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    Article

    Efficacy of Bisacurone in Bone Fracture Healing Process: An Experimental Study on Osteoporotic Rats

    Minjie Li1, Weiwei Feng2, Wenping Zhang3, Zhonghui Pang1, Shaokun Pei1, Lifeng Xia1, Qiang Li1, Huixiao Li1★★ Corresponding author

    1. 1Department of Orthopedics, The Fourth People’s Hospital of Shaanxi, Xi’an, China
    2. 2Department of Maxillofacial Oncology, The Third Affiliated Hospital of Air Force Military Medical University, Xi’an, China
    3. 3Department of Blood Transfusion, The First Affiliated Hospital of Air Force Military Medical University, Xi’an, China

    CORRESPONDENCE

    Huixiao Li

    Department of Orthopedics, The Fourth People’s Hospital of Shaanxi, Xi’an - 710043, China.

    lihx3155531@outlook.com

    Received: 01-10-2021; Revised: 08-03-2022; Accepted: 11-03-2022.

    Volume 18, Issue 78 · pp. 304–313 · PUBLISHED 7 July 2022 · DOI: 10.4103/pm.pm_450_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Osteoporosis (OP) is a common disorder resulting in bone fragility and fracture. Due to OP, bone mass and microarchitectural bone tissues are damaged, increasing the risk of fracture. Objectives: To determine the efficacy of bisacurone in healing fractured bones and its inflammatory response in ovariectomy (OVX)‑induced OP in female rats. Materials and Methods: After inducing fracture in femur bone, bisacurone (25, 50, and 100 μg/kg) and alendronate (20 mg/kg) were orally administered to rats for 8 weeks. Subsequently, its fracture healing and anti‑inflammatory potential were evaluated via assessment of various biochemical and molecular parameters. Results: Bisacurone therapy significantly (P < 0.05) increased the calcium content, serum calcium, and phosphorus in OVX‑induced OP rats. It significantly (P < 0.05) reduced the serum alkaline phosphate (ALP); urine biochemical parameters such as urinary calcium, phosphorus, and creatinine; and inflammatory cytokines such as interleukin‑6 (IL‑6) and tumor necrosis factor α (TNF‑α). Moreover, bisacurone was found to be significantly (P < 0.05) effective in downregulating the bone turnover markers such as osteocalcin, receptor activator of nuclear factor‑kappa‑Β ligand (RANKL), peroxisome proliferator‑activated receptor gamma (PPAR‑γ), and upregulating osteoprotegerin (OPG), runt‑related transcription factor 2 (Runx2), and AMP‑activated protein kinase (AMPK) in OVX‑induced OP rats. Conclusion: Bisacurone effectively healed the fracture and improved the bone quality in arthritic conditions by reducing inflammatory cytokines and altering the level of bone turnover markers. Therefore, bisacurone therapy should be considered for the management of fracture healing process in the arthritic conditions.

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      Li, M., Feng, W., Zhang, W., Pang, Z., Pei, S., Xia, L., Li, Q., & Li, H. (2022). Efficacy of Bisacurone in Bone Fracture Healing Process: An Experimental Study on Osteoporotic Rats. Pharmacognosy Magazine, 18(78), 304–313. https://doi.org/10.4103/pm.pm_450_21