Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Simultaneous Quantification of 30 Elements in the Mineral Chinese Medicine Quartz Album by ICP-MS for the Identification of Different Geogenesis

    Chenyu Xu1,2, Xingyu Zhu1,3, Yulu Ma1,2, Baofei Yan1,4, Shilin Dai1,2, Xiuxiu Wang5, Jin Zhao5, Yin Wang1,2, Sichen Wu1,2, Qian Zhao6, Xiaohua Bao7, Wenguo Yang1,2, Fang Fang1,2, Shengjin Liu1,2★★ Corresponding author

    1. 1College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
    2. 2Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, China.
    3. 3Jiangsu College of Nursing, Huai’an, China.
    4. 4Jiangsu Health Vocational College, Nanjing, China.
    5. 5Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
    6. 6East China Geological Exploration Bureau of Nonferrous Metals, Nanjing, China.
    7. 7Inner Mongolia University for Nationalities, Tongliao, China.

    CORRESPONDENCE

    Shengjin Liu

    Yulu Ma,College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. ; Shengjin Liu,Nanjing University of Chinese Medicine, Nanjing 210023, China. Email: lsj@njucm.edu.cn

    scutmayulu@njucm.edu.cn

    Received: 15-12-2022; Accepted: 28-02-2023.

    Volume 19, Issue 3 · pp. 592–602 · PUBLISHED 2023 · DOI: 10.1177/09731296231171443

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Quartz album is one of the mineral drugs commonly used in Chinese medicine. Different geogenesis of Quartz album led to differences in its composition and thus affected its clinical efficacy. Mineral Chinese medicines are mainly composed of inorganic elements, including some heavy metals and harmful elements, so their quality control is crucial to their clinical safety. Materials and Methods: In this study, the contents of 30 elements in 13 batches Quartz album of different origins were determined by inductively coupled plasma mass spectrometry (ICP-MS). Multiple elements and chemometrics were used to distinguish its different geogenesis. Results: We found that the top elements in order of content were as follows: Al>Fe>Ca>K>Mg>Ti>Mn, all with content greater than 100 μg/g. In addition, the contents ranges of Pb, Cd, As, Hg, and Cu were 1.603–637.705, 0.011–1.387, 0.348– 41.298, 0.033–10.877, and 0.808–86.482 μg/g, respectively. Quartz albums produced in Fengyang County, Anhui Province, had the lowest content of heavy metals. Correlation analysis showed that there was a strong correlation among the elements in the samples. Chemometrics were used to analyze the elemental content, and the results of the different models were found to be consistent and could be used to distinguish between Quartz albums of different geogenesis. Conclusion: This study provided a reference for the quality control and safety of the clinical application of Quartz album.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Xu, C., Zhu, X., Ma, Y., Yan, B., Dai, S., Wang, X., Zhao, J., Wang, Y., Wu, S., Zhao, Q., Bao, X., Yang, W., Fang, F., & Liu, S. (2023). Simultaneous Quantification of 30 Elements in the Mineral Chinese Medicine Quartz Album by ICP-MS for the Identification of Different Geogenesis. Pharmacognosy Magazine, 19(3), 592–602. https://doi.org/10.1177/09731296231171443