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    Article

    Antiosteoporotic Effect of Fisetin in an Estrogen Deficient Model of Osteoporosis

    Cong Xu1★, Fei Liu1★, Yu Yang1★, Feng Yuan5, Bo Zhou6, Yadong Liu7★★ Corresponding author

    1. 1Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    2. 2Department of Orthopaedics, The Third College of Clinical Medical Sciences, China Three Gorges University, Yichang, China.
    3. 3Department of Orthopaedics, Gezhouba Central Hospital, Yichang, Hubei, China.
    4. 4Department of Minimally Invasive Spine Surgery, Yu Lin Orthopaedic Hospital of Chinese and Western Medicine, Yulin, Guangxi, China.
    5. 5Sport Medicine, Shanghai Sixth People’s Hospital East Affiliated to Shanghai Univesity of Medicine and Health Sciences, Shanghai, China.
    6. 6Department of Orthopedics, Yixing People’s Hospital, Yixing, Jiangsu, China.
    7. 7Department of Microsurgery of Hand and Foot Ankle, Affliated Dongfeng Hospital, Hubei University of Medicine (Sinopharm Dongfeng General Hospital), Shiyan, Hubei, China.

    CORRESPONDENCE

    Cong Xu

    Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

    Yadong1116@sina.com

    Received: 25-08-2020; Revised: 12-10-2020; Accepted: 09-03-2021.

    Volume 17, Issue 75 · pp. 623–629 · PUBLISHED 11 November 2021 · DOI: 10.4103/pm.pm_339_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Osteoporosis is a serious health problem, especially in the geriatric populations. World widely, it exaggerated the 8.9 million people every year roughly. In the current analysis, we assessed the antiosteoporotic effect of fisetin on the osteoporosis model ovariectomized (OVX) rat. Materials and Methods: Fisetin was orally administrated at dose of 5, 10, and 20 mg/kg to OVX rats for 16 weeks. Different biochemical parameters such as alkaline phosphatase (ALP), osteocalcin, phosphorus, calcium, and urinary deoxypyridinoline were also projected. 3‑point bending test, bone mineral density (BMD), and histomorphometric feature of the femoral bone were also examined. Results: Fisetin significantly decreased the body weight and increased the uterine weight. A significant decrease detected in the level of ALP, serum calcium, while the level of the serum phosphorus, OC augmented after fisetin administration. Fisetin significantly (P < 0.001) reduced the homocysteine, C‑terminal crosslinked telopeptides of collagen type I, interferon gamma, and increased the level of OC. Fisetin also augmented the level of BMD. Fisetin considerably increased the energy, maximum load, maximum stress, young modulus, and stiffness. The level of cytokines such as tumor necrosis factor‑α, interleukin (IL)‑6, and IL‑1 β also diminished pointedly after fisetin treatment. Fisetin significantly boosted the estrogen (E2) level and reduced the level of follicle‑stimulating hormone and luteinizing hormone. Conclusion: Communally, we can accomplish that fisetin exhibited the better protection against osteoporosis through augmenting the bone density and bone mineral content in addition to biomechanical parameters.

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      Xu, C., Liu, F., Yang, Y., Yuan, F., Zhou, B., & Liu, Y. (2021). Antiosteoporotic Effect of Fisetin in an Estrogen Deficient Model of Osteoporosis. Pharmacognosy Magazine, 17(75), 623–629. https://doi.org/10.4103/pm.pm_339_20