychotria suterella (Rubiaceae). Pharmacognosy Magazine, 17(74), 355–359. https://doi.org/10.4103/pm.pm_93_20