Gentianella turkestanorum (Gand.) Holub, a Chinese Herbal Medicine that can Alleviate T2DM in Db/db Mice, and its Active Mechanism of Action
Ying Wei1★, Jiaxin Sun1, Liya Su1, Tunhai Xu2★ Corresponding author
- 1Clinical Medical Research Center, The Affiliated Hospital/Autonomous Region Key Laboratory of Medical Cell Biology, Inner Mongolia Medical University, Hohhot, Inner Mongolia, CHINA.
- 2School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, Chaoyang, China.
CORRESPONDENCE
Ying Wei
Clinical Medical Research Center, The Affiliated Hospital/Autonomous Region Key Laboratory of Medical Cell Biology, Inner Mongolia Medical University, Hohhot, Inner Mongolia, CHINA.
Received: 08-09-2023; Accepted: 27-10-2023.
Volume 20, Issue 2 · pp. 646–655 · PUBLISHED 2024 · DOI: 10.1177/09731296231215577
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ABSTRACT
Background: The increasing prevalence of type 2 diabetes mellitus (T2DM) on a global scale has created a pressing demand for novel treatments. Gentianella turkestanorum (Gand.) Holub, a traditional Chinese herbal medicine, has been found to possess hypoglycemic effects. However, the mechanism of its action remains unclear. Objectives: This study was to investigate the impact and mechanism of G. turkestanorum’s water extract (WEG) in reducing insulin resistance (IR) in T2DM. Materials and Methods: Db/db mice were administered WEG for 8 weeks, during which their body weight, blood glucose (BG), oral glucose tolerance test, islet tolerance test, fasting insulin, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were monitored. Additionally, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in db/db mice were measured using enzyme-linked immunosorbent assay (ELISA). The study also evaluated the impact of WEG on liver injury through hematoxylin-eosin staining. The expression levels of key proteins and genes in both insulin signaling and inflammation-related pathways were detected using western blotting and real-time quantitative polymerase chain reaction. Results: WEG has the potential to regulate glycolipid metabolism, reduce inflammation, and alleviate IR. The mechanism of action may involve promoting the insulin signaling pathway and inhibiting inflammation. Conclusion: Gentianella turkestanorum could be a viable treatment option for T2DM and IR.
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Wei, Y., Sun, J., Su, L., & Xu, T. (2024). Gentianella turkestanorum (Gand.) Holub, a Chinese Herbal Medicine that can Alleviate T2DM in Db/db Mice, and its Active Mechanism of Action. Pharmacognosy Magazine, 20(2), 646–655. https://doi.org/10.1177/09731296231215577