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    Review

    Isolation and Pharmacochemistry of α-Mangostin as a Chemotherapeutic Agent

    Mohammed Abu Sayeed3, Min Gab Kim1★★ Corresponding author

    1. 1College of Pharmacy and Research Institute of Pharmaceutical Science, PMBBRC, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, REPUBLIC OF KOREA.
    2. 2Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, THAILAND.
    3. 3Department of Pharmacy, International Islamic University Chittagong, Chattogram, Chittagong, Bangladesh Corresponding author: Min Gab Kim, College of Pharmacy and Research Institute of Pharmaceutical Science, PMBBRC, Gyeongsang National University, Jinju-si, Gyeongsangnam-do 52828, Republic of Korea. E-mail: mgk1284@gnu.ac.kr.

    CORRESPONDENCE

    Min Gab Kim

    College of Pharmacy and Research Institute of Pharmaceutical Science, PMBBRC, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, REPUBLIC OF KOREA.

    mgk1284@gnu.ac.kr

    Received: 30-03-2024; Accepted: 13-04-2024.

    Volume 21, Issue 1 · pp. 27–43 · PUBLISHED 2025 · DOI: 10.1177/09731296241262567

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    A naturally occurring xanthone, mangostanin (1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9- one), was isolated from Garcinia mangostana L. It demonstrates a range of pharmacological effects, such as antibacterial, antifungal, antiviral, anti-inflammatory, and anticancer activity. The α-mangostin’s isoprenyl and benzopyrone skeleton side chains are crucial to its antibacterial activity. In this review, we review the current approach for the isolation of α-mangostin from plant sources and the recent report on its biological activity. The structure–activity relationship is discussed to demonstrate the pharmacophore of α-mangostin responsible for its anti-infective properties, including antibacterial, antifungal, and antiviral activities. The potential approaches for developing α-mangostin for the treatment of infectious diseases are proposed as future perspectives.

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      Sayeed, M. A., & Kim, M. G. (2025). Isolation and Pharmacochemistry of α-Mangostin as a Chemotherapeutic Agent. Pharmacognosy Magazine, 21(1), 27–43. https://doi.org/10.1177/09731296241262567