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    Article

    Phytochemical Profiling of Different Processed Products from Atractyloidis Rhizome using UHPLC/Q-TOF-MS

    Honglian Zhang1, Yumei Wang1, Dongmei Wang2, Jikai Sun1, Zhiguo Zhang2, Jinghan Wang1, Jun Liu1, Qi Liu1★★ Corresponding author

    1. 1The Research Institute of Medicine and Pharmacy, The Pharmacy School, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
    2. 2The Second Afliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China.

    CORRESPONDENCE

    Qi Liu

    The Research Institute of Medicine and Pharmacy, The Pharmacy School, Qiqihar Medical University, Qiqihar, Heilongjiang, China.

    liuqi_hlj@163.com

    Received: 11-02-2022; Revised: 25-04-2022; Accepted: 01-08-2022.

    Volume 18, Issue 80 · pp. 1075–1081 · PUBLISHED 23 November 2022 · DOI: 10.4103/pm.pm_70_22

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: To unscramble the phytochemical profiling of CZO, CZP, BCZ, and JCZ. Materials and Methods: In this paper, ultra‑high performance liquid chromatography combined with quadrupole time‑of‑flight mass spectrometry (UHPLC‑Q‑TOF‑MS/ MS) technology and multivariate data analysis methods such as principal component analysis (PCA) and orthogonal partial least squares discrimination analysis (OPLS‑DA) were employed to screen the different components among CZO, CZP, BCZ, and JCZ. Results: As a result, CZO, CZP, BCZ, and JCZ were separated obviously in PCA plot, and a total of 101 components were identified successfully. Among them, 54 chemical markers, including isoleucine, citric acid, L‑phenylalanine, atractyloside A, etc., discriminating among CZO, CZP, BCZ, and JCZ, were screened out. Conclusion: UHPLC‑Q‑TOF‑MS/MS technology combined with PCA and OPLS‑DA could be successfully applied in clarifying the different ingredients between crude drug and its processed products of traditional Chinese medicine (TCM). Importantly, the established method revealed the reasonability of processing theory in TCM.

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      Zhang, H., Wang, Y., Wang, D., Sun, J., Zhang, Z., Wang, J., Liu, J., & Liu, Q. (2022). Phytochemical Profiling of Different Processed Products from Atractyloidis Rhizome using UHPLC/Q-TOF-MS. Pharmacognosy Magazine, 18(80), 1075–1081. https://doi.org/10.4103/pm.pm_70_22