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    Chemopreventive Strategies of Teucrium alopecurus de Noé Water Insoluble Fraction for Hepatocarcinogenesis in Lipopolysaccharide‑Induced Mice Models: Pharmacological Attributes

    Fatma Guesmi1★, Manel Ben Ali2, Ramla Ben Mouhoub1, Amor Hedfi2, Mohammad S. AL-Harbi2, Ahmed Landoulsi1★ Corresponding author

    1. 1Department of Biology, Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences of Bizerte, University of Carthage, Tunis, Tunisia, Saudi Arabia.
    2. 2Department of Biology, College of Sciences, Taif University, Taif, Saudi Arabia.

    CORRESPONDENCE

    Fatma Guesmi

    Department of Biology, Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences of Bizerte, University of Carthage, Tunis, Tunisia, Saudi Arabia.

    guesmif10@gmail.com

    Received: 24-12-2020; Revised: 13-09-2021; Accepted: 12-11-2021.

    Volume 17, Issue 76 · pp. 865–871 · PUBLISHED 24 January 2022 · DOI: 10.4103/pm.pm_585_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: The goal of this study is to investigate the inhibitory potential of TAlp in lipopolysaccharide (LPS)‑induced hepatic damage. Methods: Cell viability was measured by 3‑(4, 5‑dimethylthiazol‑2‑yl)‑2, 5‑diphenylbromide (Thiazolyl blue tetrazolium blue) assay. We treated tumor cells with TAlp essential oil (0.005 and 0.01 µg/ml) and curcumin (10 µM). Apoptosis was determined by flow cytometry. Therefore, we carried out the in vivo malignant hepatoma induced by LPS and the preventive effect of water‑insoluble fraction extracted from aerial parts of TAlp. Moreover, the hepatoprotective effect was investigated by the determination of serum levels of lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase. Results: Our results indicated the significant anti‑proliferative effects of TAlp on colon tumor cell lines alone or in combination with curcumin. Moreover, hepatocellular inflammation induced by LPS increases metastasis in liver cells and was suppressed by intragastric administration of TAlp essential oil. Inflammation is tightly associated with carcinogenesis at both the initiation and development of tumor. Conclusion: Overall, the Tunisian plants showed potency in the prevention of hepatocarcinogenesis.

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      Guesmi, F., Ali, M. B., Mouhoub, R. B., Hedfi, A., AL-Harbi, M. S., & Landoulsi, A. (2022). Chemopreventive Strategies of Teucrium alopecurus de Noé Water Insoluble Fraction for Hepatocarcinogenesis in Lipopolysaccharide‑Induced Mice Models: Pharmacological Attributes. Pharmacognosy Magazine, 17(76), 865–871. https://doi.org/10.4103/pm.pm_585_20