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    Article

    Aegle marmelos Ameliorates Epilepsy through Suppression of Oxidative Stress and Inflammation

    Xiaoyan Wang2, Lihong Liu3, Huilan Zhang4, Xiaoyan Liu5, Hui Liu2★★ Corresponding author

    1. 1The Third Departments of, China.
    2. 2Neurology, China.
    3. 3Thoracic Surgery, China.
    4. 4Ophtalmology and, China.
    5. 5Respiratory Medicine, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

    CORRESPONDENCE

    Hui Liu

    Neurology, China.

    lhzxyy@hotmail.com

    Received: 16-04-2022; Revised: 29-06-2022; Accepted: 22-07-2022.

    Volume 18, Issue 80 · pp. 871–878 · PUBLISHED 23 November 2022 · DOI: 10.4103/pm.pm_173_22

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: We induced epilepsy in zebrafish through the administration of pentylenetetrazole as a model organism. Materials and Methods: To assess the anti‑epileptic potency of plant extract, behavioural changes were recorded and analysed by Behavioural Observation Research Interactive Software. Further, oxidative stress, glutathione peroxidase and lipid peroxidation (LPO) levels were estimated. Real‑time polymerase chain reaction was performed to quantify the expression of inflammatory markers tumour necrosis factor‑alpha (TNFα) and interleukin 1 beta (IL‑1β). Results: Epilepsy‑induced animals displayed a pronounced behavioural change in swimming patterns and preference for darkness and stayed longer periods at the bottom of the tank. On the other hand, plant extract treated animals reversed the behavioural alterations induced by epilepsy. Oxidative stress was seen in animals induced with epilepsy and the same was reversed in animals that were treated with plant extract. LPO was elevated in epilepsy whereas plant extract reduced the same. Inflammatory markers such as TNFα and IL‑1β levels were higher in epileptic animals whereas their expression levels were reduced by treatment with the plant extract. Histopathological examination also revealed the inflammatory reaction in the brain induced by epilepsy. Conclusion: Treatment with the plant extract restored the tissue architecture to normal. Overall, there was a major reversal of behaviour, oxidative stress and inflammation upon treatment with the plant extract indicating the anti‑epileptic potential of AM.

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      Wang, X., Liu, L., Zhang, H., Liu, X., & Liu, H. (2022). Aegle marmelos Ameliorates Epilepsy through Suppression of Oxidative Stress and Inflammation. Pharmacognosy Magazine, 18(80), 871–878. https://doi.org/10.4103/pm.pm_173_22