Volume 19, Issue 3

Original Article

1. Article

   Synthesis and Characterization of Citrus limonum Copper Nanoparticles and its in vitro Evaluation of Cytotoxicity against JURKAT Cells

   Huda Jameel Makki, KS Chandrasekharaiah

   pp. 499–508 · DOI: 10.1177/09731296231177492 · Published 2023

   Background: Biosynthesized copper nanoparticles (CuNPs) are eco-friendly, cost-effective, and biocompatible agents reported for extensive biomedical and bioengineering applications. Different chemical synthesis approache…

2. Article

   Fruit of Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils Attenuates DSS-induced Ulcerative Colitis by Adjusting Nrf2/NF-κB Signaling Pathway

   Teng Wang, Jialong Lei, Qiaqia Han, Yanmin Zhao, Xiaoxia Gao, Jingze Zhang, Dailin Liu

   pp. 509–519 · DOI: 10.1177/09731296231170095 · Published 2023

   Background: Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils (FOE), a sort of ethnodrug from the Yi nationality called “GU-GONG-GUO,” the root of which has been shown to have the effect of relieving diarr…

3. Article

   Determination of the Genomic DNA Degradation Rate of the Chinese Herb Gentianae crassicaulis Radix During Processing and Storage

   Weitao Li, Shaohua Yang, Lianghong Ni, Zhili Zhao, Hongxi Xu

   pp. 520–529 · DOI: 10.1177/09731296231170254 · Published 2023

   Background: Accurate identification of Chinese herbal medicines is the basis for their research and utilization. Molecular identification can effectively differentiate original plants from counterfeit plants. The quality…

4. Article

   Inhibitory Activities of Extracts from Chinese Medicinal Herbs on α-Amylase, α-Glucosidase, and Pancreatic Lipase

   Xiang Liu, Yuhao Nie, Rui Chen, Xiaoying Zhang, Lijuan Yue, Chen Chen

   pp. 530–538 · DOI: 10.1177/09731296231168739 · Published 2023

   Background: Metabolic syndrome is an assortment of conditions that often happens together and upsurge your risk of diabetes, stroke, and heart disease. One strategy for the prophylaxis and treatment of diabetes and obesi…

5. Article

   Multi-therapeutic and Biomolecular Exploration of Andrographolide against Bacterial-induced Oxidative and Inflammatory Damages

   Maryam M. Alnoman

   pp. 539–550 · DOI: 10.1177/09731296231171219 · Published 2023

   Aim/Background: Oxidative and inflammatory damage induced by bacterial infections has been attributed as a more concerning health issue raised by health professionals and researchers due to large antibiotic drug resistan…

6. Article

   Screening the Chemical Composition and Bioactivity of Cerasus serrulata Flower Extracts Using Two Extraction Methods

   Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Xiaomin Zheng, Siyang Zhu, Baoshan Rong, Yong Ai, Lanyue Zhang, Tinggang He

   pp. 551–563 · DOI: 10.1177/09731296231173558 · Published 2023

   Background: Cerasus serrulata has an excellent antioxidative, antibacterial, and anti-alopecia effect, but its active ingredients and the underlying mechanism are currently unclear, in addition to the fact that the activ…

7. Article

   Fucoidan Attenuated Kidney and Bone Damage Caused by CKD-MBD in Mice by Upregulating Klotho

   Tao Lu, Mang Dou, Chengyi Yang, Qiangyan Hu, Yin’e Wang, Suxia Pan

   pp. 564–573 · DOI: 10.1177/09731296231172549 · Published 2023

   Background: Fucoidan is a phosphorylated polysaccharide extracted from seaweed that has a renal protective effect. However, whether Fucoidan can be used to prevent chronic kidney disease with mineral and bone disorders (…

8. Article

   Highly Effective Extraction of Gigantol from Dendrobium officinale Using the Ultrasonic-assisted Dry Grinding

   Yufeng Sun, Xiuxia Zheng, Dong Zhu, Dongyan Guan, Bei Fan, Fengzhong Wang

   pp. 574–580 · DOI: 10.1177/09731296231168747 · Published 2023

   Background: Dendrobium officinale is a valuable medicinal food plant in China, and its component gigantol has various biological activities. However, due to the low extraction rate of gigantol, its application in the fun…

9. Article

   Exploring the Potential of Spirulina (Arthrospira platensis) Aqueous Extract in Preventing Glycation of Hemoglobin and pBR322 Plasmid

   Additiya Paramanya, Mohammad Abul Farah, Khalid Mashay Al-Anazi, Hari Prasad Devkota, Ahmad Ali

   pp. 581–591 · DOI: 10.1177/09731296231170959 · Published 2023

   Background: Spirulina (Arthrospira platensis), a cyanobacterium, is being consumed worldwide owing to its high nutritional value and therapeutic potential. Objectives: This study aims to determine the phytochemical conte…

10. Article

    Simultaneous Quantification of 30 Elements in the Mineral Chinese Medicine Quartz Album by ICP-MS for the Identification of Different Geogenesis

    Chenyu Xu, Xingyu Zhu, Yulu Ma, Baofei Yan, Shilin Dai, Xiuxiu Wang, Jin Zhao, Yin Wang, Sichen Wu, Qian Zhao, Xiaohua Bao, Wenguo Yang, Fang Fang, Shengjin Liu

    pp. 592–602 · DOI: 10.1177/09731296231171443 · Published 2023

    Background: Quartz album is one of the mineral drugs commonly used in Chinese medicine. Different geogenesis of Quartz album led to differences in its composition and thus affected its clinical efficacy. Mineral Chinese …

11. Article

    Anti-Photoaging Effects of the Ethanol Extract from Eucommia ulmoides Oliv. Seed Meal on UVB-irradiated HaCaT Cells and Mice

    Tong Wang, Xiangyu Wang, Yan Li, Mi Xie, Liying Gao, Yuefei Wang, Bin Li, Shan Huang

    pp. 603–614 · DOI: 10.1177/09731296231170932 · Published 2023

    Background: Eucommia ulmoides Oliv. is a traditional Chinese medicine, and its flowers, leaves, and seeds are widely used as food. Currently, E. ulmoides seed oil is capable of improving glucose and lipid metabolism in t…

12. Article

    Bioactivity Screening of Thirty Black Turmeric (Curcuma caesia Roxb.) Essential Oils Against Free Radicals and MDR Isolates

    Snehalata Khuntia, Jyotirmayee Lenka, Manaswini Dash, Bhaskar Chandra Sahoo, Basudeba Kar, Suprava Sahoo

    pp. 615–625 · DOI: 10.1177/09731296231174958 · Published 2023

    Background: Curcuma caesia Roxb. (Black turmeric) is a perennial medicinal herb belonging to the Zingiberaceae family that is endangered in Southeast Asia. It is treasured for its high-quality essential oil with tremendo…

13. Article

    Inhibition of Tumor Glycolysis by Umbelliferone and its Binding to Glycolytic Proteins

    Kangbo Peng, Yingxiao Wang, Xia Lei, Yang Wang, Yanfang Yang, Song-Tao Wu

    pp. 626–637 · DOI: 10.1177/09731296231170256 · Published 2023

    Background and Objectives: Both primary and secondary cancers require the involvement of glycolytic pathways. Cancer cell proliferation leads to the upregulation of glycolysis, which results in increased glucose consumpt…

14. Article

    Study on Chemical Constituents of the Enriched Extracts of Erigeron multiradiatus and Anti-thrombotic Effect on Zebrafish

    Li Li, Wenfang Jin, Yue Wang, Li Yang, Zhi-Feng Zhang

    pp. 638–650 · DOI: 10.1177/09731296231184536 · Published 2023

    Background: Erigeron multiradiatus (Lindl.) Benth. has been used for years to treat various diseases in Traditional Tibetan Medicine (TTM). Our previous studies have shown that E. multiradiatus extract has important phar…

15. Article

    Protective Effects of Safflor Yellow A Against H2O2-induced Oxidative Stress Injury in PC12 Cells via Nrf2/HO-1 Pathway

    Hui Chen, Sichun Gu, Yi You, Anjie Xie, Yiying Lu, Changde Wang

    pp. 651–659 · DOI: 10.1177/09731296231170255 · Published 2023

    Background: Safflor yellow (SY) is a water-capacitive component of dried flowers, mainly from safflor in the safflower family, which contains a large amount of bruthin A, or Safflor yellow A (SYA) for short. Studies have…

16. Article

    Preliminary Screening of in vitro Kaempferia galanga Oil for Anti-Proliferative Activities Against HeLa and MCF-7 Cell

    Rajashree Panigrahi, Reena Parida

    pp. 660–666 · DOI: 10.1177/09731296231172544 · Published 2023

    Background: Kaempferia galanga, commonly known as aromatic ginger, is a potential herb with high medicinal value and is used to treat many diseases like diabetes and asthma. Cancer is a group of diseases characterized by…

17. Article

    Schisandrin A Suppresses Inflammation in DSS-induced IBD Mice and H2O2-induced MODE-K Cells through Wnt/β-Catenin Signaling

    Hong Xu, Xi Chen, Xinlei Li, Deqiang Dou, Zhili Xu

    pp. 667–677 · DOI: 10.1177/09731296231172552 · Published 2023

    Background: Schisandrin A (SchA) has multiple pharmacological features, and inflammatory bowel disease (IBD) represents a common digestive system disease mainly characterized by inflammation. Objectives: To assess the an…

18. Article

    Salvianolate Ameliorates Renal Damage Induced by C-BSA in Membranous Nephropathy Rats Through Inhibiting Hypercoagulable State and Alleviating Podocyte Injury

    Wenjun Chen, Jinchuan Tan, Suzhi Chen, Fengwen Yang, Huiming Yan, Huiling Duo, Huijie Zhou

    pp. 678–688 · DOI: 10.1177/09731296231170082 · Published 2023

    Background: Membranous nephropathy (MN), one of the primary pathogenic forms of adult nephrotic syndromes, frequently coexists with hypercoagulability and hyperviscosity. MN is prone to thrombosis, embolism, and other co…

19. Article

    Obtaining Acid-sensitive Prosaikogenin F by Enzymatic Hydrolysis of Saikosaponin A

    Yeting Zhu, Jiangsong Peng, Yaqin Zhao, Mengru Wu, Suping Chen, Jiali Shao, Xubo Wang, Guohua Xia, Yuping Shen

    pp. 689–699 · DOI: 10.1177/09731296231169577 · Published 2023

    Background: Prosaikogenin F (PSF) has stronger anti-cancer bioactivity than saikosaponin A (SSA), however, it was hardly isolated due to its trace amount in the raw material of Radix Bupleuri (RB). In addition, the activ…

20. Article

    Reversal Effect of Saikosaponin A and Saikosaponin B on Doxorubicin-resistant Breast Cancer Cells and its Mechanism

    Dan Wang, Duochun Ji, Danni Wu, Like Wang, Chunyan Yu, Chun Li, Xiaodong Gai

    pp. 700–708 · DOI: 10.1177/09731296231171217 · Published 2023

    Background: One of the key factors limiting the effectiveness of chemotherapy treatment for malignancies is multidrug resistance (MDR). The MDR phenotype is related to P-glycoprotein (P-gp) expression and function. The m…

21. Article

    Optimization of Extraction Process and Anti-Hemorrhoidal Activity of Blumea lacera (Burm.f.) DC. Leaves in Croton Oil-induced Hemorrhoid Model

    Tarkeshwar Dubey, Kancharla Bhanukiran, Satyendra K. Prasad, Siva Hemalatha

    pp. 709–719 · DOI: 10.1177/09731296231170936 · Published 2023

    Background and Objectives: Blumea lacera (Burm.f.) DC. (Family—Asteraceae) is widely used for treating hemorrhoids by several ethnomedicinal practitioners and tribes in India. Thus, the main objective of the present inve…

22. Article

    Caffeic Acid Markedly Induced Apoptosis of Human Multiple Myeloma Cells through the Caspase-dependent Pathway

    Likun Sun, Jing Ren, Xiumei Feng, Shengli Li, Yongjing Wang, Yang Jiang, Chengyun Zheng

    pp. 720–726 · DOI: 10.1177/09731296231170926 · Published 2023

    Background: Caffeic acid (CA) or 3,4-dihydroxycinnamic acid is a polyphenolic compound primarily found in coffee, herbs, berries, and other fruits. Its antioxidant, anti-inflammatory, and immunomodulatory effects on mult…

23. Article

    β-asarone Protects p-tau from Okadaic Acid in PC12 Cells by Activating PP2A and Involving Akt/mTOR/Beclin-1 Pathway

    Liping Huang, Xiaoqin Zhong, Yuanhang Xu, Minzhen Deng, Zhongliu Zhou

    pp. 727–735 · DOI: 10.1177/09731296231168743 · Published 2023

    Background: The aggregation of tau hyperphosphorylation (p-tau) into neurofibrillary tangles (NFT) is a hallmark in the histopathology of Alzheimer’s disease (AD). Our previous experiments found that β-asarone could prev…

24. Article

    Inhibitory Potential of Apium graveolens L. Extract on Inflammation in Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice

    Anisha Lyngdoh, Taranga Jyoti Baruah, Rajeshwar Nath Sharan, Lakhon Kma

    pp. 736–750 · DOI: 10.1177/09731296231170931 · Published 2023

    Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer, with a recurrence rate of 80–90% and a high mortality rate. It is an inflammation-related cancer where cytokines production plays a majo…

25. Article

    Network Pharmacology and Experimental Analyses on Astragalus membranaceus (Huangqi) Effects on Endotoxin-induced Uveitis Model in Rats

    Jing Lu, Yujie Wu, Yijing Yang, Jing Zhou, Bo Huang, Chengfeng Xie, Qinghua Peng, Xiaohuan Zhang

    pp. 751–762 · DOI: 10.1177/09731296231169576 · Published 2023

    Objectives: This study is aimed at identifying critical therapeutic targets of Astragalus membranaceus (Huangqi (HQ)) and investigating the effects and mechanisms of HQ treating uveitis. The potential drug targets of HQ …

26. Article

    Identification of Ziziphi Spinosae Semen from its Adulterants Based on RAPD

    Fu-Long Xia, Hong-Wei Cao, Li-Xia Gao, Qing-Kong Qing-Kong, Mei-Li Mei-Li, Chuan-jie Wang, Yang-Niu Yang-Niu

    pp. 763–771 · DOI: 10.1177/09731296231171216 · Published 2023

    Background: Ziziphi spinosae semen (ZSS), dry mature seeds of Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F. Chow., are widely used in the treatment of insomnia, fright palpitations, and profuse dreaming in medica…

27. Article

    Effects of Selenium on Growth and Biochemical Characters of Tissue Culture Seedlings of Sophora tonkinensis

    Lin-xuan Li, Zhu Qiao, Jin-yuan Cai, Ying Liang, Yang Lin, Gui-li Wei, Xiao-li Hou, Jian-hua Miao, Kun-hua Wei

    pp. 772–781 · DOI: 10.1177/09731296231169614 · Published 2023

    Background: Selenium (Se) plays a key role in controlling several processes in plant development, such as root growth and regulation of enzyme activity. However, research on the effects of Se in Sophora tonkinensis, a me…

28. Article

    Cornus officinalis Sieb. et Zucc. Alleviates Mitochondrial Abnormalities and Heart Failure through AMPK

    Liu-Dan Chen, Ke-Fang Chen, Ke Chen, Liang Ai, Meng-Ru Kang, Wei-Min Yi, Jian-Jun Li

    pp. 782–790 · DOI: 10.1177/09731296231172540 · Published 2023

    Background: Traditional Chinese medicine (TCM) has clear advantages in stabilizing patients with heart failure (HF) and improving cardiac functions. Aims: This study aimed to investigate the role of Cornus officinalis Si…