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    Article

    Nerolidol Alleviates Oxidative Stress and Inflammation in Diabetic Retinopathy Mediated by High Glucose through Ameliorating Nrf2/HO-1 Pathway

    Changhong Li1, Buchao Shi2, Dong Li3, Hui Li2★★ Corresponding author

    1. 1Department of General Medical, The People’s Hospital of Hengshui (Harrison International Peace Hospital), Hengshui, Hebei Province, China
    2. 2Department of Neurology, The No. 5 People’s Hospital of Hengshui, Hebei Province, China
    3. 3Department of Ultrasound, The No. 5 People’s Hospital of Hengshui, Hebei Province, China

    CORRESPONDENCE

    Hui Li

    Department of Neurology, The People’s Hospital of Hengshui (Harrison International Peace Hospital), Hengshui, Hebei Province 053000, China.

    lihui295929@sina.com

    Received: 09-09-2023; Accepted: 06-02-2024.

    Volume 20, Issue 4 · pp. 1313–1321 · PUBLISHED 2024 · DOI: 10.1177/09731296241247922

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Diabetic retinopathy (DR) is the foremost microvascular problem that causes drastic visual impairment in diabetes patients. Hyperglycemia-triggered reaction cascade of inflammation and oxidative stress constitute the DR pathogenesis. The existing treatment options are not completely satisfactory. Materials and Methods: We investigated the cell viability by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, inflammatory mediators, lactate dehydrogenase (LDH), superoxide dismutase, glutathione, and malonaldehyde (MDA) levels by ELISA and qRT-PCR assay, protein expression of Nrf2 and heme oxygenase-1 (HO-1) by western blotting assay were analyzed. Results: According to our research, nerolidol (NRD) increases the proliferation and antioxidant activity of human retinal endothelial cells (HRECs) by inducing Nrf2/HO-1 signaling, while attenuating MDA, an oxidative stress marker, LDH, and inflammatory mediators. These outcomes suggest that a substantial reaction of inflammation and oxidative stress injury happened in DR, which might be correlated to the instigation of the signaling Nrf2/HO-1. Conclusion: NRD effectively suppresses oxidative stress and inflammation in HG-induced HRECs. The primary mechanism of NRD on DR may be linked to the activation of the Nrf2/HO-1 pathway and may give a useful medicine for DR treatment.

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      Li, C., Shi, B., Li, D., & Li, H. (2024). Nerolidol Alleviates Oxidative Stress and Inflammation in Diabetic Retinopathy Mediated by High Glucose through Ameliorating Nrf2/HO-1 Pathway. Pharmacognosy Magazine, 20(4), 1313–1321. https://doi.org/10.1177/09731296241247922