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    Article

    Deguelin Treatment Attenuated the Lipopolysaccharides‑Provoked Inflammation in Murine Macrophage and Dextran Sulfate Sodium‑Inflamed Acute Colitis in Mice through Suppression of Inflammatory Markers

    Furong Wei1★, Xirong Lu2★, Xiaomin Guo3, Penglin Liu4, Aiting Di4, Arunachalam Chinnathambi5, Tahani Awad Alahmadi6, Sulaiman Ali Alharbi5, Lize Zhang4★★ Corresponding author

    1. 1Department of Gastroenterology, Central Hospital of Haining, Haining, Zhejiang, 314408.
    2. 2Department of Spleen, Stomach and Gallbladder, Traditional Chinese Medical Hospital of Kunshan, Kunshan, Jiangsu, 215300.
    3. 3Chuxiong Medical College, Chuxiong, Yun’nan, 675000.
    4. 4Department of Anorectal, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China.
    5. 5Department of Botany and Microbiology, College of Science, King Saud University, Riyadh -11451.
    6. 6Department of Pediatrics, College of Medicine, King Saud University, [Medical City], King Khalid University Hospital, Riyadh -11461, Saudi Arabia.

    CORRESPONDENCE

    Furong Wei

    Department of Gastroenterology, Central Hospital of Haining, Haining, Zhejiang, 314408.

    drzhanglize@sina.com

    Received: 31-12-2019; Revised: 17-02-2020; Accepted: 16-02-2021.

    Volume 17, Issue 75 · pp. 451–459 · PUBLISHED 11 November 2021 · DOI: 10.4103/pm.pm_570_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: In this investigation, we anticipated to examine the curative usefulness of deguelin, a natural herbal rotenoid against the lipopolysaccharide (LPS)‑provoked inflammatory responses in murine macrophages and dextran sulfate sodium (DSS)‑inflamed acute colitis in replica of mice. Materials and Methods: The inflammation response in RAW‑264.7 cells was triggered with the LPS administration. The acute colitis was stimulated in BALB/c mice through administering the DSS. The colon length and disease activity index score was evaluated. The statuses of inflammatory arbitrators such as interleukin (IL)‑6, tumor necrosis factor‑α (TNF‑α), and nitric oxide (NO) and enzymatic function of myeloperoxidase were inspected via commercial kits. The matrix metalloproteinase‑2 expression in the colon tissues and colon histological examination were done to assess the deleterious effects of DSS in mice. Results: The deguelin treatment markedly alleviated the proinflammatory markers augmentation such as IL‑6, TNF‑α, and NO in the murine macrophages, as well as in DSS‑provoked colitic mice. Deguelin markedly reversed the colon shortening and also improved the colon weight. The histopathological investigation of colon tissues exposed the protective effect of deguelin. A marked alleviation in DSS‑incited colon inflammation was noted in the deguelin‑supplemented mice. Conclusion: The findings of this research were established the remedial values of deguelin against the DSS‑inflamed colitis in mice. It was clinched that the deguelin can be a promising therapeutic agent to treat the colitis.

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      Wei, F., Lu, X., Guo, X., Liu, P., Di, A., Chinnathambi, A., Alahmadi, T. A., Alharbi, S. A., & Zhang, L. (2021). Deguelin Treatment Attenuated the Lipopolysaccharides‑Provoked Inflammation in Murine Macrophage and Dextran Sulfate Sodium‑Inflamed Acute Colitis in Mice through Suppression of Inflammatory Markers. Pharmacognosy Magazine, 17(75), 451–459. https://doi.org/10.4103/pm.pm_570_19