Volume 20, Issue 1

2024 · pp. 7–356 · 29 articles

Volume: 20
Issue: 1
Published: 2024
Pages: 7–356
Articles: 29
Sections: 1
ISSN: ISSN: Print - 0973-1296, Online - 0976-4062
Journal: Pharmacogn. Mag.

Original Research Article

In this issue

Original Research Article

Article
Chemical Composition of Essential Oils of Medicinal Plants Grown in the Thrace Region in Türkiye, Hypericum perforatum L.
Fevziye Deniz Güler, Nurullah Ozdemir
pp. 101–106 · DOI: 10.1177/09731296231201210 · Published 2024
Background: There are many active substances in the composition of the Hypericum perforatum L. plant that have different and complex structures and show different pharmacological effects. It was accepted as a medicinal p…
Article
Investigating the Anti-inflammatory Effects of Rutin in Carbon Tetrachloride-induced Hepatotoxicity: Role of TLR4/MyD88/NFκB Signaling Pathway Modulation
Qianyu He, Hu Hao, Keke Zhao
pp. 107–115 · DOI: 10.1177/09731296231203454 · Published 2024
Objectives: Rutin protects and stabilizes hepatocytes and is used to treat hepatitis, liver cirrhosis, and other diseases. However, there is little evidence to suggest that Rutin is associated with CCl4-induced hepatotox…
Article
Systematic Characterization of the Chemical Components and Absorbed Prototypes in Sanqi Xueshangning Capsules Using UPLC-Q-TOF-MS with SCIEX OS Software
Hongling Zhao, Na Li, Xiaoyan Cui, Yongzhou Yu, Zi Liu, Jianhui Chen, Yuxuan Tian, Chunying Zhao, Hui Xiong
pp. 116–126 · DOI: 10.1177/09731296231204152 · Published 2024
Background: Sanqi Xueshangning Capsules (SXC) is a famous Chinese patent medicine with a good curative effect on various gynecological pain diseases in China. However, its chemical composition and potential active ingred…
Article
Network Pharmacology to Explore the Mechanism of Prunella vulgaris L. Against Prolactinoma
Jun-Hua Meng, Ping Ni, Yu-Ling Cao, Yu Zhang, Xiong Wang, Hong Zhang, Yong-Gang Chen
pp. 127–136 · DOI: 10.1177/09731296231189329 · Published 2024
Objectives: Prolactinoma is a common intracranial tumor with a high incidence and serious harm to human health. At present, there is only one therapeutic drug in China, bromocriptine, and the Chinese herb Prunella vulgar…
Article
Phytochemical Profiling, Antioxidant, and Antifungal Activities of Ethyl Acetate and Chloroformic Extracts from Three Mentha Species
Nouha Bouali, Hafedh Hajlaoui, Soumaya Arraouadi, Mohd Saeed, Munazzah Tasleem, Snoussi Mejdi, Adel Kadri
pp. 137–145 · DOI: 10.1177/09731296231202104 · Published 2024
Background: Phytopathogenic fungi remain the main infectious agents in plants, causing severe damage to the environment and human health. Thus, to reduce the usage of synthetically derived fungicides and perform agricult…
Article
In silico Rationalization for Leads from Oldenlandia umbellata L. to Inhibit Multiple Molecular Targets Regulating Osteoporosis
Sivasakthi Paramasivam, Senthamil Selvan Perumal
pp. 146–158 · DOI: 10.1177/09731296231196189 · Published 2024
Background: Osteoporosis is a chronic metabolic bone disease caused due to the dysregulation in the functioning of osteoblast and osteoclast cells leading to increased bone resorption predominantly in postmenopausal wome…
Article
Bee Pollen and Doxorubicin by Synergistic Effects Inhibit the
Molecular Approach Jinwen Li
pp. 159–178 · DOI: 10.1177/09731296231203809 · Published 2024
Objectives: This study investigated the effects of BP and doxorubicin (DOX) on 4T1 tumor cells in a mouse model. Materials and Methods: After inducing breast tumors, 70 4T1-tumor-bearing BALB/c mice were divided into sev…
Article
Phytochemical Profiling and Assessment of Habbe Musaffe Khoon Against Cervical Cancer
Nidhi Sharma, Prerna Raina, Ghazalla Mulla, Anand Shindikar, Prajakta Patil, Supriya Bhalerao, Ruchika Kaul-Ghanekar
pp. 179–188 · DOI: 10.1177/09731296231204132 · Published 2024
Background: In India, cancer of the cervix is the second most common cancer in women. Nowadays, various traditional herbal formulations can be used as adjuncts during conventional cancer therapies due to their anticancer…
Article
Research Advancements in Pharmacological Activities and Mechanisms of Matrine
Xiaohui Chen, Panpan Liu, Yanni Mao, Guiqin Wang
pp. 189–205 · DOI: 10.1177/09731296231203458 · Published 2024
Matrine possesses a broad spectrum of pharmacological activities as one of the primary components of Chinese herbal medicine Sophora flavescens extract, along with fewer side effects and low toxicity. Matrine possesses a…
Article
Mutagenic, Anti-mutagenic, and Cytotoxic Activities of Methanol, Hexane, and Ethyl Acetate Extracts of Zingiber zerumbet (L.) Smith
Farah Syahibah Mohd Hariri, Asmah Hamid, Nor Fadilah Rajab
pp. 206–217 · DOI: 10.1177/09731296231207226 · Published 2024
Background: Zingiber zerumbet (L.) Smith (lempoyang) has a traditional application in the treatment of indigestion, worm infestation, loss of appetite, and postpartum conditions. Objectives: Extracts of Z. zerumbet (meth…
Article
Phytochemical Composition, Bioavailability and Pharmacokinetics of Scorzonera undulata Methanolic Extracts: Antioxidant, Anticancer, and Apoptotic Effects on MCF7 Cells
Imen Bédoui, Hmed Ben Nasr, Kamilia Ksouda, Wajdi Ayadi, Nour Louati, Mohamed Chamkha, Sirine Choura, Jalel Gargouri, Serria Hammami, Hanen Affes, Walid S. Hamadou, Nourhene Zammel, Subuhi Sherwani, Khaled Zeghal, Riadh Badraoui
pp. 218–229 · DOI: 10.1177/09731296231207231 · Published 2024
Background: Finding new effective substances to develop drugs against cancer or to prevent it remains a big challenge facing scientists and clinicians. Objectives: In such an issue, we tested the anti-tumoral effect of S…
Article
A Novel Tumor Glycolysis Inhibitor: 4-Methylumbelliferone
Zi-Yao Li, Qin Yang, Xiao-Ge Cheng, Yan-Li Zhou, Xiang-Ling Piao, Li Qiu, Bo-Jun Zhou, Song-Tao Wu
pp. 230–244 · DOI: 10.1177/09731296231206300 · Published 2024
Background and Objectives: 4-Methylumbelliferone (4-MU) is a coumarin compound that can be extracted from the medicinal plant with anti-cancer properties, Smilax china L. In recent years, studies have revealed its potent…
Article
Metabolic and Pharmacokinetic Investigation
Antibiotic-treated Rats Di Cao, Zhengjiao Wang, Xiuting Shen, Xiaojun Song, Zhongxiang Zhao
pp. 245–256 · DOI: 10.1177/09731296231198608 · Published 2024
Background: Ilexsaponin A1 (IA1) is a bioactive triterpene saponin derived from natural medicinal plants. IA1 exhibits antiinflammatory and proangiogenic activities and improves intestinal barrier function. It has been r…
Article
GRg1 Ameliorates Insulin Resistance Through Activation of the PI3K/AKT/GSK-3β Pathway in HepG2 Cells
Xunjun Shen, Yamei Jin, Yuting Chen, Huadi Yang
pp. 257–267 · DOI: 10.1177/09731296231198284 · Published 2024
Background: Insulin resistance (IR) is a pathological state closely associated with various diseases, with hepatic insulin resistance playing a pivotal role. Insulin resistance can be improved by Ginsenoside Rg1 (GRg1), …
Article
Plumbagin Attenuates Ovalbumin-induced Allergic Asthma in Mice through Inhibition of Inflammatory Response
Dong Yiming, Abdullah R Alzahrani, Abubucker Peer Mohideen
pp. 268–279 · DOI: 10.1177/09731296231184537 · Published 2024
Background: Asthma is a prominent non-communicable inflammatory disease that affects both children and the elderly. Younger people are more prone to asthma, and most prescribed anti-asthmatic medicines relieve symptoms b…
Article
Modulations by L-Carvone and Thymoquinone to Exert Protection on Bone Marrow Cells Against Benzene-induced Toxicities Through Anti-inflammatory Pathways in SD Rats
Enjun Kong, Yan Xu, Hong Jin, Tahani Awad Alahmadi, Samer Hasan Hussein Al Ali
pp. 280–290 · DOI: 10.1177/09731296231201510 · Published 2024
Background: Adverse effects of benzene (BZ) exposure toxicities were documented by many researchers worldwide. BZ exposure causes many hematological abnormalities that might be treated with naturally occurring phytocompo…
Article
Shexiang Tongxin Dropping Pretreated Mesenchymal Stem Cells-derived Exosomes Attenuate Cardiac Ischemia/Reperfusion Injury by Modulating miR-182-5p and miR-199a-3p-mediated Inflammatory Responses
Ling-Yan Li, Ling-Fang Zhou, Jia Shi, Zong-Jun Liu, Jun-Qing Gao
pp. 291–302 · DOI: 10.1177/09731296231207232 · Published 2024
Background: Previous research has highlighted the regulatory role of miR-182-5p in targeting TLR4 during the pathogenesis of allergic rhinitis. In a different context, TLR4 has been identified as a crucial factor in the …
Article
Anti-obesity Effects of Triphala at Biochemical and Molecular Level in High-Fat Diet-induced Obese Rats
Supriya Sudhakar Bhalerao, Asavari Anirudha Joshi, Suresh Khadke, Arulmozhi Sathiyanarayan
pp. 30–42 · DOI: 10.1177/09731296231198316 · Published 2024
Background: The prevalence of obesity is rising worldwide. Due to the side effects associated with modern drugs, there is a need for an alternative treatment for obesity management. Triphala (TP), a polyherbal formulatio…
Article
Screening of Chenopodium hybridum L. for Anti-ovarian Cancer Compounds Using UPLC-Q-Exactive MS and Partial Least Squares Analysis
Shuli Yang, Duanduan Cheng, Xueqin Feng, Ruixin Lin
pp. 303–315 · DOI: 10.1177/09731296231198930 · Published 2024
Background: Extracts of Chenopodium hybridum L. leaves and stems exerted a significant anti-proliferative effect on human A2780 ovarian cancer cells, but C. hybridum active components have not been reported. Materials an…
Article
Gastrodin Ameliorates Knee Joint Inflammation and Pain in Osteoarthritis Rats and Prevents Chondrocyte Injury by Regulating PI3K/Akt/FoxO1 Pathway
Jiang-Long Shi, Li-Yun Liu, Yu-Ting Dong, Tao Shen
pp. 316–327 · DOI: 10.1177/09731296231203860 · Published 2024
Background: Several studies have demonstrated the anti-inflammatory properties of gastrodin. However, its specific role and mechanism in the context of osteoarthritis (OA) remain unclear. Objectives: The objective of thi…
Article
Functional Properties of the Water Extract from Eriocheir sinensis (Chinese mitten crab) Via Evaluation of Protective Effects on Reflux Esophagitis Model
Hyeon Hwa Nam, Jun Ho Song, Jun Lee, Byeong Cheol Moon, Sumin Noh, Li Nan, Byung Kil Choo, Joong-Sun Kim
pp. 328–335 · DOI: 10.1177/09731296231189324 · Published 2024
Objectives: In the study, we investigated the effects of an Eriocheir sinensis water extract on a reflux esophagitis-induced rat model. Background: The crab has been used as a traditional medicine and food source in many…
Article
Prunetin Triggers ROS-mediated Apoptosis through the Suppression of MAPKs/STAT-3/NF-κB-p65 Signaling Pathway in Human Osteosarcoma Cells
Meng Gao, Ya Wang, Weibo Liu, Zelong Song, Xiangyu Wang, Xuesong Zhang
pp. 336–346 · DOI: 10.1177/09731296231188784 · Published 2024
Background: Osteosarcoma (OS) is a highly metastatic primary bone malignancy, and the treatment options remain inadequate. Hence, exploring innovative natural medications is required. Prunetin (PRU) is an isoflavone that…
Article
Anti-convulsant Effects of Scutellarein in a PTZ Kindling Model in Mice
Jun Duan, Jiao Wang, Qian Zhao, Dean Wu, Yang Liu
pp. 347–356 · DOI: 10.1177/09731296231203790 · Published 2024
Background: Epilepsy is a chronic neurological condition with various underlying mechanisms. It is known to affect a multitude of people across the globe, regardless of age and gender. Seizures associated with epilepsy i…
Article
Rhapontigenin Improves Non-alcoholic Fatty Liver Disease by Inducing Lipophagy Through
the ACOX, mTOR/ULK1 Pathways Ying-Xiao Wang, Xin-Ge Ke, Chen Wang, Kang-Bo Peng, He-Zhen Wu, Yan-Fang Yang
pp. 43–56 · DOI: 10.1177/09731296231197299 · Published 2024
Background: Non-alcoholic fatty liver disease (NAFLD) is severely affecting the quality of people’s life. Rhapontigenin (RA) is a stilbene compound isolated from Rhubarb L., which has been reported to have an effect on c…
Article
Quality Control and Multi-targeted Therapeutic Approach of Nyctanthes arbor-tristris for Management of Hepatic Disease and Associated Complications
Sapna Salar, Pankaj Sharma, Gaurav Gaurav
pp. 57–71 · DOI: 10.1177/09731296231189619 · Published 2024
Background: Medicinal plants standardization is more concerning for its regulatory aspects based on safety, quality, and efficacy. Nyctanthes arbor-tristris is an Indian-origin medicinal plant that is used for numerous a…
Article
Mechanism of Ziyuglycoside II-mediated Ferroptosis-related Proteins on the Proliferation and Metastasis of Human Lung Adenocarcinoma Cell Lines
Jian-hui Zhang, Li-jun Xie, Han-lu Wang, Hui Chen, Xiao-rong Meng, Xing Lin, Xin-fu Lin, Li-sheng Liao, Ting Chen, Jie-Wei Luo, Lu-yu Hong, Xin Chen
pp. 7–15 · DOI: 10.1177/09731296231169588 · Published 2024
Background: Ferroptosis is a novel type of regulated cell death and targeting ferroptosis may be a potential treatment strategy for lung cancer. Ziyuglycoside II (ZYG II) has a significant inhibitory effect on the growth…
Article
Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis
Yongjie Lu, Lushi Cheng, Lu Ren, Dongqiu Chen, Shumin Guan, Siyang Zhu, Xian Xu, Bing Zhang, Minghui Tang, Chijian Zhang, Yong Ai, Lanyue Zhang, Tinggang He
pp. 72–80 · DOI: 10.1177/09731296231198931 · Published 2024
Background: Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses antiinflammatory, anti-bacterial, and anti-cancer effects. Objectives: Herein, the therapeutic effects and mech…
Article
Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
Gang Wang
pp. 81–88 · DOI: 10.1177/09731296231190686 · Published 2024
Background: Modern strategies to alleviate the harmful effects of organophosphate pesticide diazinon (DN) abnormalities were focused mainly on using natural compounds or their derivatives. DN is an organophosphate compou…
Article
Xiegan-Liangxue-Jiedu Decoction Alleviated Psoriasis and Depressionlike Behavior in a Mouse Model: Role of the AC–cAMP–PKA–CREB Signaling Pathway
Jia-chen Shi, Ping Wu, Yong-mei Li, Xiao-rui Li
pp. 89–100 · DOI: 10.1177/09731296231190691 · Published 2024
Objectives: Psoriasis vulgaris is an immune-mediated inflammatory skin disease that is associated with depression. In this study, we investigated the effect of Xiegan–Liangxue–Jiedu (XGLXJD) decoction, a traditional Chin…