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    Article

    Exploring Cross‑linked Tragacanth as Novel Excipient‑proof‑of‑concept

    Anroop B. Nair1★, Santosh Fattepur2, N. Raghavendra Naveen3★, Prakash Goudanavar3, Naga Prashant Koppuravuri4, Buduru Gowthami5, Mallikarjun Telsang6, Riyaz Ali Osmani7, Nagaraja Sreeharsha1,8, Mohammed Habeebuddin9★ Corresponding author

    1. 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa, Saudi Arabia
    2. 2School of Pharmacy, Management and Science University, Shah Alam, Selangor, Malaysia
    3. 3Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka
    4. 4Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka
    5. 5Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India
    6. 6Department of Medicine, College of Medicine, King Faisal University, Al‑Ahsa, Saudi Arabia
    7. 7Nanomedicine Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay (IIT-B), Mumbai
    8. 8Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bengaluru, India
    9. 9Department of Biomedical Sciences, College of Medicine, King Faisal University, Al‑Ahsa, Saudi Arabia

    CORRESPONDENCE

    Anroop B. Nair

    Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al‑Ahsa, 31982, Saudi Arabia.

    anair@kfu.edu.sa

    Received: 26-12-2021; Revised: 05-01-2022; Accepted: 12-01-2022.

    Volume 18, Issue 78 · pp. 314–320 · PUBLISHED 7 March 2022 · DOI: 10.4103/pm.pm_601_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Tragacanth, a natural gum, is frequently used as stabilizer for colloidal systems and as a binder in tablets. Materials from natural sources are in increasing demand to solve the current global environmental problems arising from synthesis involving petroleum‑based substances. Objectives: In this context, we improved functionality of tragacanth through crosslinking and extended its application for directly compressed fast dissolving systems. Fast dissolving formulations upon settling on the tongue disintegrate promptly and release the medicament, thus making it especially suitable for paediatrics, geriatrics, bedbound, or incapacitated patients. Materials and Methods: Cross‑linked tragacanth (CLT) was explored as a potent disintegrant and compared with sodium starch glycolate and Crospovidone for its effect on compressibility and release of metoclopramide hydrochloride from tablets made by direct compression and sublimation method. Formulations made using CLT were optimized for swelling capacity, absorption efficiency, and moisture sorption capacity. Results: The most appropriate controls for linkage of tragacanth were 1:0.4 proportion of tragacanth: Epichlorohydrin, at 105°C temperature for 45 min of reaction. Prepared formulations showed desired disintegration and wetting time. Formulations made using camphor showed porosity because of sublimation and favored rapid disintegration. Based on the drug release study, it is confirmed that formulation with 4% CLT and 20% camphor prepared by sublimation process exhibited highest drug release, i. e. 99.23% within 15 min. Conclusion: This study demonstrates the novel applicability of tragacanth as an effective natural superdisintegrant after cross‑linking and provides a sustainable alternative to synthetic superdisintegrants while formulating the fast‑disintegrating tablets.

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      Nair, A. B., Fattepur, S., Naveen, N. R., Goudanavar, P., Koppuravuri, N. P., Gowthami, B., Telsang, M., Osmani, R. A., Sreeharsha, N., & Habeebuddin, M. (2022). Exploring Cross‑linked Tragacanth as Novel Excipient‑proof‑of‑concept. Pharmacognosy Magazine, 18(78), 314–320. https://doi.org/10.4103/pm.pm_601_21