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    Article

    Alterations in the Pharmacokinetics of Paeoniflorin and Albiflorin in a Collagen‑Induced Arthritis Rat Model

    Ya-xin Han2,3, Mu-xin Gong2★, Jin-e Peng4, Yong-song Xu5, Feng Qiu2, Kai-li Xie2, Xue-rong Dong2, Bin-bin Wang2, Xiao-xin Chai2, Zhe Ma2, Si-hui Wang2, Nan Nan2★ Corresponding author

    1. 1Department of Pharmaceutics of TCM, Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
    2. 2Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100029, China.
    3. 3Department of Pharmacy, Beijing Ditan Hospital Capital Medical University, Beijing 100015, China.
    4. 4Beijing Key Laboratory of Diabetes Research and Care, Center for Endocrine Metabolism and Immune Diseases, Luhe Hospital Capital Medical University, Beijing 101149, PR, China.

    CORRESPONDENCE

    Mu-xin Gong

    Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100029, China.

    gongmuxin@ccmu.edu.cn

    Received: 22-11-2021; Revised: 25-03-2022; Accepted: 27-04-2022.

    Volume 18, Issue 79 · pp. 571–578 · PUBLISHED 19 September 2022 · DOI: 10.4103/pm.pm_539_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Rheumatoid arthritis (RA) is an autoimmune disease that seriously affects the patient’s quality of life. Total glucosides of peony (TGP) have long been used to treat RA in China despite the need for long‑term administration. The main active ingredients in TGP are paeoniflorin (PF) and albiflorin (AF). This study aimed to clarify the effective mechanism of TGP only after long‑term administration, and the pharmacokinetics of PF and AF following single and chronic oral TGP administration in collagen‑induced arthritic (CIA) and normal rats. Materials and Methods: Comparative pharmacokinetic studies of TGP were conducted in male Sprague Dawley rats. Plasma concentrations of PF and AF were determined with ultra‑high performance liquid chromatography– tandem mass spectrometry (UPLC‑MS/MS). DAS software was used to estimate pharmacokinetic parameters. Results: Bimodal phenomenon was observed. After a single TGP dose, the absorption of AF and PF were both lower in CIA rats compared to control rats. Compared with single‑dose groups, the absorption of AF and PF in CIA rats increased after long‑term administration of TGP. No significant differences were seen between the groups after chronic administration in low‑dose groups in normal rats. Conclusion: We found that after long‑term administration of TGP, the absorption of PF and AF are promoted in CIA rats. These results, combined with the existing literature, may help substantiate the TGP‑related changes in gut microbiota.

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      Han, Y., Gong, M., Peng, J., Xu, Y., Qiu, F., Xie, K., Dong, X., Wang, B., Chai, X., Ma, Z., Wang, S., & Nan, N. (2022). Alterations in the Pharmacokinetics of Paeoniflorin and Albiflorin in a Collagen‑Induced Arthritis Rat Model. Pharmacognosy Magazine, 18(79), 571–578. https://doi.org/10.4103/pm.pm_539_21