Volume 20, Issue 2

A Review on Exploring the Phytochemical and Pharmacological Significance of Indigofera astragalina

V. Rajani, S. Umadevi, C. Naga Raju

pp. 363–371 · DOI: 10.1177/09731296231215911 · Published 2024

Indigofera astragalina, a versatile medicinal plant, has gained significant attention because of its rich phytochemical composition and diverse therapeutic properties. I. astragalina contains sterols, phenolics, alkaloid…

Effect of Cynara scolymus L. on Cardiometabolic Outcomes: An Updated Meta-analysis of Randomized Controlled Trials and Meta-regression

Wiraphol Phimarn, Bunleu Sungthong, Kittisak Wichiyo

pp. 372–388 · DOI: 10.1177/09731296231217557 · Published 2024

Background: Artichoke (Cynara scolymus L.) has the potential to treat diabetes, dyslipidemia, hypertension, and obesity. However, the evidence from previous studies is not consistent. Objectives: This meta-analysis evalu…

Methanol Extract of Petasites japonicus Promotes Apoptosis via the MAPK and ROS-dependent Signaling Pathways

Na-Ri Choi, Woo-Gyun Choi, Min Ji Kwon, Joon Park, Yun Tai Kim, Min Jae Lee, Jae-Woo Park, Joo Han Woo, Byung Joo Kim

pp. 389–401 · DOI: 10.1177/09731296231216167 · Published 2024

Background: Petasites japonicus (PJ), also known as Butterbur, has a rich history as a traditional healing remedy across numerous countries. Objectives: This study was designed to evaluate the potential anti-cancer prope…

Valproic Acid Treatment Improves Organ Function, Survival Rate, and Lipid Peroxidation in Fatally Scalded Rats

Rui Liu, Yu-Tuo Fu, Feng-Qi Jiang, Yi-Jie Ye, Shu-Ming Wang

pp. 402–411 · DOI: 10.1177/09731296231211466 · Published 2024

Background: After hypovolemic shock caused by severe burns, lipid peroxidation is an important factor in tissue edema and multiorgan dysfunction syndrome (MODS). Many studies have shown that valproic acid (VPA) inhibits …

Efficacy and Safety of Traditional Chinese Medicine Combined with Dexrazoxane on Cardiotoxicity-induced Anthracyclines-based Chemotherapy: A Meta-Analysis

Siyan Mo, Zhengyin Zhou, Jinlong Ning, Ning Li, Meiqing Nie, Yun Zhou, Fanjian Zeng, Haiyan Li

pp. 412–422 · DOI: 10.1177/09731296231208603 · Published 2024

Background: Traditional Chinese Medicine (TCM) has been used in the treatment of anthracycline (ANTs)-induced cardiotoxicity. This meta-analysis aims to evaluate systematically the efficacy and safety of TCM combined wit…

Mechanism of Cistanche deserticola Ma in the Treatment of Myocardial Ischemia-Reperfusion (I/R) Injury Based on Network Pharmacology and in vitro Experiments

Yuan-Jia Yue, Yu Li, Huimin Wang, Zhao Ji, Xing Rong, Lin Jiang

pp. 423–429 · DOI: 10.1177/09731296231214855 · Published 2024

Objectives: To investigate the mechanism of Cistanche deserticola Ma (CDA) in the treatment of myocardial ischemiareperfusion (I/R) injury by network pharmacology and cell experiments. Materials and Methods: The main act…

Lactobacillus plantarum Enhanced the Cardioprotective Efficacy of Arctiin in Isoproterenol Cardiac Injury in BALB/c Mice

Kun Jiang, Yanjun Jia, Tahani Awad Alahmadi, Samer Hasan Hussein-Al-Ali, Yajing Wei

pp. 430–443 · DOI: 10.1177/09731296231211453 · Published 2024

Background: Isoproterenol is a drug used for the treatment of bradycardia that has many side effects due to its non-selective β-adrenoceptor agonist properties. Aim: In this study, we evaluated an in vivo experimental mo…

Auraptene Alleviates Paclitaxel-induced Neuropathy in Mice

Zihong Cong, Jun Wang, Mahmoud Hashemzaei, Suiyun Xu

pp. 444–450 · DOI: 10.1177/09731296231198573 · Published 2024

Background: Paclitaxel administration causes peripheral neuropathy. Auraptene is a natural bioactive monoterpene with anti-inflammatory and anti-neuropathic effects that is widely used. Objectives: We aimed to study aura…

Bioinformatics Analyzes the Mechanisms of Codonopsis Radix in Treating Ovarian Cancer

Zhenhui Chen, Yan Zhou, Yun Shen, Yanrong Ye

pp. 451–461 · DOI: 10.1177/09731296231204151 · Published 2024

Background: Codonopsis Radix (CR), a renowned traditional Chinese medicine (TCM) formula, has been widely applied for its immunomodulatory, antitumor, antioxidant, neuroprotective, and antiviral effects. However, the mul…

Determination of Four Chemical Components in Qishen Yiqi Dripping Pills by UPLC-MS/MS Method

Qin Lili, Zhang Honglian, Wang Yanxia, Liang Yingying, Li Qiang, Xie Xuerong

pp. 462–469 · DOI: 10.1177/09731296231203449 · Published 2024

Background: In this study, the ultrahigh performance liquid chromatography mass spectrometry/mass spectrometry (UPLC-MS/MS) method was established to test the contents of protocatechuic acid (C₇H₆O₄), salvianolic acid B …

Bee Pollen Stimulated BMP2 and RANK Signaling Pathway in Osteoprogenitors and Improved Bone Mineralization in Rat Model of Femur Fracture

Xiaowan Zeng, Yajing Lin, Chaonan Wang

pp. 470–484 · DOI: 10.1177/09731296231198286 · Published 2024

Objectives: Bee pollen (BP) contains isoflavonoids and minerals that can be effective in bone repair, stimulation of osteoprogenitors, differentiation of osteoblasts, and inhibition of osteoclasts. For this purpose, in t…

Relaxation Effect of Schisandrol A on Isolated Thoracic Aorta and its Mechanism in Rats Xudong Qiu1, Yang Dong2, Bihan Wang2, Shuo Yang2, Jinghui Sun2,

He Li, Jianguang Chen, Xingxu Du, Chun Mei Wang

pp. 485–493 · DOI: 10.1177/09731296231203855 · Published 2024

Background: Schisandra chinensis (S. chinensis) is a drug commonly used in the clinical treatment of cardiovascular diseases in Traditional Chinese Medicine. However, the specific components and mechanisms of its action …

Morin Inhibits Cell Proliferation and Induces Caspase-mediated Apoptotic Cell Death in Glioma C6 Cell Line

Shan Zhu, Huisheng Yuan, Tahani Awad Alahmadi, Hesham S. Almoallim, ChangLi Wang

pp. 494–504 · DOI: 10.1177/09731296231216828 · Published 2024

Background: Glioma is a recurrent form of primary malignant cancer that occurs in the brain and central nervous system. The adults are the major victims of gliomas, and the men are mostly affected. At present, gliomas ar…

Ginsenoside CK Induces the Mitochondrial Apoptosis in Glioma Cells through the Activation of the p53-Bax-Caspase Pathway

Yang Bai, Yuanhao Liu, Lihao Lin, Xinze Liu, Xilin Wan, Xinmin Wu

pp. 505–515 · DOI: 10.1177/09731296231203457 · Published 2024

Background: Gliomas are harmful to human health; they are the most common primary intracranial tumor. Ginsenoside CK (GS-CK) is converted from the diol ginsenoside. This study aimed to explore the effects of GS-CK on gli…

RIBE from Multiple Irradiation and the Protective Effects of Astragalus Polysaccharides on Methylation and Cancer-associated Proteins in BMSCs

Liying Zhang, Ting Zhou, Yiming Zhang, Lei Wang, Yangyang Li, Gucheng Zhou, Heng Zhou, Fan Niu, Zhiwei Liu, Zhiming Miao, Yongqi Liu

pp. 516–527 · DOI: 10.1177/09731296231204762 · Published 2024

Background: Ionizing radiation can induce bystander effects (RIBE), and Astragalus polysaccharides (APS) have a protective effect against RIBE. It has been proved that RIBE occurred and APS played the inhibitory effects …

Study on the Fingerprints of Acanthopanax trifoliatus Fractions with Varying Polarities and the Relationship Between Anti-inflammatory and Antioxidant Activity Using Multivariate Analysis

Zijiu Liang, Xiaohong Huang, Lin Jiang, Qinghua Lin, Renyi Zhang, Changyuan Lin, Xinghong Lai, Mengjiao Xie, Haiyan Chen, Qing Chen, Fangchan Li

pp. 528–540 · DOI: 10.1177/09731296231201032 · Published 2024

Objectives: To evaluate the Spectrum-Effect relationships between the High-Performance Liquid Chromatography (HPLC) Fingerprints of fractions with different polarities and the anti-inflammatory and antioxidant effects of…

Subacute Oral Toxicity Studies of Pankajakasthuri Orthoherb Tablets Formulated for Managing Pain and Inflammation of Joints

Hareendran Nair J, Kasthuri Nair A, Sithara MS, Shan Sasidharan

pp. 541–552 · DOI: 10.1177/09731296231215578 · Published 2024

Objectives: The objective of this investigation was to assess the subacute oral toxicity of the Pankajakasthuri Orthoherb Tablets, a polyherbal formulation used to manage pain and inflammation due to various pathological…

The Anti-tumor Function of Shikonin by Targeting EGFR/AKT/mTOR Signaling in Human Osteosarcoma Cells

Rui-Dan Zhu, Jia-Jia Zhang, Xiao-Bin Yao, Zhang-Jiao Wang, Zhi-Ling Du, Qing-Xia Xu

pp. 553–562 · DOI: 10.1177/09731296231215938 · Published 2024

Background: Shikonin, a purified naphthoquinone separated from a Traditional Chinese medicinal herb Lithospermum erythrorhixon, which exhibits anticancer properties. Objectives: To clarify the molecular mechanisms of the…

Baicalin Promotes Apoptosis of Human Medullary Breast Cancer via the ERK/p38 MAPK Pathway

Xianyong Li, Qianqian Tang, Wenwei Li, Dongzai Zhan, Xiangyang Fang, Shengchao Huang, Xiaorong Shui, Jianwen Li

pp. 563–571 · DOI: 10.1177/09731296231215134 · Published 2024

Objectives: The present study aims to examine the effects of baicalin on the human medullary breast carcinoma (MBC) cell line Bcap-37 and to determine whether baicalin regulates Bcap-37 cell apoptosis through the ERK/p38…

Oxyepiberberine from the Active Site of Coptidis Rhizoma Inhibits Lung Adenocarcinoma by Regulating SRC-related Pathways in vivo

Ying Zhang, Yongqi Xue, Jing Zeng, Hezhen Wu, Yanfang Yang

pp. 572–584 · DOI: 10.1177/09731296231213147 · Published 2024

Background: Huanglian (HL), also known as Coptis chinensis Franch., was initially documented in “Sheng Nong’s Herbal Classic” as a high-quality product used to cure ailments such as fever, indigestion, bloating, nausea, …

Experimental Studies on the Effects of Glycitinregulated TGF-β Signaling Pathway on the Proliferation, Osteogenic, and Lipogenic Differentiation of BMSCs

Jiabo Zhu, Liyan Zhang, Xin Sun, Jiaming Liang, Hanlian Li

pp. 585–594 · DOI: 10.1177/09731296231212048 · Published 2024

Background: Glycitin, generated from the seeds of the legume soybean, has an essential function in antioxidant, obesity inhibition, and wound healing promotion. Furthermore, recent research has shown that it has anti-inf…

Mechanism of Schisandra chinensis in Treatment of Insomnia by Sleep–Wake Cycle Based on Network Pharmacology

Ke Liang, Tie Qiao, Ning Sun, Ning Jiang, Fangxiao Li, Haoxuan Jiang, Yutong Jiang

pp. 595–605 · DOI: 10.1177/09731296231216171 · Published 2024

Background: Schisandra chinensis (SC) is the dried fruit of SC of Magnoliaceae, which has been used to treat many diseases, such as asthma, cough, insomnia, spontaneous sweating, and so on, for more than 2000 years. Lign…

Calycosin Protects against Focal Cerebral Ischemia/Reperfusion Injury via Inhibiting the HMGB1/TLR4/NF-κB Signaling Pathway

Yong Wang, Shifeng Wang, Peng Zhang, Shengjun Xiao, Huizhong Shi, Zihan Chen

pp. 606–615 · DOI: 10.1177/09731296231215158 · Published 2024

Background: The rate of disability and mortality associated with cerebral ischemia/reperfusion injury (CIRI) is high due to limited treatment options, making it a major challenge to clinical management. Calycosin is a bi…

Analysis of Shared Mechanisms and Chinese Herbal Medicines Between Osteoporosis and Type 2 Diabetes

Huawen Yang, Fanwei Luo, Zhongyu Xiong

pp. · DOI: 10.1177/09731296231215568 · Published

Chikusetsusaponin IVa Protects against H9N2 Avian Influenza Virus Infection by Inhibiting Inflammation and TLR4/NF-κB Signaling Pathways in vitro and in vivo

Qi Dai, Xin Zheng, Song-Tao Wu, Peng-Tao You, Xiao Huang, Yan-Wen Liu, Yun Wu, Xiu-Qiao Zhang

pp. 632–645 · DOI: 10.1177/09731296231216165 · Published 2024

Background: The prevalence of Hemagglutinin 9 Neuraminidase 2 (H9N2) avian influenza virus (AIV) in poultry in Asia has raised serious concerns about its zoonotic transmission and the potential for a pandemic, underscori…

Gentianella turkestanorum (Gand.) Holub, a Chinese Herbal Medicine that can Alleviate T2DM in Db/db Mice, and its Active Mechanism of Action

Ying Wei, Jiaxin Sun, Liya Su, Tunhai Xu

pp. 646–655 · DOI: 10.1177/09731296231215577 · Published 2024

Background: The increasing prevalence of type 2 diabetes mellitus (T2DM) on a global scale has created a pressing demand for novel treatments. Gentianella turkestanorum (Gand.) Holub, a traditional Chinese herbal medicin…

Anwulignan Alleviates the Acute Liver Injury Induced by Acetaminophen in Mice

Zhao Chenghe, Wang Yao, Jing Shu, Lin Huijiao, Li He, Chen Jianguang, Xia Wei

pp. 656–665 · DOI: 10.1177/09731296231220116 · Published 2024

Background: Drug-induced liver injury (DILI) is extremely common in clinical practice and needs to be focused. Anwulignan is a unique lignan monomer of Schisandra Sphenanthera Fructus and is used as the main active ingre…

Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Myocardial Injury in Type 2 Diabetic Rats by Regulating Autophagy

Ying Liu, Leilei Ma, Wenxuan Xu, Xiaojin La, Biwei Zhang, Jianmei Cui, Chunyu Tian, Hong Chang

pp. 666–675 · DOI: 10.1177/09731296231220433 · Published 2024

Background: Diabetes mellitus (DM) is a persistent metabolic condition resulting from insufficient insulin or insulin resistance, which gives rise to diverse complications endangering human well-being. Ramulus Mori (Sang…

Genistein Alleviates Dextran Sulfate Sodiuminduced Ulcerative Colitis in Mice by Regulating Th17/Treg Cell Balance: Implication for the G Protein-coupled Estrogen Receptor

Baolian Shu, Youxing Wu, Xiaoyang Wang, Jianlan Hu, Danxia Zhang, Xianghao Gong, Saiqi He, Yangzhi Xie, Xuan Chen, Ruohu Gui

pp. 676–685 · DOI: 10.1177/09731296231217599 · Published 2024

Objectives: This study aimed to evaluate the therapeutic effects and mechanism of genistein on dextran sulfate sodiuminduced mouse model of ulcerative colitis (UC). Materials and Methods: A DSS-induced mouse model for UC…

Biological Control of Ustilaginoidea virens Using Chelerythrine Suspension

Qinghui Wei, Weifeng Song, Xinmin Li, Min Zhao

pp. 624–631 · DOI: 10.1177/09731296231217551 · Published 2026

Background: High efficiency, low toxicity, and environmentally safe pesticides are increasingly being sought and developed to ensure sustainable development and high-yield agricultural production. Chelerythrine has stron…