Volume 17, Issue 75

Scientometric Analysis of Pharmacognosy Magazine: A Decade of Quality Publishing

M. Chaman Sab, Mallikarjun Kappi, KK Mueen Ahmed

pp. 399–405 · DOI: 10.4103/pm.pm_221_21 · Published 11 November 2021

Objective: This study attempt to quantitative assessment of journal productivity by the number of articles published in Pharmacognosy Magazine publications between 2011 and 2020. The present study provides a detailed sci…

In vitro Genotoxicity and in vivo Single‑Dose Oral Toxicity of Polysaccharide Fraction from the Leaves of Diospyros kaki Thunb.

Chang-Won Cho, Young-Ran Song, Youn-Hwan Hwang, Young Kyoung Rhee, Won-Chul Lim, Jae Woong Choi, Kyung-Tae Lee, Hee-Do Hong

pp. 406–412 · DOI: 10.4103/pm.pm_94_20 · Published 11 November 2021

Background: Polysaccharides isolated from medicinal herbs are regarded as important bioactive materials due to their various physiological activities. In our previous study, the polysaccharide fraction (PLE0) was separat…

Onjisaponin B Attenuates Glutamate Release via Inhibition of Calmodulin‑Dependent Protein Kinase II and Connexin 43 Pathways in Rat Astrocytes Subjected to Oxygen and Glucose Deprivation

Yingqi Mao, Yuyang Chen, Xiaoyun Pan, Lingfeng Gao, Lidan Wang, Da Li, Tao Qiu

pp. 413–418 · DOI: 10.4103/pm.pm_497_20 · Published 11 November 2021

Objectives: In this study, we aimed to investigate the effects and underlying mechanisms of onjisaponin B on the release of glutamate in rat astrocytes subjected to oxygen and glucose deprivation (OGD). Materials and Met…

Zerumbone Ameliorates the Induced Atherosclerosis‑Initiated Inflammatory Conditions through Suppression of

Proinflammatory Mediators, Inflammatory Cytokines Hemn Hassan Othman, Heshu Sulaiman Rahman, Sherwan Hamasalih Omer, Syam Mohan, Mohammed Abdulabbas Hasan, Kawa Amin, Nagi A. AL.Haj, Hareth Yahya Ahmed, Noordin Mohamed Mustapha

pp. 419–427 · DOI: 10.4103/pm.pm_549_20 · Published 11 November 2021

Objectives: This study investigated the anti‑inflammatory effect of ZER in mitigating the formation and development of early atherosclerotic lesions in rabbits fed with high‑cholesterol diet. Materials and Methods: A tot…

Systematic Analysis of Bioactive Components of Distinct Medicinal Organs of Mulberry by High‑Performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry and Molecular Docking

Jingqiong Wan, Shengrong Cheng, Yuting Wang, Chongwei Wen, Yuan Wei, Dujun Wang, Zhen Ouyang

pp. 428–437 · DOI: 10.4103/pm.pm_533_20 · Published 11 November 2021

Objectives: In this study, we aimed to systematically analyze the similarities and differences in the chemical composition of the aforementioned four medicines and to explore their bioactive components of anti‑inflammato…

Anti‑Inflammatory of Alhagi sparsifolia Shap. Extract: Network

Pharmacology Analysis, Experimental Verification Chunliu Wang, Qiqi Liu, Zhibiao Di, Hong Zhang, Ye Li, Jun Mu

pp. 438–444 · DOI: 10.4103/pm.pm_502_20 · Published 11 November 2021

Objective: The main determination of this article is to examine analgesic and anti‑inflammatory properties of chloroform fraction of Alhagi sparsifolia Shap. (CASS), wishing to deliver some basic data for further growth …

Comparative Assessment of α‑amylase and α‑glucosidase Inhibition and in vitro Antioxidant Capacity of Garcinia schomburgkiana Bark, Fruit, and Leaf Extracts

Sunan Jaisamut, Boonyadist Vongsak

pp. 445–450 · DOI: 10.4103/pm.pm_455_20 · Published 11 November 2021

Objectives: The study was to examine in vitro antioxidant potentials and inhibitory effect against α‑amylase and α‑glucosidase of the bark, fruit, and leaf extracts of G. schomburgkiana using different traditional extrac…

Deguelin Treatment Attenuated the Lipopolysaccharides‑Provoked Inflammation in Murine Macrophage and Dextran Sulfate Sodium‑Inflamed Acute Colitis in Mice through Suppression of Inflammatory Markers

Furong Wei, Xirong Lu, Xiaomin Guo, Penglin Liu, Aiting Di, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Lize Zhang

pp. 451–459 · DOI: 10.4103/pm.pm_570_19 · Published 11 November 2021

Objectives: In this investigation, we anticipated to examine the curative usefulness of deguelin, a natural herbal rotenoid against the lipopolysaccharide (LPS)‑provoked inflammatory responses in murine macrophages and d…

Effects of Grape Seed Proanthocyanidin Extract on Cisplatin‑Induced Renal Oxidative Damage and Apoptosis in Rats

Yuemei Du, Yunfan Liu, Zhang Hailian, Zhao Yanmeng, Liping Gao

pp. 460–467 · DOI: 10.4103/pm.pm_257_20 · Published 11 November 2021

Objectives: Herein, protective effects of GSPE on cisplatin (CDDP) relevant to oxidative Damage and apoptosis were investigated in rats. Materials and Methods: Randomly divide the experimental animals into five groups: R…

Comparison of Seven Chemical Components in Callicarpa nudiflora from Different Regions by Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry and its Analgesic Effect

Yunlu Peng, Yuanyan Hu, Lin Sheng, Jianping Tian, Jianlei Zhang

pp. 468–474 · DOI: 10.4103/pm.pm_365_20 · Published 11 November 2021

Objectives: This article focused on the differences in the contents of seven active chemical constituents in C. nudiflora grown in different regions. Moreover, we examined the analgesic effect of C. nudiflora from five a…

Quercetin and Flavonoids from Cuscuta chinensis Lam. Inhibit Tripterygium Glycoside‑Induced Premature Ovarian Failure Progression via PI3K‑AKT Signaling Pathway

Changsheng Huang, Yan Ning, Yancheng Guan, Mingli Luo, Ning Tan, Shicun Luo, Shoudi He, Deyu Li

pp. 475–481 · DOI: 10.4103/pm.pm_25_20 · Published 11 November 2021

Objective: In this study, we aimed to explore the effects of quercetin and flavonoids extracted from Cuscuta chinensis Lam. on tripterygium glycoside (TG)‑induced premature ovarian failure (POF). Materials and Methods: R…

Sclerocarya birrea Fruit Peel Ameliorates Diet‑Induced Obesity and Selected Parameters of Metabolic Syndrome in Female Wistar Rats

Constance R. Sewani‑Rusike, Othembela Ntongazana, Godwill Azeh Engwa, Hannibal T. Musarurwa, Benedicta N. Nkeh‑Chungag

pp. 482–491 · DOI: 10.4103/pm.pm_546_20 · Published 11 November 2021

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. <em>Crotalaria pallida</em> Aiton is a medicinal plant used in traditional medicine for various ailments. Objectiv…

Geographical Origin Discrimination of Amomi fructus using an Ultra‑Performance Liquid Chromatography‑Quadrupole Time‑of‑Flight Mass Spectrometry‑Based Metabolomics Approach Combined with Antioxidant Activity Analysis

Cai-lin Tang, De-Po Yang, Jia-li Chen, Li-Xia Zhang, Ping Ding, Xin-Jun Xu, Wen-Jian Lan, Jian-Chun Xian, Zhi-Min Zhao

pp. 492–498 · DOI: 10.4103/pm.pm_59_20 · Published 11 November 2021

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. <em>Crotalaria pallida</em> Aiton is a medicinal plant used in traditional medicine for various ailments. Objectiv…

Effect of 1,8‑Dihydroxyanthraquinone on the Imbalance of Lipid Metabolism via Regulation of Expression of CYP7A1 and 3‑Hydroxy‑3‑Methylglutaryl Coenzyme A Reductase mRNA in Hyperlipidemic Mice

Jiao Ma, Xu Liu, Jiahui Yu, Jinghui Sun

pp. 499–504 · DOI: 10.4103/pm.pm_419_20 · Published 11 November 2021

Aim: The effects of DHAQ on blood lipids and the underlying mechanisms were investigated in this study to provide a reliable experimental basis for the development and application of C. obtusifolia. Materials and Methods…

Plant Extract‑Derived Betulinic Acid Chalcone Inhibits the Development of Type 2 Diabetes Mellitus Via Targeting Peroxisome Proliferator‑Activated Receptor‑γ‑Regulated Gene Expression

Juehui Ren, Ying Wan, Yi Zhao, Min Yang

pp. 505–510 · DOI: 10.4103/pm.pm_321_20 · Published 11 November 2021

Aim: Diabetes mellitus is a syndrome related to metabolism having complicated pathogenesis and its morbidity rate is quickly increasing every year. In the present study, the antagonistic effect of betulinic acid chalcone…

Neuroprotective Effect of Cucurbita pepo in Lipopolysaccharide‑Induced Toxicity in C57BL/6 Mice

Chao Zhang, Liang Chen, Xiaoling Wang, Pingkang Pan, Yong Tang, Pengli Hui

pp. 511–517 · DOI: 10.4103/pm.pm_170_20 · Published 11 November 2021

Objectives: This study is intended to examine the protective effect of Cucurbita pepo against LPS induced neuro-inflammation in C57BL/6 mice. Materials and Methods: A single dose intraperitoneal (i.p) injection of lipopo…

Anti‑Inflammatory Effects of Malus toringoides Extract in Lipopolysaccharide‑Induced Human Umbilical Vein Endothelial Cells

Chengde Fan, Zhuoma Dongzhi, Linsha Dong, Ruiying Yuan, Jule Wang, Bin Li, Shan Huang

pp. 518–524 · DOI: 10.4103/pm.pm_357_20 · Published 11 November 2021

Objectives: The aim of the study was to explore the anti‑inflammatory effects and cellular mechanisms of extracts of M. toringoides (CBTM‑E375) in lipopolysaccharide (LPS)‑induced human umbilical vein endothelial cells (…

Anti‑osteoclastogenesis Potential Agents from Plants Naturalized in Vietnam

Thanh Huong Le, Thu Trang Duong, Phuong Thao Tran, Van Cuong Pham, Hai Dang Nguyen, Jeong-Hyung Lee

pp. 525–528 · DOI: 10.4103/pm.pm_562_20 · Published 11 November 2021

Objective: In this study, 67 plants (70 samples) were screened for osteoclastogenesis inhibitory activities on RAW264.7 mouse macrophages and bone marrow‑derived macrophages (BMMs). Materials and Methods: The RAW264.7 ce…

Antiresproative Potency of D‑carvone on Ovariectomy‑Induced Osteoporosis in Rats

Xiliang Dong, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Yanqiong Yang

pp. 529–538 · DOI: 10.4103/pm.pm_449_20 · Published 11 November 2021

Background: Osteoporosis is a quiet disease with a pathological condition of reduced bone mineral density (BMD) leading to weakened bone. In this study, we evaluated the bone formation potency of D‑carvone, an unsaturate…

Curcumin Mediates the Proliferation and Apoptosis of Colorectal Cancer Cells by Downregulating the Expression of Interleukin‑1β through the Nuclear Factor‑κB Signaling Pathway

Xiaowu Qian, Chun Jiang, Zhengtai Zhu, Gaohua Han, Ruixing Wang, Changhe Zhang

pp. 539–544 · DOI: 10.4103/pm.pm_388_19 · Published 11 November 2021

Objective: In this study, we aimed to elucidate the protective effects and mechanism of interleukin (IL)‑1 β on curcumin‑induced apoptosis in SW480 cells. Materials and Methods: Expression levels of IL‑1 β in CRC tissues…

Acute Toxicity of Oroxylum indicum Fruit Extracts in Rats

Ampa Konsue, Teeraporn Katisart

pp. 545–551 · DOI: 10.4103/pm.pm_92_21 · Published 11 November 2021

Objectives: The present study was aimed to evaluate the acute toxicity of O. indicum fruit extracts in male and female rats. Materials and Methods: The acute toxicity study was performed according to OECD guideline. The …

Tanshinone IIA Alleviates Amyloid β‑Induced Neurotoxicity of SH‑SY5Y Cells through GSK‑3β Pathway

Rongrong Huang, Songxia Lu

pp. 552–557 · DOI: 10.4103/pm.pm_249_20 · Published 11 November 2021

Background: The deposition of amyloid β (Aβ) proteins and hyperphosphorylation of tau proteins are the two notable features of Alzheimer’s disease. During the past decades, novel drug candidates have been found from natu…

Trichomes of Coleus forskohlii: Morphology and Volatile Compounds

Xiao Huang, Pengtao You, Yulin Chen, Tian Zhang, Ling Gong, Pencheng Zou, Weisong Li, Lei Wang, Yanwen Liu, Kun Yu, Bisheng Huang

pp. 558–564 · DOI: 10.4103/pm.pm_427_20 · Published 11 November 2021

Objectives: This study was intended to characterize the morphology and structure of trichomes and the profile of their secretory materials. Materials and Methods: To characterize the morphology and structure of trichomes…

Atractylodis macrocephalae Rhizoma Decoction and its Chemically Profiled Subfractions Alleviate the Side effects of Rhubarb in TCM Pair Medicine

Pei‑Yuan Dou, Lian‑Lian Zhu, Bin Li, Xia Liu, Makhotso Rose Lekhooa, De‑Qiang Dou, Muhammad Riaz

pp. 565–577 · DOI: 10.4103/pm.pm_97_21 · Published 11 November 2021

Aim: To investigate the effect of Atractylodis macrocephalae Rhizoma (AMR) and its effective constituents to alleviate the Rhubarb’s side effect in their pair medicine. Materials and Methods: The mice were administered R…

Antioral Cancer Effect of Fucoxanthin on 7,12‑Dimethylbenz[a] Anthracene‑Induced Experimental Cancer Model Hamster through Changes of Apoptosis and Cell Proliferation

Zhizheng Zhuang, Jingxuan Wang, Yingshun Yang, Yujiao Hou, Song Li, Yifan Wang, Yan Hu, Fan Wu

pp. 578–586 · DOI: 10.4103/pm.pm_482_19 · Published 11 November 2021

Background: In this study, we investigated the chemopreventive efficacy of fucoxanthin (Fx) on 7,12‑dimethylbenz[a]anthracene (DMBA)‑induced oral cancer in hamsters. Materials and Methods: Twenty‑four male Syrian golden …

Aloperine Improves Renal Fibrosis via Regulation of Toll‑Like Receptor 4/Myeloid Differentiation Factor 88 Signaling Pathway

Zhen‑Tian Cheng, Xiang‑Ping Yuan

pp. 587–593 · DOI: 10.4103/pm.pm_137_20 · Published 11 November 2021

Objectives: The primary goal of this study was to elucidate the effects and mechanisms of aloperine (Alo) in the renal fibrosis mice with unilateral ureteral obstruction (UUO). Materials and Methods: C57BL/6 mice were ra…

Antimicrobial Activity, Bioactive Constituents, and Functional Groups in Aqueous Methanol Extract of Polyalthia longifolia (Sonn.) Thwaites Leaves

Feyisara Banji Adaramola, Roger Murugas Cooposamy, Olufunmiso Olusola Olajuyigbe

pp. 594–604 · DOI: 10.4103/pm.pm_66_20 · Published 11 November 2021

Objectives: In this study, the functional groups and bioactive compounds in aqueous methanol extract of P. longifolia leaves and its antimicrobial potential were investigated. Materials and Methods: Bioactive constituent…

Modulator Effect of Mangiferin on Biochemical Characterization in 7,12‑Dimethylbenz[a]Anthracene‑Induced Oral Cancer in Experimental Hamsters

Min Liu, Chengquan Wen, Shengqi Pan

pp. 605–614 · DOI: 10.4103/pm.pm_313_19 · Published 11 November 2021

Background: Newly, chemopreventive technique might be a hopeful advancement in developing countries for treating cancers with the aid of toxic less natural‑based constituents. Malignancy urges to augment effectual chemop…

Liquiritin Enhancing Intestinal Absorption of Paeoniflorin in in situ Single‑pass Intestinal Perfusion and in vitro Caco‑2 Cell Monolayer Absorption Models

Rui He, Sihui Wang, Qing Liu, Kaili Xie, Yongsong Xu, Jinli Shi, Zhimin Wang, Muxin Gong

pp. 615–622 · DOI: 10.4103/pm.pm_47_21 · Published 11 November 2021

Objectives: In this study, we aimed to determine the interaction of paeoniflorin and liquiritin during intestinal absorption. Materials and Methods: The interaction between paeoniflorin and liquiritin (100 μM) was studie…

Antiosteoporotic Effect of Fisetin in an Estrogen Deficient Model of Osteoporosis

Cong Xu, Fei Liu, Yu Yang, Feng Yuan, Bo Zhou, Yadong Liu

pp. 623–629 · DOI: 10.4103/pm.pm_339_20 · Published 11 November 2021

Background: Osteoporosis is a serious health problem, especially in the geriatric populations. World widely, it exaggerated the 8.9 million people every year roughly. In the current analysis, we assessed the antiosteopor…

Evaluation of in vitro Cytochrome P450 Inhibition and Hepatotoxicity Potential of a Herbal Formula (Xiang Bei Yang Rong Tang) for Treatment of Cancer‑Related Fatigue

Ning Yi Yap, Sheela Packiaraj David, Huang Fang Zheng, Quan Ming Tan, Leona Yan Peng Quek, Tze Kiat Tan, Han Kiat Ho, Alexandre Chan

pp. 630–635 · DOI: 10.4103/pm.pm_522_20 · Published 11 November 2021

Objectives: In this study, the in vitro inhibition of cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2D6 (CYP2D6) activities, along with the in vitro liver cell toxicity were evaluated for XBYRT and the individual herb…

Metabolite Profiling and in vitro Evaluation of Lepisanthes fruticosa Fruit Pulp Extract as Inhibitor against Dengue and West Nile Virus NS2B‑NS3 Proteases

Suhaina Supian, Machap Chandradevan, Muhamad Aizuddin Ahmad, Lina Rozano, Mohd Shukri Mat Ali

pp. 636–642 · DOI: 10.4103/pm.pm_113_21 · Published 11 November 2021

Objectives: To evaluate the inhibitory activity of Lepisanthes fruticosa pulp extract against NS2B‑NS3 proteases from DENV2 and WNV and identify the metabolites from this fruit extract. Materials and Methods: In vitro DE…

Cardioprotective Effect of Plumbagin and Amelioration of Pro‑Inflammatory Cytokines through Suppression of Na+/ K+‑ATPase on Myocardial Ischemia

Guorong Zhang, Xinghua Ni, Yizhong Zhou

pp. 643–648 · DOI: 10.4103/pm.pm_565_20 · Published 11 November 2021

Objective: Herein, we investigated the cardioprotective effect of plumbagin in isoprenaline hydrochloride (ISO)‑induced inflammatory response and increase in antioxidant enzymes and Na+/K+‑ATPase activity in MI rats. Mat…

Pachymic acid alleviates TNBS‑induced intestine mucosal injury in mice

Jianying Zhou, Guoping Jiang, Qin Zhu, Xiaoyan Zhang, Shan Xu, Weiguang Wang, Lun Zhang, Caijuan Si

pp. 649–655 · DOI: 10.4103/pm.pm_475_20 · Published 11 November 2021

Objective: Pachyman might reduce the intestinal dysfunction and inflammation. Therefore, in this study, we aimed to explore the effect of pachymic acid on repairing the intestine mucosal injury in mice. Materials and Met…

Retraction: In vitro Antioxidant Potentials of Cyperus rotundus L. rhizome Extracts and their Phytochemical Analysis

pp. 656–656 · DOI: 10.4103/0973-1296.330202 · Published 2018