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    Cognitive Enhancing Activity of Fermented Aloe arborescens Extract on Scopolamine-induced Memory Impairment in Mice

    GiBeom Jeon1, Seong Hun Lee2, Yong Seong Kwon2, Jin Hong Beak2, Hyeon Lee1, Choong Je Ma3,4★★ Corresponding author

    1. 1R&DB Center, Beauty Science Ltd, Sejong, SOUTH KOREA.
    2. 2R&D Center, KJM Aloe Co. Ltd., Seoul, SOUTH KOREA.
    3. 3Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, SOUTH KOREA.
    4. 4Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, SOUTH KOREA.

    CORRESPONDENCE

    Choong Je Ma

    Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, SOUTH KOREA.

    cjma@kangwon.ac.kr

    Received: 20-04-2022; Accepted: 20-09-2022.

    Volume 19, Issue 1 · pp. 5–12 · PUBLISHED 2023 · DOI: 10.1177/09731296221137408

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Alzheimer’s disease (AD) is a type of dementia that leads to loss of memory and learning ability. Aloe arborescens is a traditional medicinal plant in Europe and Africa. It has been reported that A. arborescens showed antiinflammatory, anti-cancer, antioxidant, and anti-obesity effects. Previously, we reported that fermented A. arborescens extract had neuroprotective activity in glutamate-insulted HT22 cells. Materials and Methods: In this study, we evaluated its cognitive enhancing activity by using scopolamine-induced memory impairment in mice as a model system. Morris water maze test was carried out to evaluate spatial memory enhancing activity and a passive avoidance test was performed to evaluate an effect on learning memory. A. arborescens was extracted with methanol in an ultrasonic extraction device and fermented with Lactobacillus brevis. Fermented A. arborescens extract was treated to scopolamine-insulted Institute of Cancer Research (ICR) mice at a concentration of 100, 200, and 300 mg/kg, respectively. Results: The fermented A. arborescens extract significantly improved the scopolamine-insulted memory impairment. Fermented A. arborescens extract inhibited acetylcholine esterase activity and boosted brain-derived neurotrophic factor and phosphorylated cAMP-response element-binding protein (p-CREB) expression. These results showed that fermented AA extract improved memory impairment through the increase of the BDNF and p-CREB signal pathway. Conclusion: According to these results, we considered that the fermented A. arborescens extract can be a useful candidate for new nutraceuticals for improving memory impairment.

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      Jeon, G., Lee, S. H., Kwon, Y. S., Beak, J. H., Lee, H., & Ma, C. J. (2023). Cognitive Enhancing Activity of Fermented Aloe arborescens Extract on Scopolamine-induced Memory Impairment in Mice. Pharmacognosy Magazine, 19(1), 5–12. https://doi.org/10.1177/09731296221137408