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    Review

    Targeting Intrinsic and Extrinsic Pathways of Ferroptosis: A Novel Anticancer Strategy of Curcumin

    Wei Hao1, Yuan Gao1, Bangwei Cao1★★ Corresponding author

    1. 1Cancer Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    CORRESPONDENCE

    Bangwei Cao

    Cancer Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

    caobangwei@ccmu.edu.cn

    Received: 05-02-2024; Accepted: 08-04-2024.

    Volume 20, Issue 4 · pp. 1061–1070 · PUBLISHED 2024 · DOI: 10.1177/09731296241251957

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The turmeric rhizome yields a medicinal compound called curcumin. Curcumin’s anticancer methods mostly involve blocking cell invasion and proliferation, controlling gene expression, preventing angiogenesis, triggering apoptosis, and inducing ferroptosis. A brand-new nonapoptotic kind of planned cell death is called ferroptosis. Ferroptosis can be initiated through two major pathways: the extrinsic or transporter-dependent pathway, and the intrinsic or enzyme-regulated pathway. It is unknown, therefore, how curcumin and its derivatives prevent cancer by controlling ferroptosis. Purpose: Through this review, we concentrate on the possible anticancer mechanisms of curcumin by means of its effect on ferroptosis; the regulation of iron metabolism, the synthesis of reactive oxygen species, and the targeting of antioxidant pathways represent a few of these processes. Methodology: Retrieve English literature of curcumin and its derivatives in the treatment of tumor by ferroptosis from databases such as Web of Science, etc. Conclusion: This review provides a rationale for the clinical use of curcumin and its derivatives as anticancer agents.

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      Hao, W., Gao, Y., & Cao, B. (2024). Targeting Intrinsic and Extrinsic Pathways of Ferroptosis: A Novel Anticancer Strategy of Curcumin. Pharmacognosy Magazine, 20(4), 1061–1070. https://doi.org/10.1177/09731296241251957