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    Article

    Anti‑osteoclastogenesis Potential Agents from Plants Naturalized in Vietnam

    Thanh Huong Le1, Thu Trang Duong2, Phuong Thao Tran3, Van Cuong Pham2, Hai Dang Nguyen1★, Jeong-Hyung Lee3★ Corresponding author

    1. 1University of Science and Technology of Hanoi.
    2. 2Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
    3. 3Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-Do 24341, Republic of Korea.

    CORRESPONDENCE

    Hai Dang Nguyen

    University of Science and Technology of Hanoi.

    nguyen‑hai.dang@usth.edu.vn

    Revised: 03-03-2021; Accepted: 06-05-2021.

    Volume 17, Issue 75 · pp. 525–528 · PUBLISHED 11 November 2021 · DOI: 10.4103/pm.pm_562_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: In this study, 67 plants (70 samples) were screened for osteoclastogenesis inhibitory activities on RAW264.7 mouse macrophages and bone marrow‑derived macrophages (BMMs). Materials and Methods: The RAW264.7 cells and the BMMs isolated from male ICR mice were treated with various doses of plant extracts and TRAP histochemical staining of the cells was performed. TRAP‑positive multinucleated cells were photographed under microscopy to observe the effects of the extracts on osteoclast differentiation. Results: Among 70 methanol extracts, we found that nine samples exhibited significant inhibitory effects in RANKL‑induced osteoclast differentiation. They included Aleurites moluccana (S16 and S17), Aporosa dioca (S19), Antidesma bunius (S21), Cinnamomum balansae (S32), Macrosolen cochinchinensis (S41), Pinus kesiya (S52), Photinia benthamiana (S54), and Mischocarpus pentapetalus (S59). Conclusion: In the present study, 70 plant extracts were screened for the osteoclastogenesis inhibitory effects in RAW264.7 murine macrophages and BMMs. Nine extracts have the potential as effective agents against osteoclastogenesis. This is the first report on the anti‑osteoclastogenetic activity of these plants.

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      Le, T. H., Duong, T. T., Tran, P. T., Pham, V. C., Nguyen, H. D., & Lee, J. (2021). Anti‑osteoclastogenesis Potential Agents from Plants Naturalized in Vietnam. Pharmacognosy Magazine, 17(75), 525–528. https://doi.org/10.4103/pm.pm_562_20