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    Arbortristoside‑A: A Promising Bioactive Moiety from Nyctanthes arbortristis Linn. against Hemorrhoid

    Sanjita Das1★, Saumya Das1, Aniruddh Pratap Singh2, Manas Kumar Das3, Nishu Gautam4, P. Ayash Kumar5, Sradhanjali Mohapatra6, Richa Shakya1★ Corresponding author

    1. 1Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park II, Greater Noida, India.
    2. 2Anand College of Pharmacy, Agra, India.
    3. 3Orlean College of Pharmacy, India.
    4. 4GNIOT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
    5. 5Research and Development Centre, Gurugram, Haryana, India.
    6. 6School of Pharmaceutical Education and Research, New Delhi, India.

    CORRESPONDENCE

    Sanjita Das

    Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park II, Greater Noida, India.

    sanjita8@yahoo.co.in

    Received: 21-12-2020; Revised: 29-07-2021; Accepted: 09-09-2021.

    Volume 17, Issue 76 · pp. 695–699 · PUBLISHED 24 January 2022 · DOI: 10.4103/pm.pm_573_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Hemorrhoid disease is becoming a common problem in modernized society and its treatment is less developed. Although there are many plants used traditionally, proper scientific evidence is still lacking. Nyctanthes arbortristis Linn. is scientifically proved to have pharmacological activities. In this research work, an approach has been made to establish the potentiality of arbortristoside‑A from N. arbortristis L. seeds against hemorrhoid. Materials and Methods: After characterization of arbortristoside‑A from N. arbortristis L seeds, it was subjected to explore its effectiveness against hemorrhoid using rat ileum and following croton oil‑induced hemorrhoid screening models. Results: Arbortristoside‑A observed to have a significant reduction in inflammation due to hemorrhoid at 50 and 100 mg/kg (1.25 ± 0.06 and 0.76 ± 0.05, respectively). Reduction of severity scores was observed in animals due to arbortristoside‑A mainly at its higher dose 100 mg/kg. It was also found to decrease the rectoanal coefficient significantly. Conclusion: Oral administration of arbortristoside‑A was proved to have significant anti-hemorrhoid effect which was well compared to that of the standard drug. In the course of time, this research work will be helpful in providing new entities to the field of medicines and pharmaceutical sciences for the treatment of hemorrhoid.

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      Das, S., Das, S., Singh, A. P., Das, M. K., Gautam, N., Kumar, P. A., Mohapatra, S., & Shakya, R. (2022). Arbortristoside‑A: A Promising Bioactive Moiety from Nyctanthes arbortristis Linn. against Hemorrhoid. Pharmacognosy Magazine, 17(76), 695–699. https://doi.org/10.4103/pm.pm_573_20