Volume 21, Issue 1

2025 · pp. 7–314 · 29 articles

Volume: 21
Issue: 1
Published: 2025
Pages: 7–314
Articles: 29
Sections: 2
ISSN: ISSN: Print - 0973-1296, Online - 0976-4062
Journal: Pharmacogn. Mag.

Original Research Article Review Article

In this issue

Original Research Article

Article
Hepatoprotective Role of Persea americana (Lauraceae) on Eimeria papillata-induced Infection in Mice
Rewaida Abdel-Gaber, Esam M. Al-Shaebi, Tahani Al-Otaibi, Esam S. Al-Malki, Nawal Al-Hoshani, Saleh Al Quraishy
pp. 107–115 · DOI: 10.1177/09731296241264060 · Published 2025
Background: Eimeria papillata is a parasitic protozoan that causes intestinal coccidiosis in mice. Due to the rise of drugresistant strains, medicinal plants are now employed to treat parasite diseases. Objectives: This …
Article
Research on the Improvement of Endothelial Cell Function and Trophoblast Apoptosis in Rats with Preeclampsia by Tanshinone IIA
Hui Dong, Jie Song, Yanju Jia, Hongyan Cui, Xu Chen
pp. 116–123 · DOI: 10.1177/09731296241277301 · Published 2025
Background: Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of damage to another organ system, often the kidneys. Recent studies suggest that endothelial dysfunction and trophoblas…
Article
Study on Action and Mechanism of Potentilla discolor Bunge using Patch-Clamp to Explore the Effect of the Main Components of Potentilla discolor Bunge on Myocardial Cell Membranes
Yanxin Dang, Wenjie Zhao, Xiaohan Li, Yongchao Chen, Jie Liu, Lin Li, Minzhen Xie, Zhouxiu Chen, Siqi Gu, Qi Wang, Guijun Liu
pp. 124–132 · DOI: 10.1177/09731296241280347 · Published 2025
Background: Potentilla discolor Bunge (PDB) is a plant of the Rosaceae family. A wide range of pharmacological activities, such as antibacterial, hypoglycemic, and others, can be achieved through its chemical components,…
Article
Resatovir Combined with Glycyrrhizic Acid Ameliorates Osteoarthritis and Enhances Autophagy in Chondrocytes
Qijie Mei, Wenfei Xu, Qi Hu, Jinrong Guo, Chao Zeng, Chunyu Ming, Chongming Li, Changshen Yuan, Kan Duan
pp. 133–141 · DOI: 10.1177/09731296241283126 · Published 2025
Background: Osteoarthritis (OA) is a chronic disease worldwide. With resatovir usually used as an inhibitor, resatovir and glycyrrhizic acid have several pharmacological activities. Objectives: We intend to explore the m…
Article
Edible Vitalmelon Fruit Extract Promotes Lipolysis of MDI-stimulated 3T3-L1 Adipocytes through the Stimulation of Glycerol Release and β-oxidation
You Jeong Jin, Su Jin Lee, Ji Eun Kim, Yu Jeong Roh, Hee Jin Song, Ayun Seol, Tae Ryeol Kim, Kyeong Seon Min, Eun Seo Park, Gi Ho Park, Hye Mi Kang, Nam Jun Kang, Ki Won Lee, Young-Whan Choi, Dae Youn Hwang
pp. 142–151 · DOI: 10.1177/09731296241266394 · Published 2025
Background and Purpose: The anti-obesity effects of vitalmelon extracts have been well verified in only adipogenesis and lipogenesis of adipocytes and high-fat diet-induced obesity mice except lipolysis. Therefore, we we…
Article
Study on the Mechanism of Guizhi Fuling Decoction in Treating Hyperlipidemia Based on Network Pharmacology and Experimental Methods
Mi Zhang, Yuntian Zhang, Hongyun Wang, Chunlei Fan
pp. 152–160 · DOI: 10.1177/09731296241281441 · Published 2025
Background: Hyperlipidemia, caused by abnormal lipid metabolism, has become a significant health concern, especially in younger populations. While statins are commonly used for treatment, they often cause severe side eff…
Article
Identification of Astragalus Polysaccharide as a Neuroprotective Agent via Activating Klotho-mediated Nrf2 Pathway
Kuo Liu, Nannan Ding, Mengying Han, Shuping Shen, Lin Li, Fang Bian, Li Chen, Ji Zhang, Lailiang Qu, Dan Yang
pp. 161–169 · DOI: 10.1177/09731296241279103 · Published 2025
Background: Neurodegenerative diseases (NDs) have become a significant public health problem, and oxidative stress (OS) serves as a pivotal factor in the pathological progression of NDs. Pharmacological research indicate…
Article
Monotropein Reduces Retinal Inflammation, Oxidative Stress, and Dyslipidemia in Streptozotocin-induced Diabetic Retinopathy in Rats
Yuxi Jia
pp. 170–180 · DOI: 10.1177/09731296241281421 · Published 2025
Background: Diabetic retinopathy (DR) is a major cause of visual problems and ultimately results in vision loss. Nearly 25% of diabetic patients have suffered from DR. Objectives: The present research has been designed t…
Article
Anti-arthritic and Anti-inflammatory Activity of Different Types of Milk in Complete Freund’s Adjuvant-induced Arthritis in Male Adult Rats
Doha M. Al-Nouri, Ghalia Shamlan, Latifah Y. Al-Faifi, Wahidah H. Al-Qahtani, Ghedeir M. Alshammari, Islam A. El Redh, Shaista Arzoo
pp. 181–191 · DOI: 10.1177/09731296241262555 · Published 2025
Background: Rheumatoid arthritis (RA) is a chronic, immune-inflammatory disease that could be managed by an attenuation in dietary habits. With the increase in research that links the effect of nutrition linked to RA. Ob…
Article
Picroside Ⅱ Inhibits Glycolysis and Migration in HepG2 Cells
Xia Lei, Si-Cheng Yang, Kang-Bo Peng, Meng-Fan Wang, He-Zhen Wu, Yan-Fang Yang
pp. 192–206 · DOI: 10.1177/09731296231220980 · Published 2025
Objectives: The objective of this study was to investigate the impacts and mechanisms of Picroside II on hepatocellular carcinoma (HCC). Materials and Methods: The GeneCards database was mined for HCC-related targets. Th…
Article
Inhibitory Effect of Cayratia albifolia C. L. Li Extract on LPS-induced Inflammation of RAW264.7 Cells by Regulating the Nrf2/ HO-1 Axis
Yi Tan, Liang Cao, Dan Zhou, Biao Qin, Yanbin Zhang, Jianxin Liu, Kai He, Bin Li, Zaiqi Zhang
pp. 207–217 · DOI: 10.1177/09731296241266095 · Published 2025
Background: Cayratia albifolia C. L. Li (Jiao Mei Gu (JMG)) has potential therapeutic effects in inflammatory diseases. Objectives: The primary goal of the research was to focus on the antioxidant and anti-inflammatory q…
Article
Wogonin Alleviates Streptozotocin-stimulated Diabetic Nephropathy through its Antidiabetic, Antidyslipidemic, and Antioxidative Effects in Rats
Dong Li, Hui Li, Buchao Shi, Changhong Li
pp. 218–228 · DOI: 10.1177/09731296241274880 · Published 2025
Background: Diabetes mellitus (DM) is a prolonged endocrine syndrome recognized by defective metabolism of biomolecules on account of flaws in insulin resistance. Diabetic nephropathy (DN) is a central microvascular comp…
Article
Investigation of Cytotoxicity and Lipid-lowering Effects of Rivea hypocrateriformis Desr. Leaf Extracts on HepG2 Cells: An in vitro Study
Helen Sheeba Devadhasan Aspathi Bai, Gandhimathi Rethnaswamy
pp. 229–242 · DOI: 10.1177/09731296241263660 · Published 2025
Background and Purpose: Chronic diseases, such as cardiovascular disease as well as type 2 diabetes, are associated with hyperlipidemia, characterized by high blood lipid levels. HepG2 cells, a human liver cancer cell li…
Article
Aucubin Induces Apoptotic Cell Death Through Caspase-dependent Pathways in Human Osteosarcoma MG-63 Cells
Mengfan Cui, Pengyu Chen
pp. 243–255 · DOI: 10.1177/09731296241277314 · Published 2025
Background: Osteosarcomas (OSs) are predominantly generated by mesenchymal cells, which commonly develop in the distal and upper regions of the bones. OS has high mortality rates and treatment failures, mostly due to the…
Article
Protective Role of Anthraquinone Purpurin Against Cardiotoxicity Induced by Isoproterenol in Adult Wistar Rats
Xuecai Wang, Yaguo Huang, Xiaojuan Sun, Bing Zhao
pp. 256–268 · DOI: 10.1177/09731296241281446 · Published 2025
Background: Purpurin are naturally occurring anthraquinones derived from the roots of Rubia species. Purpurin is a redcolored bioactive compound commonly used as a food colorant. In ancient times, Rubia species plants we…
Article
Attenuation of L-NAME-induced Hypertension in Rats with Elettaria cardamomum–Low-dose Amlodipine Combination: A Possible Synergism of Covasodilatory Effect
Abdulaziz K. Al Mouslem, Dimah I. Almuayli, Sara M. Aldaej, Zainab A. Alhaddad, Fatimah J. Alhamad, Promise M. Emeka, Enas S. Gad
pp. 269–281 · DOI: 10.1177/09731296241278035 · Published 2025
Background: Hypertension is a prevalent chronic disorder that affects approximately 1.28 billion adults worldwide. In the use of amlodipine, though it is a cost-effective antihypertensive agent, it causes side effect tha…
Article
Ameliorative Potency of Iridoid Glucoside Compound Catalpol on Inhibiting NF-κB-mediated Inflammation in Allergic Rhinitis-induced Mice
Haiting Wang, Jing Wang
pp. 282–292 · DOI: 10.1177/09731296241281429 · Published 2025
Background: Over time, the prevalence of allergic rhinitis (AR) has surged due to various risk factors, notably attributed to global urbanization, rendering heightened levels of pollutants, including traffic-related emis…
Article
The Extract of Camellia japonica L. Protects against Mice Cerebral Ischemia/Reperfusion Injury via Promoting the H2S-BKCa Pathway
Weizhuo Lu, Zenghong Jiang, Jiyue Wen
pp. 293–304 · DOI: 10.1177/09731296241265738 · Published 2025
Background and Objectives: The effect and mechanism of the extract of Camellia japonica L. (ECJ) on brain injury following cerebral ischemia/reperfusion (I/R) were demonstrated in the present study. Materials and Methods…
Article
Green Synthesis of Chitosan-coated Tin Dioxide Nanoparticles Using Moringa oleifera Flower Extract Against Breast Cancer via the Caspase-dependent Apoptotic Pathway
Ahmad Alsulimani, Saleh M. Abdullah, Ahmed Ali Jerah, Ali M. Hendi, Abdullah Farasani
pp. 305–314 · DOI: 10.1177/09731296241276588 · Published 2025
Background and Purpose: In the present work, chitosan is furnished with tin dioxide (CsSnO2) nanoparticles (NPs) synthesized using the green route using Moringa oleifera (M. oleifera) flower extract. Materials and Method…
Article
Exploring the Potential Antidiabetic Effects of Alkannin (A Naphthoquinone Compound): in vivo and in silico Studies
Mohd Saeed, Ambreen Shoaib, Lubna Azmi, Asma Al-Shammary, Md Jahoor Alam, Yazeed Albulaihed, Vishal M Balaramnavar, Chandrakant Bonde, Mohd Adnan Kausar, Abdelmuhsin Abdelgadir, Saad Saeed Alqathani, Irfan Ahmad Ansari
pp. 44–54 · DOI: 10.1177/09731296241274877 · Published 2025
Background: It is estimated that the plant has been utilized in India’s traditional medical system for close to 2,500 years. Alkanin is a key active component in Boraginaceae medicinal plant roots. Many scientists are in…
Article
Determination of Four Compositions of Lonicerae japonicae flos Based on UPLC–MS/MS Method
Xie Ran, Liu Feng, Fang Hongying, Xu Yuguo, Zhang Honglian
pp. 55–59 · DOI: 10.1177/09731296241265167 · Published 2025
Background: Lonicerae japonicae flos, a representative kind of Traditional Chinese Medicine (TCM) for clearing heat and detoxifying, is known as Jinyinhua in China. The determination of multiple components’ content, espe…
Article
Study on the Mechanism of Phellinus linteus Extract Slowing Down Breast Cancer by Regulating Cdc42/N-WASP Signaling Pathway
Qishan Sun, Xiaodong Zhan, Feng Jiang
pp. 60–66 · DOI: 10.1177/09731296241281445 · Published 2025
Background: Cell division control protein 42 homolog (Cdc42)/neuronal Wiskott–Aldrich Syndrome Protein (N-WASP) is involved in a variety of tumors; however, its regulatory mechanism in breast cancer is unclear. Objective…
Article
Evaluation of Immunomodulatory Activity of a Polyherbal Formulation (Phytocee™) Using ex vivo and in vitro Models Naveen Kumar M.1
Sasi Kumar Murugan, Bharathi Bethapudi, Deepak Mundkinajeddu
pp. 67–73 · DOI: 10.1177/09731296241281434 · Published 2025
Background: The immune system plays a crucial role in protecting the host by regulating biological activities in multiple organs and circulatory fluids. The phytoextracts are evident to modulate a series of biological ac…
Article
Study on Cantharidin Reversing the Drug-resistance of Non-small Cell Lung Cancer to DDP by Regulating the Expression of PD-L1
Xing Jin, Chunhui Ma, Xiaojing Tan, Jian Qian, Yongbing Chen, Dongfeng Wang
pp. 74–80 · DOI: 10.1177/09731296241262832 · Published 2025
Background and Purpose: Cantharidin can or cannot reverse the drug resistance of non-small cell lung cancer to cisplatin (DDP) by reducing the expression of programmed cell death ligand 1 (PD-L1). Materials and Methods: …
Article
Pseudomonas aeruginosa-Mannose Sensitive Hemagglutinin-based Treatment Strategy for Liver Cancer
Lan Li, Lina Yin, Jia Shi, Li Zheng, Liu Min, Xiaoling Wu
pp. 81–88 · DOI: 10.1177/09731296241282390 · Published 2025
Background: Although it does not represent a threat to healthy humans, Pseudomonas aeruginosa is a type of aerobic, gramnegative bacteria that can cause catastrophic infections in patients with immune system abnormalitie…
Article
Inhibitory Effects of Dioscoreae Rhizoma and Polygalae Radix Mixture Combined with Sorafenib in Hepatoma Xenografts Model
Mi-Rae Shin, Jeong Won Choi, Seong-Soo Roh
pp. 89–98 · DOI: 10.1177/09731296241262566 · Published 2025
Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies and a leading cause of cancerrelated mortality and morbidity worldwide. Objectives: This study evaluated the enhanced efficacy of a combin…
Article
Investigation into the Effect of Emodin-8-O-β- D-glucoside on Sleep Improvement in a Mouse Experimental Model
Qi Li, Yong Zhou, Hai-Feng Yang, Guang-Hong Yu, Xiao-Hui Chi
pp. 99–106 · DOI: 10.1177/09731296241264616 · Published 2025
Background: Poor sleep quality and even insomnia are global problems, especially after the COVID-19 pandemic, and bioactive substances in natural herbal medicines may improve subjective sleep for people with insomnia. Ho…

Review Article

Review
Isolation and Pharmacochemistry of α-Mangostin as a Chemotherapeutic Agent
Mohammed Abu Sayeed, Min Gab Kim
pp. 27–43 · DOI: 10.1177/09731296241262567 · Published 2025
A naturally occurring xanthone, mangostanin (1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9- one), was isolated from Garcinia mangostana L. It demonstrates a range of pharmacological effects, such…
Review
The Effect of Psoralea corylifolia (Babchi) on Neuronal Apoptosis Induced by Palmitate in PC12 Cells and its Role in Alzheimer’s Disease: A Review
Sachin Ranjan, Nidhi Singh Kushwaha, Shalini Trivedi, Neha Tiwari, Salman Khan
pp. 7–26 · DOI: 10.1177/09731296241243132 · Published 2025
Psoralea corylifolia (PC) seed extract (PCE) has been extensively utilized as an herbal drug due to its favorable effects on human health. It’s extracts and active components have demonstrated a variety of biological act…