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    Article

    Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis

    Yongjie Lu1, Lushi Cheng1, Lu Ren1, Dongqiu Chen1, Shumin Guan1, Siyang Zhu1, Xian Xu1, Bing Zhang2★, Minghui Tang1, Chijian Zhang1, Yong Ai1, Lanyue Zhang3, Tinggang He1★ Corresponding author

    1. 1School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, CHINA.
    2. 2Guangdong He Ji Biotech Co., Ltd., Guangzhou, CHINA.
    3. 3Hua An Tang Biotech Group Co., Ltd., Guangzhou, CHINA.

    CORRESPONDENCE

    Bing Zhang

    Guangdong He Ji Biotech Co., Ltd., Guangzhou, CHINA.

    zhanglanyue@gdut.edu.cn

    Received: 29-01-2023; Accepted: 02-06-2023.

    Volume 20, Issue 1 · pp. 72–80 · PUBLISHED 2024 · DOI: 10.1177/09731296231198931

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses antiinflammatory, anti-bacterial, and anti-cancer effects. Objectives: Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with imiquimod-induced psoriasis. Materials and Methods: After treatment with GLs, their effectiveness was assessed using parameters, such as Psoriasis Area and Severity Index (PASI) score, histopathology, inflammatory cytokines, and psoriasis-associated proteins. Results: The results demonstrated that GLs could significantly improve psoriatic symptoms, downregulate mast cell infiltration, and significantly reduce the PASI score of psoriatic mice. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) results showed that GLs significantly decreased IL-23 and STAT3 mRNA expression. The results of immunohistochemistry and the enzyme-linked immunosorbent assay indicated that GLs decreased the expression of tumor necrosis factor-alpha (TNF-α), IL-17, and IL-22. Conclusion: GLs can alleviate psoriasis by inhibiting the expression of keratinocyte-activating proteins. These results suggest that GLs have great potential for the clinical treatment of psoriasis.

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      Lu, Y., Cheng, L., Ren, L., Chen, D., Guan, S., Zhu, S., Xu, X., Zhang, B., Tang, M., Zhang, C., Ai, Y., Zhang, L., & He, T. (2024). Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis. Pharmacognosy Magazine, 20(1), 72–80. https://doi.org/10.1177/09731296231198931