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    Exploring the Topical Gel of Thespesia populnea leaf Extract for in vivo Wound Healing Efficacy

    Afzal H. Asif2, Salim M. Mulla6, Arshia Shariff3,6,7, Nagaraja Sreeharsha3,7★, Girish Meravanige4, Predeepkumar N. Shiroorkar4, Syed Mohammed Basheeruddin Asdaq8, Md. Khalid Anwer9, Teeka S. Roopashree10, Ranjith K. Karnati5★ Corresponding author

    1. 1Department of Pharmacy Practice, College of Clinical Pharmacy, India.
    2. 2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, India.
    3. 3Department of Biomedical Sciences, College of Medicine, India.
    4. 4Department of Chemistry, College of Science, King Faisal University, Al‑Ahsa, Saudi Arabia.
    5. 5Department of Pharmaceutics, Alard College of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India.
    6. 6Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bangalore, Karnataka, India.
    7. 7Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, India.
    8. 8Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al‑Alkharj, Saudi Arabia.
    9. 9Department of Pharmacognosy, Government College of Pharmacy, Bangalore, Karnataka, India.

    CORRESPONDENCE

    Nagaraja Sreeharsha

    Department of Biomedical Sciences, College of Medicine, India.

    sharsha@kfu.edu.sa

    Received: 18-01-2022; Revised: 23-05-2022; Accepted: 25-05-2022.

    Volume 18, Issue 79 · pp. 519–523 · PUBLISHED 30 May 2022 · DOI: 10.4103/pm.pm_25_22

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Aim: Thespesia populnea is a plant known for its polyphenol and flavonoid content, which plays a crucial role in wound healing activity. Traditionally, extracts of various parts of T. populnea plant have been used to treat various skin diseases including wound healing. Therefore, we made a topical gel containing alcoholic extracts of the leaves of T. populnea for antimicrobial and wound healing activities. Materials and Methods: Extracts of T. populnea were successfully obtained by Soxhlet extraction. Phytochemical screenings were performed to estimate the presence of different metabolites. Combinations of carbopol and propylene glycol were optimized through 32 factorial design for desirable gel characteristics. Results and Discussions: Formulated gel was pale brown in color having viscosity of 90,300 cps with acceptable spreadability and extrudability index. Antimicrobial studies showed inhibition activity. The in vivo wound healing studies demonstrated comparable healing properties with respect to marketed Soframycin gel. Furthermore, histopathological studies on Wistar rats also confirmed the same. Conclusion: It can be concluded that the formulated gel is beneficial in topical applications, which can be a beacon for new skin regeneration and wound healing therapies that focuses on herbal remediation.

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      Asif, A. H., Mulla, S. M., Shariff, A., Sreeharsha, N., Meravanige, G., Shiroorkar, P. N., Asdaq, S. M. B., Anwer, M. K., Roopashree, T. S., & Karnati, R. K. (2022). Exploring the Topical Gel of Thespesia populnea leaf Extract for in vivo Wound Healing Efficacy. Pharmacognosy Magazine, 18(79), 519–523. https://doi.org/10.4103/pm.pm_25_22