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    Article

    Efficacy and Safety of Traditional Chinese Medicine Combined with Dexrazoxane on Cardiotoxicity-induced Anthracyclines-based Chemotherapy: A Meta-Analysis

    Siyan Mo1★, Zhengyin Zhou3, Jinlong Ning3, Ning Li3, Meiqing Nie1, Yun Zhou4, Fanjian Zeng1, Haiyan Li3★ Corresponding author

    1. 1Department of Clinical Pharmacy, The Traditional Chinese Medicine Hospital of Hezhou, Hezhou, Guangxi Province, CHINA.
    2. 2Department of Pharmacy, The People’s Hospital of Hezhou, Hezhou, Guangxi Province, CHINA.
    3. 3Department of Traditional Chinese Medicine, The Traditional Chinese Medicine Hospital of Hezhou, Hezhou, Guangxi Province, CHINA.
    4. 4School of Pharmacy, Guilin Medical University, Guilin, Guangxi Province, China.

    CORRESPONDENCE

    Siyan Mo

    Department of Clinical Pharmacy, The Traditional Chinese Medicine Hospital of Hezhou, Hezhou, Guangxi Province, CHINA.

    d-v-wade2007@163.com

    Received: 02-03-2023; Accepted: 06-09-2023.

    Volume 20, Issue 2 · pp. 412–422 · PUBLISHED 2024 · DOI: 10.1177/09731296231208603

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Traditional Chinese Medicine (TCM) has been used in the treatment of anthracycline (ANTs)-induced cardiotoxicity. This meta-analysis aims to evaluate systematically the efficacy and safety of TCM combined with dexrazoxane (DRZ) on cardiotoxicity caused by ANTs. Materials and Methods: Retrieval of the China National Knowledge Infrastructure (CNKI), WAN FANG DATA, Chinese Biomedical Database (CBM), Cochrane Library, and PubMed was conducted through various methods. The meta-analysis was registered on PROSPERO (Registration ID: CRD42023435324). A randomized controlled trial (RCT) of TCM in combination with DRZ to avert cardiotoxicity caused by ANTs was compiled. The efficacy and safety of TCM Combined with DRZ, the cardiotoxicity induced by ANTs was synthesized and discussed, along with the outcomes of cardiac troponin T (cTnT), cardiac troponin I (cTnI), brain natriuretic peptide (BNP), creatine kinase isoenzymes (CK-MB), creatine kinase (CK), left ventricular ejection fraction (LVEF), electrocardiogram (ECG) abnormalities, and the incidence of adverse reactions. RevMan 5.3 was used for meta-analysis. Results: A total of 10 RCTs with 746 patients were included. The pooled results showed that TCM combined with DRZ treatment decreased significantly the incidence of ECG abnormalities (RR = 0.47, 95% CI [0.32,0.70], p = 0.0001), the level of cTnT (MD = −7.16, 95% CI [−8.31, −6.02], p<0.001), CK (MD = −14.94, 95% CI [−22.91, −6.97], p<0.001), cTnI (MD = −0.10, 95% CI [−0.14, −0.06], p<0.001), BNP (MD = −33.66, 95% CI [−36.95, −30.37], p<0.001), CK-MB (MD = −5.93, 95% CI [−8.16, −3.70], p<0.001). However, there was no significant change in LVEF in the experimental group compared with the control group (MD = 4.81, 95% CI [−02.99, 12.21], p = 0.23). Moreover, adverse events have no significant difference between the two groups as well (RR = 0.60, 95% CI [0.31, 1.15], p = 0.13). Conclusion: This meta-analysis revealed TCM combined with DRZ appears to be able to improve the efficacy of cardiotoxicity caused by ANTs, but the included studies were of poor quality, and high-quality RCTs would be preferred for future studies.

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      Mo, S., Zhou, Z., Ning, J., Li, N., Nie, M., Zhou, Y., Zeng, F., & Li, H. (2024). Efficacy and Safety of Traditional Chinese Medicine Combined with Dexrazoxane on Cardiotoxicity-induced Anthracyclines-based Chemotherapy: A Meta-Analysis. Pharmacognosy Magazine, 20(2), 412–422. https://doi.org/10.1177/09731296231208603